Employing 11-Ketotestosterone as a Target Analyte for Adrenosterone (11OXO) Administration in Doping Controls

Autor: Thomas Piper, Gregor Fußhöller, Mario Thevis

Publikováno v: Metabolites, Vol 14, Iss 3, p 141 (2024)

Adrenosterone (Androst-4-ene-3,11,17-trione, 11OXO) is forbidden in sports according to the Prohibited List of the World Anti-Doping Agency. The administration of 11OXO may be detected by monitoring the urinary concentrations of its main human metabo

Externí odkaz: https://doaj.org/article/3a75e2d51526408d980b6b75f24196fd

Identification of Trenbolone Metabolites Using Hydrogen Isotope Ratio Mass Spectrometry and Liquid Chromatography/High Accuracy/High Resolution Mass Spectrometry for Doping Control Analysis

Autor: Marlen Putz, Thomas Piper, Mario Thevis

Publikováno v: Frontiers in Chemistry, Vol 8 (2020)

Trenbolone is a synthetic anabolic-androgenic steroid, which has been misused for performance enhancement in sports. The detection of trenbolone doping in routine sports drug testing programs is complex as methods utilizing gas chromatography/mass sp

Externí odkaz: https://doaj.org/article/9bd898f4a6d84ef5a88f95e3548fa5ed

AICAr to SAICAr ratio can serve as additional marker of AICAr use

Autor: Tim Sobolevsky, Thomas Piper, Brian Ahrens, Mario Thevis

Publikováno v: Drug testing and analysisREFERENCES. 14(11-12)

AICAr (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside, commonly referred to as AICAR) is an adenosine monophosphate-activated protein kinase agonist previously investigated for its therapeutic potential which has been shown to improve exercise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702aa018e0f6d74d0486150cc7ed8b71
https://pubmed.ncbi.nlm.nih.gov/36342242

Carbon isotope ratios of endogenous steroids found in human serum—method development, validation, and reference population-derived thresholds

Autor: Eberhard Nieschlag, Lia Bally, Hans Geyer, Mario Thevis, Thomas Piper

Publikováno v: Analytical and Bioanalytical Chemistry
Piper, Thomas; Geyer, Hans; Nieschlag, Eberhard; Bally, Lia; Thevis, Mario (2021). Carbon isotope ratios of endogenous steroids found in human serum-method development, validation, and reference population-derived thresholds. Analytical and bioanalytical chemistry, 413(22), pp. 5655-5667. Springer 10.1007/s00216-021-03439-9

In order to detect the misuse of testosterone (T), urinary steroid concentrations and concentration ratios are quantified and monitored in a longitudinal manner to enable the identification of samples exhibiting atypical test results. These suspiciou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d3bebf6f24d714d46e838a3a044fad
https://doi.org/10.1007/s00216-021-03439-9

Investigations on the in vivo metabolism of 5α‐androst‐2‐en‐17‐one

Autor: Thomas Piper, Gregor Fusshöller, Wilhelm Schänzer, Mario Thevis

Publikováno v: Rapid Communications in Mass Spectrometry. 36

The anabolic steroid 5α-androst-2-en-17-one (2EN) is sold as a prohormone and has been investigated regarding its potential as a steroidal aromatase inhibitor. The administration of 2EN was detected in a doping control sample in 2015, and investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7098f6a50e2a6b00af0ee4dfab03d8d8
https://doi.org/10.1002/rcm.9343