Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Thomas Pinter"'
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998
https://doi.org/10.1021/acs.jmedchem.2c00998
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::531f44b082fb5f00fe6c2f82d97a48bc
https://pubmed.ncbi.nlm.nih.gov/36126059
https://pubmed.ncbi.nlm.nih.gov/36126059
BACKGROUND A growing number of college students are experiencing personal circumstances or encountering situations that feel overwhelming and negatively affect their academic studies and other aspects of life on campus. To meet this growing demand fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6668e6f9c01ca99b63065ee6a7ca23f
https://doi.org/10.2196/preprints.10032
https://doi.org/10.2196/preprints.10032
Publikováno v:
The Journal of Organic Chemistry. 78:4642-4648
Tetrazoles are potent anion binders. We report here a new family of tetrazole-pyrrole-amide hosts that arise when a tetrazole is incorporated as a new binding element alongside the well-known amidopyrrole anion-binding scaffold. In addition to report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7b79a200d7049ac01cd6a0bf5e2403f
https://doi.org/10.1021/jo400372c
https://doi.org/10.1021/jo400372c
Publikováno v:
The Journal of Organic Chemistry. 76:3733-3741
Tetrazoles and acyl sulfonamides are functional groups that are common in medicinal chemistry but virtually unexplored as recognition elements in supramolecular chemistry. We report here on the anion binding properties of these highly acidic N-H func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ad4d747ad99503c482e456a06b95d3
https://doi.org/10.1021/jo200031u
https://doi.org/10.1021/jo200031u
Autor:
Thomas Pinter, Russell E. Bishop, Patrick J. Mott, Mary Vu, Fraser Hof, Joel Moktar, Aaron H. McKie, M. Adil Khan
Publikováno v:
Biochemistry. 49:9046-9057
The Escherichia coli outer membrane phospholipid:lipid A palmitoyltransferase PagP selects palmitate chains using its β-barrel-interior hydrocarbon ruler and interrogates phospholipid donors by gating them laterally through an aperture known as the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c8bb02edc332f7bf5978cc6f05e353
https://doi.org/10.1021/bi1011496
https://doi.org/10.1021/bi1011496
Publikováno v:
Organic Letters. 11:1717-1720
Concise syntheses of 2,5-disubstituted-3-hydroxytetrahydrofurans have been developed that provide access to each configurational isomer of this scaffold from a single aldol adduct. Application of these methods to the rapid preparation of (6S,7S,9S,10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c8f96d72ec195c0650078825924da0
https://doi.org/10.1021/ol802711s
https://doi.org/10.1021/ol802711s
Autor:
Fraser Hof, Thomas Pinter
Publikováno v:
Springer Series on Chemical Sensors and Biosensors ISBN: 9783642323287
Proteins are highly evolved, sophisticated machines which function together to maintain homeostasis in their hosts. While merely a collection of amino acids covalently bonded in a specific sequence, their wide variety of functions is truly remarkable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::098ea44c29983a5d111ea15c5b2cd605
https://doi.org/10.1007/5346_2012_15
https://doi.org/10.1007/5346_2012_15
Publikováno v:
ChemInform. 40
Concise syntheses of 2,5-disubstituted-3-hydroxytetrahydrofurans have been developed that provide access to each configurational isomer of this scaffold from a single aldol adduct. Application of these methods to the rapid preparation of (6S,7S,9S,10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d973f805e6deda9955f2f3cce2997504
https://doi.org/10.1002/chin.200936097
https://doi.org/10.1002/chin.200936097
Autor:
Kevin D. Daze, Fraser Hof, Andreas Ibraheem, Thomas Pinter, Robert E. Campbell, Manuel C. F. Ma, Rebecca J. M. Courtemanche, Samuel A. Minaker, Cory S. Beshara
Publikováno v:
Chemical Science. 3:2695
Post-translational modifications of proteins (including phosphorylation, acetylation and methylation, among others) frequently carry out their biological functions by serving as ‘on’ switches for protein–protein interactions. As highly localize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94d31dcc048e34716b46b99dbef6e6da
https://doi.org/10.1039/c2sc20583a
https://doi.org/10.1039/c2sc20583a