MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration

Autor: Thomas Philips, Yevgeniya A. Mironova, Yan Jouroukhin, Jeannie Chew, Svetlana Vidensky, Mohamed H. Farah, Mikhail V. Pletnikov, Dwight E. Bergles, Brett M. Morrison, Jeffrey D. Rothstein

Publikováno v: Cell Reports, Vol 34, Iss 2, Pp 108610- (2021)

Summary: Oligodendrocytes (OLs) are important for myelination and shuttling energy metabolites lactate and pyruvate toward axons through their expression of monocarboxylate transporter 1 (MCT1). Recent studies suggest that loss of OL MCT1 causes axon

Externí odkaz: https://doaj.org/article/3365b3bdc34a429095f1971a8c5318cd

Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines

Autor: Ariane Pereira, Jeff A. Stogsdill, Gesine Saher, Peter Scheiffele, Lisa Traunmüller, Klaus-Armin Nave, Jiexin Wang, Chris J. McBain, Naosuke Hoshina, Huda Y. Zoghbi, Yu Itoh-Maruoka, Cagla Eroglu, Wei-Hsiang Huang, Fritz Benseler, Thomas Philips, Constance L. Cepko, Mateusz C. Ambrozkiewicz, Jeremy N. Kay, Hiroshi Kawabe, Vania F. Prado, Kevin T. Beier, Wenjia You, Nils Brose, Harold A. Burgess, Wei Lu, Junko Motohashi, Pascal S. Kaeser, Liqun Luo, Marco A. M. Prado, Elisabetta Furlanis, Emily Ling-Lin Pai, Kenji Sakimura, Kenji Mandai, John L.R. Rubenstein, Andrea M. Gomez, Emilie Dumontier, Michisuke Yuzaki, Hisashi Umemori, Yoshimi Takai, Jean-François Cloutier, Susanne Falkner, Laura A. Lavery, Sandra Goebbels, Matthijs Verhage, Ann Marie Craig, Cui Chen, Kenneth A. Pelkey, Wei Li, Nashat Abumaria, Joshua R. Sanes, Lin Luo, Jeffrey D. Rothstein, Joke Wortel, Jennifer L. Sinclair, Mary Anne Hutchison, Tomohiko Maruo

Publikováno v: Neuron, vol 106, iss 1
Luo, L, Ambrozkiewicz, M C, Benseler, F, Chen, C, Dumontier, E, Falkner, S, Furlanis, E, Gomez, A M, Hoshina, N, Huang, W H, Hutchison, M A, Itoh-Maruoka, Y, Lavery, L A, Li, W, Maruo, T, Motohashi, J, Pai, E L L, Pelkey, K A, Pereira, A, Philips, T, Sinclair, J L, Stogsdill, J A, Traunmüller, L, Wang, J, Wortel, J, You, W, Abumaria, N, Beier, K T, Brose, N, Burgess, H A, Cepko, C L, Cloutier, J F, Eroglu, C, Goebbels, S, Kaeser, P S, Kay, J N, Lu, W, Luo, L, Mandai, K, McBain, C J, Nave, K A, Prado, M A M, Prado, V F, Rothstein, J, Rubenstein, J L R, Saher, G, Sakimura, K, Sanes, J R, Scheiffele, P, Takai, Y, Umemori, H, Verhage, M, Yuzaki, M, Zoghbi, H Y, Kawabe, H & Craig, A M 2020, ' Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines : Prevalence of Germline Recombination and Influencing Factors ', Neuron, vol. 106, no. 1, pp. 37-65.e5 . https://doi.org/10.1016/j.neuron.2020.01.008
Neuron, 106(1), 37-65.e5. Cell Press
Neuron

The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a0d62fde17242aab3eee01b2747766
https://doi.org/10.1016/j.neuron.2020.01.008

Double-blind, placebo-controlled trial of mifepristone on cognition and depression in alcohol dependence

Autor: Thomas Philips, Colin Drummond, Joanna Milward, Simon Coulton, Kim Donoghue, Abigail K. Rose, Rachel Coleman, Hilary J. Little

Publikováno v: TRIALS
Trials
Trials, Vol 21, Iss 1, Pp 1-9 (2020)

Background Alcohol dependence is a significant issue contributing to disease burden. Changes in cortisol concentrations during alcohol withdrawal are associated with cognitive deficits and symptoms of depression. Current treatments are only successfu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a92ae384bd08d5f0e8881d036fdf12c

Uncloaking Campbell and Shiller’s CAPE: A Comprehensive Guide to Its Construction and Use

Autor: Thomas Philips, Cenk Ural

Publikováno v: The Journal of Portfolio Management. 43:109-125

Campbell and Shiller’s cyclically adjusted P/E (CAPE) has proven to be a powerful descriptor, and useful predictor, of long-term equity returns in the United States and some global markets. In recent years, though, it has been criticized for being

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040f9408e97395b31f815736a293f4cb
https://doi.org/10.3905/jpm.2016.43.1.109

Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis

Autor: Thomas Philips, Veerle Geelen, Kim A. Staats, André Bento-Abreu, Ludo Van Den Bosch, Benno Küsters, William D. Richardson, Wanda Haeck, Annelies Nonneman, Philip Van Damme, Wim Robberecht, Nicole Hersmus

Publikováno v: Brain; Vol 136
Brain, 136, 471-82
Brain, 136, Pt 2, pp. 471-82
Brain

Item does not contain fulltext Oligodendrocytes are well known targets for immune-mediated and infectious diseases, and have been suggested to play a role in neurodegeneration. Here, we report the involvement of oligodendrocytes and their progenitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3afb9e78ebd28d0d74bd7ae145e17f