Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thomas P. Nicholson"'
Akademický článek
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Autor:
Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas-Paz, Vanessa Orsini, Luigi M. Terracciano, Olga Charlat, Zinger Yang Loureiro, Lei Ji, Raffaella Zamponi, Frederic Sigoillot, Hong Lei, Alicia Lindeman, Carsten Russ, John S. Reece-Hoyes, Thomas B. Nicholson, Jan S. Tchorz, Feng Cong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
How cell-cell contact is sensed by Hippo pathway is poorly understood. Here, the authors show that KIRREL1 functions as a feedback regulator of the mammalian Hippo pathway by sensing cell-cell interaction and recruiting SAV1 to cell-cell contacts.
Externí odkaz:
https://doaj.org/article/bfe690555e05477e9caae7da26bcc89a
Autor:
Thomas A. Nicholson, Michael Sagmeister, Susanne N. Wijesinghe, Hussein Farah, Rowan S. Hardy, Simon W. Jones
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 237 (2023)
Age-related disorders of the musculoskeletal system including sarcopenia, osteoporosis and arthritis represent some of the most common chronic conditions worldwide, for which there remains a great clinical need to develop safer and more efficacious p
Externí odkaz:
https://doaj.org/article/3c50e07dfebf40e6ad3ecf4a810d2210
Autor:
Mark J. Pearson, Dietmar Herndler-Brandstetter, Mohammad A. Tariq, Thomas A. Nicholson, Ashleigh M. Philp, Hannah L. Smith, Edward T. Davis, Simon W. Jones, Janet M. Lord
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Increasing evidence suggests that inflammation plays a central role in driving joint pathology in certain patients with osteoarthritis (OA). Since many patients with OA are obese and increased adiposity is associated with chronic inflammatio
Externí odkaz:
https://doaj.org/article/5a0fee5425774d5baea88f5d9d04a355
Autor:
Mohammed Ahmed, David Breen, Cyrus Daneshvar, William Euan Falconer, Abdul Sibly, Madeleine Hindle, Thomas W Nicholson, Ghanem Aldik, Lilanganee A Telisinghe, Richard D Riordan, Adrian Marchbank
Publikováno v:
BMJ Open Respiratory Research, Vol 6, Iss 1 (2019)
Introduction Central airway obstruction (CAO) is a life-threatening complication of lung cancer. The prevalence of CAO in lung cancer patients is unknown. We audited CAO burden to inform our local cancer service.Methods This is a cohort review of all
Externí odkaz:
https://doaj.org/article/5aacc60578f041c1b4f786d1c3be0e0b
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Jacqueline Gire O’Rourke, Jaclyn R. Gareau, Joseph Ochaba, Wan Song, Tamás Raskó, David Reverter, John Lee, Alex Mas Monteys, Judit Pallos, Lisa Mee, Malini Vashishtha, Barbara L. Apostol, Thomas Peter Nicholson, Katalin Illes, Ya-Zhen Zhu, Mary Dasso, Gillian P. Bates, Marian Difiglia, Beverly Davidson, Erich E. Wanker, J. Lawrence Marsh, Christopher D. Lima, Joan S. Steffan, Leslie M. Thompson
Publikováno v:
Cell Reports, Vol 4, Iss 2, Pp 362-375 (2013)
A key feature in Huntington disease (HD) is the accumulation of mutant Huntingtin (HTT) protein, which may be regulated by posttranslational modifications. Here, we define the primary sites of SUMO modification in the amino-terminal domain of HTT, sh
Externí odkaz:
https://doaj.org/article/2cae4460f6614c9f87bd7c29ab921075
Autor:
Carolin Giannini, Alexander Kloß, Sabrina Gohlke, Michele Mishto, Thomas P Nicholson, Paul W Sheppard, Peter-Michael Kloetzel, Burkhardt Dahlmann
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64042 (2013)
Proteostasis is critical for the maintenance of life. In neuronal cells an imbalance between protein synthesis and degradation is thought to be involved in the pathogenesis of neurodegenerative diseases during aging. Partly, this seems to be due to a
Externí odkaz:
https://doaj.org/article/a35a41333648407d91fdc5a9b6e666b6
Autor:
Thomas B Nicholson, Anup K Singh, Hui Su, Sarah Hevi, Jing Wang, Jeff Bajko, Mei Li, Reginald Valdez, Margaret Goetschkes, Paola Capodieci, Joseph Loureiro, Xiaodong Cheng, En Li, Bernd Kinzel, Mark Labow, Taiping Chen
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60913 (2013)
Lysine-specific demethylase 1 (Lsd1/Aof2/Kdm1a), the first enzyme with specific lysine demethylase activity to be described, demethylates histone and non-histone proteins and is essential for mouse embryogenesis. Lsd1 interacts with numerous proteins
Externí odkaz:
https://doaj.org/article/9e1f88af16364c7b858f1fedc06057a6
Autor:
Paul W. Sheppard, Lijun Dai, Wayne F. Patton, Dee Shen, Thomas P. Nicholson, Eric Chan, Jack Coleman
Publikováno v:
Cell Biochemistry and Biophysics
Aggresomes and related inclusion bodies appear to serve as storage depots for misfolded and aggregated proteins within cells, which can potentially be degraded by the autophagy pathway. A homogenous fluorescence-based assay was devised to detect aggr