Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Thomas P. Misko"'
Autor:
Hari V. Kalluri, Matthew R. Rosebraugh, Thomas P. Misko, Adam Ziemann, Wei Liu, Bruce A. C. Cree
Publikováno v:
Annals of neurologyReferences.
This study was undertaken to describe the safety, tolerability, pharmacokinetics, and immunogenicity of elezanumab (ABT-555), a fully human monoclonal antibody (mAb) directed against repulsive guidance molecule A (RGMa), in healthy and multiple scler
Autor:
Rebecca Craig-Schapiro, Max Kuhn, Chengjie Xiong, Eve H Pickering, Jingxia Liu, Thomas P Misko, Richard J Perrin, Kelly R Bales, Holly Soares, Anne M Fagan, David M Holtzman
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18850 (2011)
Clinicopathological studies suggest that Alzheimer's disease (AD) pathology begins ∼10-15 years before the resulting cognitive impairment draws medical attention. Biomarkers that can detect AD pathology in its early stages and predict dementia onse
Externí odkaz:
https://doaj.org/article/e976640c1c5a4ccea2c12642381fa6f5
Autor:
Jon A. Klover, Francis M. Sverdrup, Lillian E. Vickery, Lily R.-H. Song, Charles P. Anglin, Thomas P. Misko, Matthew P. Yates
Publikováno v:
Osteoarthritis and Cartilage. 18(7):948-955
Summary Objective Statins possess anti-inflammatory properties. This study was undertaken to characterize the mechanism of action of statin drugs on collagenase expression in primary human osteoarthritic cartilage tissue. Method Human articular chond
Autor:
Olga V. Nemirovskiy, W. Rodney Mathews, Thomas P. Misko, Poonam Aggarwal, Melissa R. Radabaugh
Publikováno v:
Analytical Biochemistry. 380:68-76
Measurement of nitrotyrosine levels in biological fluids can serve as a biomarker for oxidative/nitrative damage arising from formation of reactive nitrogen species, including peroxynitrite. Peroxynitrite is formed by the reaction of the superoxide r
Autor:
Mark G. Currie, Zhi-Qiang Wang, Heather Macarthur, Thomas P. Misko, Dennis P. Riley, Patrick J. Lennon, Daniela Salvemini
Publikováno v:
British Journal of Pharmacology. 127:685-692
The relative contributions of superoxide anion (O2−) and peroxynitrite (PN) were evaluated in the pathogenesis of intestinal microvascular damage caused by the intravenous injection of E. coli lipopolysaccharide (LPS) in rats. The superoxide dismut
Autor:
Mark G. Currie, Karen B. Peterson, William M. Moore, Pamela T. Manning, Thomas P. Misko, Christine M. Kornmeier, Steven W. Kramer, Jane R. Connor, Gina M. Jerome, Barnett S. Pitzele, Mahima Trivedi, Foe S. Tjoeng, Donald W. Hansen, Ronald Keith Webber
Publikováno v:
Journal of Medicinal Chemistry. 41:1361-1366
An attractive approach to the treatment of inflammatory conditions such as osteo- and rheumatoid arthritis, inflammatory bowel disease, and sepsis is through the selective inhibition of human inducible nitric oxide synthase (hiNOS) since localized ex
Publikováno v:
Journal of Neuroimmunology. 80:121-130
Peroxynitrite, which is generated by the reaction of nitric oxide (NO) with superoxide, is a strong oxidant that can damage subcellular organelles, membranes and enzymes through its actions on proteins, lipids, and DNA, including the nitration of tyr
Autor:
Thomas P. Misko, Wanda S. LeJeune, T. Bruce Ferguson, Joseph R. Williamson, Patrick M. Sullivan, Kathy Chang, Neil K. Worrall
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 273:H2565-H2574
Tumor necrosis factor (TNF-α) and nitric oxide (NO) are important vasoactive mediators of septic shock. This study used a well-characterized quantitative permeation method to examine the effect of TNF-α and NO on systemic vascular barrier function
Autor:
O. Friese, M. Abrams, D. Roman, Candace Bramson, Thomas P. Misko, M.-P. Hellio Le Graverand, L.S. Lohmander, Melissa R. Radabaugh, Maureen K. Highkin, R. Gallavan
Publikováno v:
Osteoarthritis and Cartilage; 21(1), pp 151-156 (2013)
Misko, T P, Radabaugh, M R, Highkin, M, Abrams, M, Friese, O, Gallavan, R, Bramson, C, Hellio Le Graverand, M P, Lohmander, S & Roman, D 2013, ' Characterization of nitrotyrosine as a biomarker for arthritis and joint injury ', Osteoarthritis and Cartilage, vol. 21, no. 1, pp. 151-156 . https://doi.org/10.1016/j.joca.2012.09.005
Misko, T P, Radabaugh, M R, Highkin, M, Abrams, M, Friese, O, Gallavan, R, Bramson, C, Hellio Le Graverand, M P, Lohmander, S & Roman, D 2013, ' Characterization of nitrotyrosine as a biomarker for arthritis and joint injury ', Osteoarthritis and Cartilage, vol. 21, no. 1, pp. 151-156 . https://doi.org/10.1016/j.joca.2012.09.005
Objectives: To characterize the utility of nitrotyrosine (NT) as a biomarker for arthritis and joint injury. Design: Synovial fluid, plasma, and urine from patients diagnosed with osteoarthritis (OA), rheumatoid arthritis (RA), anterior cruciate liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9bb06451dd20cbef6c5c4d01efabe29
https://lup.lub.lu.se/record/3590089
https://lup.lub.lu.se/record/3590089
Autor:
Pamela S. Wyatt, Charles P. Rodi, Manuel San, Pamela T. Manning, Richard M. Keeling, Anne H. Cross, Salil Goorha, Thomas P. Misko
Publikováno v:
Journal of Neuroimmunology. 71:145-153
Messenger RNA encoding inducible NO synthase (iNOS) was measured by competitive reverse transcriptase polymerase chain reaction (cRT-PCR) and ribonuclease protection assays in spinal cords from mice at varying stages of experimental allergic encephal