Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Thomas P. McGee"'
Autor:
Ian D. Coombs, David Soto, Thomas P. McGee, Matthew G. Gold, Mark Farrant, Stuart G. Cull-Candy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
AMPA-type glutamate receptors, which mediate fast excitatory signaling throughout the brain, exhibit profound desensitization, causing a progressive current decline in the continued presence of agonist. Here authors show that homomeric Q/R edited AMP
Externí odkaz:
https://doaj.org/article/a50e120ec8be4c268b59eed05b410716
Autor:
Elizabeth C. Davenport, Valentina Pendolino, Georgina Kontou, Thomas P. McGee, David F. Sheehan, Guillermo López-Doménech, Mark Farrant, Josef T. Kittler
Publikováno v:
Cell Reports, Vol 21, Iss 1, Pp 70-83 (2017)
Inhibitory synaptic transmission requires the targeting and stabilization of GABAA receptors (GABAARs) at synapses. The mechanisms responsible remain poorly understood, and roles for transmembrane accessory proteins have not been established. Using m
Externí odkaz:
https://doaj.org/article/6314c57e64fa4530b58aaa74b48f5c0f
Autor:
David Soto, Ian D. Coombs, Matthew G. Gold, Stuart G. Cull-Candy, Thomas P. McGee, Mark Farrant
Desensitization is a canonical property of ligand-gated ion channels, causing progressive current decline in the continued presence of agonist. AMPA-type glutamate receptors, which mediate fast excitatory signaling throughout the brain, exhibit profo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7ac4632ca7ef99e33f1f58af5155e5
https://doi.org/10.1101/595009
https://doi.org/10.1101/595009
Publikováno v:
European Journal of Neuroscience. 28:759-770
Understanding the neurobiology of the transition from initial drug use to excessive drug use has been a challenge in drug addiction. We examined the effect of chronic 'binge' escalating dose cocaine administration, which mimics human compulsive drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f6e5bbc3448f41fe213e01c55b81e0
https://doi.org/10.1111/j.1460-9568.2008.06369.x
https://doi.org/10.1111/j.1460-9568.2008.06369.x
Publikováno v:
Frontiers in Neural Circuits, Vol 7 (2013)
We have made use of the delta subunit-selective allosteric modulator DS2 (4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl benzamide) to assay the contribution of delta-GABAARs to tonic and phasic conductance changes in the cerebellum, thalamus a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::dcfc3ba732072a0cec37146208bef56a
http://hdl.handle.net/10044/1/100678
http://hdl.handle.net/10044/1/100678
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(33)
Inhibition of GABAAreceptors by Cu2+has been appreciated for some time, but differences between synaptic and extrasynaptic GABAAreceptors have not been explored. We show that Cu2+potently blocks steady-state GABA currents mediated by extrasynaptic δ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c177de304c759a26f1ad481432fe0164
https://pubmed.ncbi.nlm.nih.gov/23946400
https://pubmed.ncbi.nlm.nih.gov/23946400
Autor:
Stephen G. Brickley, Elena Kutsarova, Catriona M. Houston, Alastair M. Hosie, Georgina MacKenzie, Thomas P. McGee, Nicholas P. Franks, Efthymia Diamanti, Pablo Mateos Rodriguez, Kevin Troyano-Cuturi
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(11)
High-affinity extrasynaptic GABAAreceptors are persistently activated by the low ambient GABA levels that are known to be present in extracellular space. The resulting tonic conductance generates a form of shunting inhibition that is capable of alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca6d0ef735f8c08eaa8b5d05bacd273
https://pubmed.ncbi.nlm.nih.gov/22423109
https://pubmed.ncbi.nlm.nih.gov/22423109
Autor:
Massimiliano Renzi, Georgina MacKenzie, Thomas P. McGee, Julian Bartram, Stephen G. Brickley, Alastair M. Hosie, Damian P. Bright, Mark Farrant
High-affinity extrasynaptic GABAAreceptors (GABAARs) are a prominent feature of cerebellar granule neurons and thalamic relay neurons. In both cell types, the presence of synaptic glomeruli would be expected to promote activation of these GABAARs, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc48a473c8b48c63167035ef72354f4
http://hdl.handle.net/11573/435489
http://hdl.handle.net/11573/435489
Autor:
William W. Olmsted, Thomas P. McGee
Publikováno v:
Radiology. 123:661-666
Most central nervous system aneurysms occur around the circle of Willis, and are congenital or arteriosclerotic in origin when in that location. Peripherally located aneurysms are either idiopathic or secondary to infection, tumor embolus (from chori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6563de4322ff1ecb32cce1458473ad52
https://doi.org/10.1148/123.3.661
https://doi.org/10.1148/123.3.661
Autor:
Thomas P. McGee, William W. Olmsted
Publikováno v:
Radiology. 123:375-377
Sixty-three cases of meningioma were selected for study. Radiologically, they were divided into blastic and cystic groups. Tumors producing more blastic patterns infrequently recurred, unlike those that contained a lytic factor. The cases were also a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b7bc038a6344722d1002c1f0c69a502
https://doi.org/10.1148/123.2.375
https://doi.org/10.1148/123.2.375