Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Thomas P. Loughran, Jr."'
Autor:
Mireia Casasampere, Johnson Ung, Alejandro Iñáñez, Carine Dufau, Kazuhito Tsuboi, Josefina Casas, Su-Fern Tan, David J. Feith, Nathalie Andrieu-Abadie, Bruno Segui, Thomas P. Loughran, Jr., José Luis Abad, Gemma Fabrias
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 3, Pp 100520- (2024)
Lipid amidases of therapeutic relevance include acid ceramidase (AC), N-acylethanolamine-hydrolyzing acid amidase, and fatty acid amide hydrolase (FAAH). Although fluorogenic substrates have been developed for the three enzymes and high-throughput me
Externí odkaz:
https://doaj.org/article/cbc54b7eb8e74f508add3ca8fe1b0079
Autor:
Li-Pin Kao, Samy A.F. Morad, Traci S. Davis, Matthew R. MacDougall, Miki Kassai, Noha Abdelmageed, Todd E. Fox, Mark Kester, Thomas P. Loughran, Jr., Jose' L. Abad, Gemma Fabrias, Su-Fern Tan, David J. Feith, David F. Claxton, Sarah Spiegel, Kelsey H. Fisher-Wellman, Myles C. Cabot
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 9, Pp 1590-1602 (2019)
The combination of daunorubicin (dnr) and cytarabine (Ara-C) is a cornerstone of treatment for acute myelogenous leukemia (AML); resistance to these drugs is a major cause of treatment failure. Ceramide, a sphingolipid (SL), plays a critical role in
Externí odkaz:
https://doaj.org/article/fd54fe2e27784a42b78f98d42562f8fa
Autor:
Su-Fern Tan, Wendy Dunton, Xin Liu, Todd E. Fox, Samy A.F. Morad, Dhimant Desai, Kenichiro Doi, Mark R. Conaway, Shantu Amin, David F. Claxton, Hong-Gang Wang, Mark Kester, Myles C. Cabot, David J. Feith, Thomas P. Loughran, Jr.
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1078-1086 (2019)
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. More than half of older AML patients fail to respond to cytotoxic chemotherapy, and most responders relapse with drug-resistant disease. Failure to achieve complete remission c
Externí odkaz:
https://doaj.org/article/a185154e7e4d47c99c08cbdef0bdcbba
Autor:
Samy A.F. Morad, Terence E. Ryan, P. Darrell Neufer, Tonya N. Zeczycki, Traci S. Davis, Matthew R. MacDougall, Todd E. Fox, Su-Fern Tan, David J. Feith, Thomas P. Loughran, Jr., Mark Kester, David F. Claxton, Brian M. Barth, Tye G. Deering, Myles C. Cabot
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 7, Pp 1231-1242 (2016)
The objective of our study was to determine the mechanism of action of the short-chain ceramide analog, C6-ceramide, and the breast cancer drug, tamoxifen, which we show coactively depress viability and induce apoptosis in human acute myelogenous leu
Externí odkaz:
https://doaj.org/article/9225c311082346768466937465b8333a
Autor:
Jorn L. J. C. Assmann, Leticia G. Leon, Christiaan J. Stavast, Sanne E. van den Bogaerdt, Joyce Schilperoord-Vermeulen, Yorick Sandberg, Mar Bellido, Stefan J. Erkeland, David J. Feith, Thomas P. Loughran Jr, Anton W. Langerak
Publikováno v:
Leukemia, 36. Nature Publishing Group
Leukemia, 36(4), 983-993. Nature Publishing Group
Leukemia, 36(4), 983-993. Nature Publishing Group
T-LGL cells arise as a consequence of chronic antigenic stimulation and inflammation and thrive because of constitutive activation of the STAT3 and ERK pathway. Notably, in 40% of patients, constitutive STAT3 activation is due to STAT3 activating mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbe792e0080c94f752304297c31470b
https://pure.eur.nl/en/publications/5f9453c3-f066-447b-80af-1c45f5f46d92
https://pure.eur.nl/en/publications/5f9453c3-f066-447b-80af-1c45f5f46d92
Publikováno v:
Leukemia Research Reports, Vol 4, Iss 1, Pp 4-7 (2015)
Large granular lymphocyte (LGL) leukemia is a chronic clonal lymphoproliferative disorder. Here, a T-LGL leukemia patient developed NK-LGL leukemia with residual leukemic T-LGL. TCRVβ usage and CDR3 sequence drifts were observed with disease progres
Externí odkaz:
https://doaj.org/article/ed5c5d7eb54e40a88e27745a8a279b74
Publikováno v:
eJHaem, Vol 3, Iss 3, Pp 919-923 (2022)
Abstract Large granular lymphocyte leukemia is a rare chronic lymphoproliferative disorder of cytotoxic cells. Other hematological malignancies such as CLL and multiple myeloma have been associated with poor vaccination response and markedly increase
Externí odkaz:
https://doaj.org/article/1ad749cb65a5430880773ac363014c38
Autor:
Kristine C. Olson, Katharine B. Moosic, Marieke K. Jones, Paige M. K. Larkin, Thomas L. Olson, Mariella F. Toro, Todd E. Fox, David J. Feith, Thomas P. Loughran Jr
Publikováno v:
Cancer Medicine, Vol 9, Iss 18, Pp 6533-6549 (2020)
Abstract Large granular lymphocyte (LGL) leukemia is a rare hematological disorder with expansion of the T‐cell or natural killer (NK) cell lineage. Signal transducer and activator of transcription 3 (STAT3) exhibits somatic activating mutations in
Externí odkaz:
https://doaj.org/article/bd39c179e95b40f8a87836e0597e7555
Autor:
Brian M. Barth, Weiyuan Wang, Paul T. Toran, Todd E. Fox, Charyguly Annageldiyev, Regina M. Ondrasik, Nicole R. Keasey, Timothy J. Brown, Viola G. Devine, Emily C. Sullivan, Andrea L. Cote, Vasiliki Papakotsi, Su-Fern Tan, Sriram S. Shanmugavelandy, Tye G. Deering, David B. Needle, Stephan T. Stern, Junjia Zhu, Jason Liao, Aaron D. Viny, David J. Feith, Ross L. Levine, Hong-Gang Wang, Thomas P. Loughran, Jr, Arati Sharma, Mark Kester, David F. Claxton
Publikováno v:
Blood Advances, Vol 3, Iss 17, Pp 2598-2603 (2019)
Externí odkaz:
https://doaj.org/article/c4625d35b02b4dee8bf8588d9b18b16d