Výsledky vyhledávání - "Thomas P. Kanyok"

Elevated gatifloxacin and reduced rifampicin concentrations in a single-dose interaction study amongst healthy volunteers

Autor: Pete Smith, Helen McIlleron, John R. Horton, P. Bernard Fourie, Thomas P. Kanyok, Jennifer Norman

Publikováno v: Journal of Antimicrobial Chemotherapy. 60:1398-1401

Objectives: Pharmacokinetic drug-drug interactions were investigated between the fluoroquinolone gatifloxacin and a fixed dose combination (FDC) of rifampicin, isoniazid and pyrazinamide. Patients and methods: The single-dose pharmacokinetics of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de727a008ff011055e67184817d04f97
https://doi.org/10.1093/jac/dkm393

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Strategic emphases for tropical diseases research: a TDR perspective

Autor: Erik Blas, Janis K. Lazdins, Robert G. Ridley, Fabio Zicker, Vasanthapuram Kumaraswami, Paul P. Nunn, Jane F. Kengeya Kayondo, Lester Chitsulo, Howard Engers, Ayoade Oduola, Philippe M.P. Desjeux, Carlos M. Morel, Jan H. F. Remme, Deborah W. Kioy, Thomas P. Kanyok, Yeya T. Toure

Publikováno v: Trends in Parasitology. 18:421-426

Setting priorities for health research is a difficult task, especially for the neglected diseases of the poor. A new approach to priority setting for tropical diseases research has been adopted by the UNDP/World Bank/WHO Special Programme for Researc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329f9ba1ea002abf5ab5c7f8fe8be015
https://doi.org/10.1016/s1471-4922(02)02387-5

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Pharmacokinetics of intramuscularly administered aminosidine in healthy subjects

Autor: Keith A. Rodvold, Larry H. Danziger, Aaron D. Killian, Thomas P. Kanyok

Publikováno v: Antimicrobial Agents and Chemotherapy. 41:982-986

Aminosidine is an older, broad-spectrum aminoglycoside antibiotic that has been shown to be effective in in vitro and animal models against multiple-drug-resistant tuberculosis and the Mycobacterium avium complex. The objective of this randomized, pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf110a749504781298b7c8499cb7d3a
https://doi.org/10.1128/aac.41.5.982

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In vivo activity of paromomycin against susceptible and multidrug-resistant Mycobacterium tuberculosis and M. avium complex strains

Autor: P.R.J. Gangadharam, J. Chinnaswamy, M.V. Reddy, Larry H. Danziger, Thomas P. Kanyok

Publikováno v: Antimicrobial Agents and Chemotherapy. 38:170-173

Encouraged by in vitro results, we have assessed the in vivo activity of paromomycin (PRM) against Mycobacterium tuberculosis, multidrug-resistant (MDR) M. tuberculosis (resistant to isoniazid, rifampin, and streptomycin), and Mycobacterium avium com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912fca6afc309a4b35078d4cd5a382d5
https://doi.org/10.1128/aac.38.2.170

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Early Bactericidal Activity of Paromomycin (Aminosidine) in Patients with Smear-Positive Pulmonary Tuberculosis

Autor: H. I. Seifart, D. P. Parkin, Peter R. Donald, Thomas P. Kanyok, Larry H. Danziger, F J Botha, F. A. Sirgel, B. W. Van de Wal, J. S. Maritz, D. A. Mitchison, Amour Venter

Publikováno v: Antimicrobial Agents and Chemotherapy. 44:3285-3287

The early bactericidal activity of the aminoglycoside paromomycin (aminosidine) in doses of 7.5 and 15 mg/kg of body weight was measured in 22 patients with previously untreated smear-positive pulmonary tuberculosis. The fall in log 10 CFU per millil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e349c25a2288e54c6bca474e25d0962
https://doi.org/10.1128/aac.44.12.3285-3287.2000

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Treatment of Cryptosporidial Diarrhea in an AIDS Patient with Paromomycin

Autor: Larry H. Danziger, Richard M. Novak, Thomas P. Kanyok

Publikováno v: Annals of Pharmacotherapy. 27:1460-1462

OBJECTIVE: To report a case of diarrhea caused by Cryptosporidium in an AIDS patient which was successfully treated with paromomycin. CASE SUMMARY: An AIDS patient with a 12-month history of Cryptosporidial diarrhea unresponsive to other treatment me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::554d8fa7e16090ba9028ded026bf2772
https://doi.org/10.1177/106002809302701209

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In-vitro synergy of paromomycin with metronidazole alone or metronidazole plus hydroxymetronidazole against Helicobacter pylori

Autor: Seonyoung Ryu, Thomas P. Kanyok, Susan L. Pendland, Larry H. Danziger, Joette M. Meyer

Publikováno v: The Journal of antimicrobial chemotherapy. 43(3)

The in-vitro activities of paromomycin and metronidazole alone or paromomycin and metronidazole plus hydroxymetronidazole (2:1 ratio) were studied against 19 Helicobacter pylori isolates using an in-vitro chequerboard technique. Partial synergy was d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65771ecc0757fcc202a551075eaf6dbd
https://pubmed.ncbi.nlm.nih.gov/10223597

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Determination of paromomycin in human plasma and urine by reversed-phase high-performance liquid chromatography using 2,4-dinitrofluorobenzene derivatization

Autor: Jie Lu, Michael J. Cwik, Thomas P. Kanyok

Publikováno v: Journal of chromatography. B, Biomedical sciences and applications. 695(2)

A sensitive high-performance liquid chromatographic method for the determination of paromomycin in human plasma and urine was developed. Paromomycin was quantitated following pre-column derivatization with 2,4-dinitrofluorobenzene (DNFB). The chromat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e34b610267577ed4c86484838aecd3e
https://pubmed.ncbi.nlm.nih.gov/9300869

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