Výsledky vyhledávání - "Thomas P. Huecksteadt"

NRF2 loss recapitulates heritable impacts of paternal cigarette smoke exposure

Autor: Dallin S. Broberg, Timothy G. Jenkins, Emma R. James, David Alonso, Thomas P. Huecksteadt, Kenneth I. Aston, James M. Hotaling, John R. Hoidal, Patrick J. Murphy, Jingtao Guo, Bradley R. Cairns, Douglas T. Carrell

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 16, Iss 6, p e1008756 (2020)

Paternal cigarette smoke (CS) exposure is associated with increased risk of behavioral disorders and cancer in offspring, but the mechanism has not been identified. Here we use mouse models to investigate mechanisms and impacts of paternal CS exposur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f17cffd5d64e7e850b42acf7af703f
http://europepmc.org/articles/PMC7307791

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Oxidative stress underlies heritable impacts of paternal cigarette smoke exposure

Autor: Jingtao Guo, Kenneth I. Aston, Thomas P. Huecksteadt, Emma R. James, James M. Hotaling, David Alonso, Patrick J. Murphy, Timothy G. Jenkins, D.T. Carrell, Brad R. Cairns, Hoidal, Dallin S. Broberg

SUMMARYPaternal cigarette smoke (CS) exposure is associated with increased risk of behavioral disorders and cancer in offspring, but the mechanism has not been identified. This study used mouse models to evaluate: 1) what impact paternal CS exposure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb399c5c072a8a86f55fa71e48ba2d94
https://doi.org/10.1101/750638

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NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-β1 and insulin-like growth factor binding protein-3

Autor: Anne Sturrock, Barbara C. Cahill, Kimberly Norman, Thomas P. Huecksteadt, John R. Hoidal, Karl Sanders, Ping Wu, Saleh Ismail, Thomas P. Kennedy

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 296:L489-L499

Persistent hypoxia can cause pulmonary arterial hypertension that may be associated with significant remodeling of the pulmonary arteries, including smooth muscle cell proliferation and hypertrophy. We previously demonstrated that the NADPH oxidase h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f51667cf833df3c6360f7379ed2c496
https://doi.org/10.1152/ajplung.90488.2008

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Nox4 mediates TGF-β1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells

Autor: Anne Sturrock, Thomas P. Kennedy, Kimberly Norman, Pasquale Chitano, Karl Sanders, John R. Hoidal, Thomas M. Murphy, Kimberly S Wilson, Thomas P. Huecksteadt

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 292:L1543-L1555

Transforming growth factor-beta1 (TGF-beta1) plays a pivotal role in increasing airway smooth muscle mass in severe asthma by inducing proliferation and hypertrophy of human airway smooth muscle. The mechanism(s) for these effects of TGF-beta1 have n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a0c981f10f6f82024ced830dbb60b2
https://doi.org/10.1152/ajplung.00430.2006

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NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells

Autor: Richelle Hemendinger, John R. Hoidal, Sukhdev S. Brar, Lisa R. Thornton, Anne Sturrock, Zachary Corbin, Rebecca S. Arnold, Kevin Krenitsky, A. Richard Whorton, Kristia G. Ardie, Thomas P. Huecksteadt, Mark T. Quinn, Thomas P. Kennedy, Bettina Bommarius, J. David Lambeth

Publikováno v: American Journal of Physiology-Cell Physiology. 285:C353-C369

Reactive oxygen species (ROS) appear to play an important role in regulating growth and survival of prostate cancer. However, the sources for ROS production in prostate cancer cells have not been determined. We report that ROS are generated by intact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9626d1d11973d758cbcd4e3000a5b7
https://doi.org/10.1152/ajpcell.00525.2002

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NADPH oxidase promotes NF-κB activation and proliferation in human airway smooth muscle

Autor: Anne Sturrock, Thomas M. Murphy, Sukhdev S. Brar, Thomas P. Kennedy, Pasquale Chitano, Thomas P. Huecksteadt, Mark T. Quinn, John R. Hoidal

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology. 282:L782-L795

Evidence is rapidly accumulating that low-activity-reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases homologous to that in phagocytic cells generate reactive oxygen species as signaling intermediates in both endothelium and vascula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0650244a18772ae1a591712c8ac1abf
https://doi.org/10.1152/ajplung.00206.2001

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Reactive oxygen species from NAD(P)H:quinone oxidoreductase constitutively activate NF-κB in malignant melanoma cells

Autor: Thomas P. Kennedy, Thomas P. Huecksteadt, Anne Sturrock, Sukhdev S. Brar, A. Richard Whorton, Andrew J. Ghio, John R. Hoidal

Publikováno v: American Journal of Physiology-Cell Physiology. 280:C659-C676

The transcription factor nuclear factor-κB (NF-κB) is constitutively activated in malignancies from enhanced activity of inhibitor of NF-κB (IκB) kinase, with accelerated IκBα degradation. We studied whether redox signaling might stimulate thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4ca483f12032a8a312b272e6215993
https://doi.org/10.1152/ajpcell.2001.280.3.c659

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