Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Thomas P. Garcia"'
Autor:
Courtney Sutton, Kaori Nozawa, Katarzyna Kent, Alexander Saltzman, Mei Leng, Sureshbabu Nagarajan, Anna Malovannaya, Masahito Ikawa, Thomas X. Garcia, Martin M. Matzuk
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The quest for a non-hormonal male contraceptive pill for men still exists. Serine protease 37 (PRSS37) is a sperm-specific protein that when ablated in mice renders them sterile. In this study we sought to examine the molecular sequelae of P
Externí odkaz:
https://doaj.org/article/5650f341af6d45c5a09035bc01695750
Autor:
Kaori Nozawa, Yoshitaka Fujihara, Darius J. Devlin, Ricardo E. Deras, Katarzyna Kent, Irina V. Larina, Kohei Umezu, Zhifeng Yu, Courtney M. Sutton, Qiuji Ye, Laura K. Dean, Chihiro Emori, Masahito Ikawa, Thomas X. Garcia, Martin M. Matzuk
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-19 (2022)
Abstract Background Ubiquitination is a post-translational modification required for a number of physiological functions regulating protein homeostasis, such as protein degradation. The endoplasmic reticulum (ER) quality control system recognizes and
Externí odkaz:
https://doaj.org/article/171dc70323894e62ae1682b013f60e38
Autor:
Yuki Oyama, Haruhiko Miyata, Keisuke Shimada, Yoshitaka Fujihara, Keizo Tokuhiro, Thomas X Garcia, Martin M Matzuk, Masahito Ikawa
Publikováno v:
Asian Journal of Andrology, Vol 24, Iss 3, Pp 266-272 (2022)
Gene expression analyses suggest that more than 1000–2000 genes are expressed predominantly in mouse and human testes. Although functional analyses of hundreds of these genes have been performed, there are still many testis-enriched genes whose fun
Externí odkaz:
https://doaj.org/article/7f88ba8a95df47dfb5206782c6123575
Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets
Autor:
Matthew J. Robertson, Katarzyna Kent, Nathan Tharp, Kaori Nozawa, Laura Dean, Michelle Mathew, Sandra L. Grimm, Zhifeng Yu, Christine Légaré, Yoshitaka Fujihara, Masahito Ikawa, Robert Sullivan, Cristian Coarfa, Martin M. Matzuk, Thomas X. Garcia
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-28 (2020)
Abstract Background The development of a safe, effective, reversible, non-hormonal contraceptive method for men has been an ongoing effort for the past few decades. However, despite significant progress on elucidating the function of key proteins inv
Externí odkaz:
https://doaj.org/article/0ca451ef67474a5f8bef91e98ab2ee87
Autor:
Eric Durot, Lukshe Kanagaratnam, Saurabh Zanwar, Efstathios Kastritis, Shirley D’Sa, Ramon Garcia-Sanz, Cécile Tomowiak, Bénédicte Hivert, Elise Toussaint, Caroline Protin, Jithma P. Abeykoon, Thomas Guerrero-Garcia, Gilad Itchaki, Josephine M. Vos, Anne-Sophie Michallet, Sophie Godet, Jehan Dupuis, Stéphane Leprêtre, Joshua Bomsztyk, Pierre Morel, Véronique Leblond, Steven P. Treon, Meletios A. Dimopoulos, Prashant Kapoor, Alain Delmer, Jorge J. Castillo
Publikováno v:
Haematologica, Vol 106, Iss 11 (2020)
Histological transformation into diffuse large B-cell lymphoma is a rare complication in patients with Waldenström macroglobulinemia (WM) and is usually associated with a poor prognosis. The objective of this study was to develop and validate a prog
Externí odkaz:
https://doaj.org/article/0931a2c3a1de4a5db0e8afca81e892d7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
With the continued steep rise of the global human population, and the paucity of safe and practical contraceptive options available to men, the need for development of effective and reversible non-hormonal methods of male fertility control is widely
Externí odkaz:
https://doaj.org/article/6d04f53a9b024033aea6eb26fdb0abcc
Autor:
Thomas P. Garcia, Gregory W. Sluggett, Michael P. Lynch, Nicholas Murray Thomson, Roger Nosal, Shirley Twohig, Schulz Darren John, Timothy J. N. Watson, Megan McMahon, Holly Bonsignore, Robert A. Singer, Paul Fitzsimons, Eileen A. Callaghan-Manning, Stephen T. Colgan, John G. Groskoph
Publikováno v:
Journal of Pharmaceutical Innovation. 8:67-71
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a60e11cf8c039021fff6e0a1643951a5
https://doi.org/10.1007/s12247-013-9150-5
https://doi.org/10.1007/s12247-013-9150-5
Autor:
Jonathan Coffman, Simon Cooper, Bernd Schuemmelfeder, Mary T. am Ende, Penny Butterell, Thomas P. Garcia, Timothy N. J. Watson, Kimberly Vukovinsky, Alex Chueh, Vincent McCurdy
Publikováno v:
Journal of Pharmaceutical Innovation. 7:13-18
Recent concerns about the applicability of design space boundaries developed on small scale to commercial manufacturing processes have been raised by regulators worldwide. These concerns center around the scalability of unit operations and their corr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2e178173b64608054cc56cf18082155
https://doi.org/10.1007/s12247-012-9123-0
https://doi.org/10.1007/s12247-012-9123-0
Autor:
Amit Banerjee, Thomas P. Garcia, Satish K. Singh, Carol F. Kirchhoff, Vince McCurdy, Roger Nosal
Publikováno v:
Pharmaceutical Dosage Forms-Parenteral Medications ISBN: 9781420086478
INTRODUCTION In August 2002, the FDA announced an initiative, Pharmaceutical Current Good Manufacturing Practices (CGMPs) for the 21st Century (1,2). The intent of this initiative was to modernize FDA’s regulation of the quality of pharmaceutical p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07d436b0cedef4ffb5e19636c762a95c
https://doi.org/10.3109/9781420086485-16
https://doi.org/10.3109/9781420086485-16
