Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Thomas P. Ellen"'
Autor:
Howard, Brenda S., Brown Jones, Fiona, Sellers Steenblock, Aundrea, Ham Butler, Kiersten, Thomas Laub, Ellen, Winters Crull, Meghan, Zaborowicz Grant, Katherine
Publikováno v:
Topics in Geriatric Rehabilitation; Jul-Sep2021, Vol. 37 Issue 3, p198-206, 9p
Autor:
Thomas P. Ellen, Xue Zhou, Jingxiang Bai, Xin Liu, Thomas J. Begley, Adriana Arita, Max Costa, Adrienne D. Kurtz, John P. Rooney, Wei Dai, Catherine B. Klein
Publikováno v:
Genomics. 94(5):294-307
We have used Saccharomyces cerevisiae to identify toxicologically important proteins and pathways involved in arsenic-induced toxicity and carcinogenicity in humans. We performed a systemic screen of the complete set of 4733 haploid S. cerevisiae sin
Publikováno v:
Carcinogenesis. 29:1831-1836
Arsenic (As) is a well-characterized human carcinogen but is generally not mutagenic. The evidence that As induces both loss of global DNA methylation and gene promoter DNA hypermethylation has suggested that epigenetic mechanisms may play an importa
Autor:
Thomas P. Ellen, K. E. Van Holde
Publikováno v:
Biochemistry. 43:7867-7872
The interaction of linker histone H1 with both linear and superhelical double-stranded DNA has been investigated at low ionic strengths. Gel mobility retardation experiments demonstrate strikingly different behavior for the two forms of DNA. First, t
Autor:
Catherine B. Klein, Xue Zhou, Adrienne D. Kurtz, Thomas P. Ellen, John P. Rooney, Jingxiang Bai, Thomas J. Begley, Wei Dai, Adriana Arita, Xin Liu, Max Costa
Publikováno v:
BMC Genomics
BMC Genomics, Vol 10, Iss 1, p 524 (2009)
BMC Genomics, Vol 10, Iss 1, p 524 (2009)
Background The understanding of the biological function, regulation, and cellular interactions of the yeast genome and proteome, along with the high conservation in gene function found between yeast genes and their human homologues, has allowed for S
Publikováno v:
Biochemistry. 48(21)
Chromatin is the natural state of protein-associated DNA in all eukaryotes. It is a dynamic polymer of subunits called nucleosomes. The nucleosome subunit consists of approximately 146 bps of DNA wrapped around an octamer of histone proteins. The his
Publikováno v:
Carcinogenesis. 29(6)
Nickel (Ni) is a known carcinogen, although the mechanism of its carcinogenicity is not clear. Here, we provide evidence that Ni can induce phosphorylation of histone H3 at its serine 10 residue in a c-jun N-terminal kinase (JNK)/stress-activated pro
Publikováno v:
Toxicology and applied pharmacology. 228(2)
Nickel (Ni) compounds are known carcinogens but underlying mechanisms are not clear. Epigenetic changes are likely to play an important role in nickel ion carcinogenesis. Previous studies have shown epigenetic effects of nickel ions, including the lo
Publikováno v:
Carcinogenesis. 29(1)
N-myc downstream-regulated gene 1 (NDRG1) is an intracellular protein that is induced under a wide variety of stress and cell growth-regulatory conditions. NDRG1 is up-regulated by cell differentiation signals in various cancer cell lines and suppres
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