Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Thomas P. C. Dorlo"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 3, Pp 374-385 (2024)
Abstract Adequate power to identify an exposure‐response relationship in a phase IIa clinical trial for pulmonary tuberculosis (TB) is important for dose selection and design of follow‐up studies. Currently, it is not known what response marker p
Externí odkaz:
https://doaj.org/article/788c8eff5be04e00aea81966e1e0d099
Autor:
David Damoiseaux, Frédéric Amant, Jos H. Beijnen, Shelby Barnett, Gareth J. Veal, Alwin D. R. Huitema, Thomas P. C. Dorlo
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 1931-1944 (2023)
Abstract Limited information is available concerning infant exposure and safety when breastfed by mothers receiving chemotherapy. Whereas defining distribution to breast milk is important to infer drug exposure, infant pharmacokinetics also determine
Externí odkaz:
https://doaj.org/article/af9a165e42b342d1ae831f5b5ee8be77
Autor:
David Damoiseaux, Alfred H. Schinkel, Jos H. Beijnen, Alwin D. R. Huitema, Thomas P. C. Dorlo
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 1, Pp n/a-n/a (2024)
Abstract First‐in‐human dose predictions are primarily based on no‐observed‐adverse‐effect levels in animal studies. Predictions from these animal models are only as effective as their ability to predict human results. To narrow the gap bet
Externí odkaz:
https://doaj.org/article/4492d5c59a174fd3b85d7757ccdc1918
Autor:
Hinke Siebinga, Berlinda J. de Wit-van der Veen, Jos H. Beijnen, Marcel P. M. Stokkel, Thomas P. C. Dorlo, Alwin D. R. Huitema, Jeroen J. M. A. Hendrikx
Publikováno v:
EJNMMI Physics, Vol 10, Iss 1, Pp 1-18 (2023)
Abstract Background Prediction of [177Lu]Lu-HA-DOTATATE kidney and tumor uptake based on diagnostic [68Ga]Ga-HA-DOTATATE imaging would be a crucial step for precision dosing of [177Lu]Lu-HA-DOTATATE. In this study, the population pharmacokinetic (PK)
Externí odkaz:
https://doaj.org/article/7d39074066094585b56c1d2b07482192
Autor:
Hinke Siebinga, Bastiaan M. Privé, Steffie M. B. Peters, James Nagarajah, Thomas P. C. Dorlo, Alwin D. R. Huitema, Berlinda J. deWit‐van der Veen, Jeroen J. M. A. Hendrikx
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 8, Pp 1060-1071 (2023)
Abstract Studies to evaluate and optimize [177Lu]Lu‐PSMA treatment focus primarily on individual patient data. A population pharmacokinetic (PK) dosimetry model was developed to explore the potential of using imaging data as input for population PK
Externí odkaz:
https://doaj.org/article/8669aa79881c42eab0d580af6a0f9877
Autor:
Hinke Siebinga, Berlinda J. de Wit-van der Veen, Jos H. Beijnen, Thomas P. C. Dorlo, Alwin D. R. Huitema, Jeroen J. M. A. Hendrikx
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Background Little is known about parameters that have a relevant impact on (dis)similarities in biodistribution between various 68Ga-labeled somatostatin analogues. Additionally, the effect of tumor burden on organ uptake remains unclear. Th
Externí odkaz:
https://doaj.org/article/76713150121a44bea16f200db7235fbf
Autor:
Julie M. Janssen, Remy B. Verheijen, Tirsa T. vanDuijl, Lishi Lin, Michel M. van denHeuvel, Jos H. Beijnen, Neeltje Steeghs, Daan van denBroek, Alwin D. R. Huitema, Thomas P. C. Dorlo
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 8, Pp 1916-1925 (2022)
Abstract Correlations between increasing concentrations of circulating tumor DNA (ctDNA) in plasma and disease progression have been shown. A nonlinear mixed effects model to describe the dynamics of epidermal growth factor receptor (EGFR) ctDNA data
Externí odkaz:
https://doaj.org/article/e9e8f2a318984775ba064c74fe28d765
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/23828b8ed45549e98b4efd9c4aa0bc8b
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/ff73c52437244d2d9391e9445d094bba
Autor:
David Damoiseaux, Wenlong Li, Alejandra Martínez-Chávez, Jos H. Beijnen, Alfred H. Schinkel, Alwin D. R. Huitema, Thomas P. C. Dorlo
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 860 (2022)
The extrapolation of drug exposure between species remains a challenging step in drug development, contributing to the low success rate of drug approval. As a consequence, extrapolation of toxicology from animal models to humans to evaluate safe, fir
Externí odkaz:
https://doaj.org/article/43a6e4f485c34a489be4e795886f503e