Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Thomas P. Burke"'
Autor:
Gina M. Borgo, Thomas P. Burke, Cuong J. Tran, Nicholas T. N. Lo, Patrik Engström, Matthew D. Welch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Pathogenic Rickettsia species are arthropod-borne, obligate intracellular bacteria that invade host cells, replicate in the cell cytosol, and spread from cell to cell. Here, Borgo et al. identify a Rickettsia phospholipase enzyme that is important fo
Externí odkaz:
https://doaj.org/article/76fc7169ff2a4a5fa9121ffd75dec244
Publikováno v:
mSphere, Vol 4, Iss 6 (2019)
ABSTRACT Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever. The bacteria have evolved a dependence on essential nutrients and me
Externí odkaz:
https://doaj.org/article/53f1d931ef4c45f28b2d436f73249013
Publikováno v:
mSphere, Vol 4, Iss 6 (2019)
Externí odkaz:
https://doaj.org/article/efeeeb2772f44258833317c5baa5968d
Autor:
Adelle P. McFarland, Thomas P. Burke, Alexie A. Carletti, Rochelle C. Glover, Hannah Tabakh, Matthew D. Welch, Joshua J. Woodward
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT The oxidoreductase RECON is a high-affinity cytosolic sensor of bacterium-derived cyclic dinucleotides (CDNs). CDN binding inhibits RECON’s enzymatic activity and subsequently promotes inflammation. In this study, we sought to characterize
Externí odkaz:
https://doaj.org/article/d0f59fdd2d6e471cbb8d6cd46b30c4e4
Autor:
Thomas P. Burke, Daniel A. Portnoy
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT In this study, we sought to characterize the targets of the abundant Listeria monocytogenes noncoding RNA Rli31, which is required for L. monocytogenes lysozyme resistance and pathogenesis. Whole-genome sequencing of lysozyme-resistant suppr
Externí odkaz:
https://doaj.org/article/0d0cd57f43ec4e67ba908630cd25e57b
Autor:
Chelsea E. Witte, Aaron T. Whiteley, Thomas P. Burke, John-Demian Sauer, Daniel A. Portnoy, Joshua J. Woodward
Publikováno v:
mBio, Vol 4, Iss 3 (2013)
ABSTRACT Listeria monocytogenes infection leads to robust induction of an innate immune signaling pathway referred to as the cytosolic surveillance pathway (CSP), characterized by expression of beta interferon (IFN-β) and coregulated genes. We previ
Externí odkaz:
https://doaj.org/article/494b505188234fde880cd6ecca82a394
Autor:
Emily R. Ko, Megan E. Reller, L. Gayani Tillekeratne, Champica K. Bodinayake, Cameron Miller, Thomas W. Burke, Ricardo Henao, Micah T. McClain, Sunil Suchindran, Bradly Nicholson, Adam Blatt, Elizabeth Petzold, Ephraim L. Tsalik, Ajith Nagahawatte, Vasantha Devasiri, Matthew P. Rubach, Venance P. Maro, Bingileki F. Lwezaula, Wasantha Kodikara-Arachichi, Ruvini Kurukulasooriya, Aruna D. De Silva, Danielle V. Clark, Kevin L. Schully, Deng Madut, J. Stephen Dumler, Cecilia Kato, Renee Galloway, John A. Crump, Geoffrey S. Ginsburg, Timothy D. Minogue, Christopher W. Woods
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Diagnostic limitations challenge management of clinically indistinguishable acute infectious illness globally. Gene expression classification models show great promise distinguishing causes of fever. We generated transcriptional data for a 2
Externí odkaz:
https://doaj.org/article/6b810e23001a49d88802db46e9e5c9d3
Autor:
Micah T. McClain, Ilya Zhbannikov, Lisa L. Satterwhite, Ricardo Henao, Nicholas S. Giroux, Shengli Ding, Thomas W. Burke, Ephraim L. Tsalik, Christina Nix, Jorge Prado Balcazar, Elizabeth A. Petzold, Xiling Shen, Christopher W. Woods
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108288- (2024)
Summary: To elucidate host response elements that define impending decompensation during SARS-CoV-2 infection, we enrolled subjects hospitalized with COVID-19 who were matched for disease severity and comorbidities at the time of admission. We perfor
Externí odkaz:
https://doaj.org/article/6e07d43e0da14020bb61da0c455e7171
Autor:
Paula Rauschendorf, Ghassan Bou Saba, Grace K. Meara, Navid Roodaki, Agustin Conde-Agudelo, Daisy Evangeline C. Garcia, Thomas F. Burke
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
AimTo examine the impact of introducing and implementing the Vayu bubble continuous positive airway pressure (bCPAP) system on neonatal survival and neonatal respiratory outcomes in a neonatal intensive care unit (NICU) in the Philippines.MethodsWe c
Externí odkaz:
https://doaj.org/article/e48937cc34124c849075224382be0578
Autor:
Nicholas S. Giroux, Shengli Ding, Micah T. McClain, Thomas W. Burke, Elizabeth Petzold, Hong A. Chung, Grecia O. Rivera, Ergang Wang, Rui Xi, Shree Bose, Tomer Rotstein, Bradly P. Nicholson, Tianyi Chen, Ricardo Henao, Gregory D. Sempowski, Thomas N. Denny, Maria Iglesias De Ussel, Lisa L. Satterwhite, Emily R. Ko, Geoffrey S. Ginsburg, Bryan D. Kraft, Ephraim L. Tsalik, Xiling Shen, Christopher W. Woods
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract SARS-CoV-2 infection triggers profound and variable immune responses in human hosts. Chromatin remodeling has been observed in individuals severely ill or convalescing with COVID-19, but chromatin remodeling early in disease prior to anti-sp
Externí odkaz:
https://doaj.org/article/734bc7f938d44704b53ab81adb346335