Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Thomas P. Brady"'
Autor:
María Hernández, Simon Dohrmann, James Levin, Nicholas Dedeic, Amanda Almaguer, Doug Zuill, Elizabeth Abelovski, Rajvir Grewal, Joanne Fortier, Qiping Zhao, Karin Amundson, Madison Moniz, Hongyuan Chen, Dhanya Panicker, Thanh Lam, Thomas P Brady, Allen Borchardt, Jason N Cole, Leslie W Tari
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/b93c42d0c77e42c1ac770d82acb13595
Autor:
Steven H. Liang, Daniel L. Yokell, Marc D. Normandin, Peter A. Rice, Raul N. Jackson, Timothy M. Shoup, Thomas J. Brady, Georges El Fakhri, Thomas L. Collier, Neil Vasdev
Publikováno v:
Molecular Imaging, Vol 13 (2014)
Despite extensive preclinical imaging with radiotracers developed by continuous-flow microfluidics, a positron emission tomographic (PET) radiopharmaceutical has not been reported for human imaging studies by this technology. The goal of this study w
Externí odkaz:
https://doaj.org/article/9337f32030384aeebaedb871c7a68b2a
Publikováno v:
Chemistry - A European Journal. 11:7175-7190
A stereoselective synthesis of (+)-norrisolide is presented. This natural product belongs to a family of marine spongiane diterpenes the structure of which is characterized by a fused gamma-lactone-gamma-lactol ring system attached to a bicyclic hydr
Autor:
Emmanuel A. Theodorakis, Mark A. Haidekker, Walter J. Akers, Thomas P. Brady, Darcy J. Lichlyter
Publikováno v:
Sensor Letters. 3:42-48
Molecular rotors are fluorescent molecules with two competing pathways of deexcitation: They return from the excited singlet state to the ground state either through fluorescence or through nonradiative intramolecular rotation. Molecular rotors are k
Synthesis of Fused Tetrahydrofuran‐γ‐lactone Motifs via One‐Pot Ring Expansion of Cyclopropane Rings
Publikováno v:
Synthetic Communications. 34:1951-1965
An efficient method for constructing fused tetrahydrofuran‐γ‐lactone scaffolds, such as 8, is presented. Key to this strategy is an acid‐catalyzed ring expansion of cyclopropyl precursor 6 that proceeds in the presence of MeSO3H in acetone and
Autor:
Hazel Y. Stevens, Mark A. Haidekker, Thomas P. Brady, Amy G. Tsai, John A. Frangos, Emmanuel A. Theodorakis, Marcos Intaglietta
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 282:H1609-H1614
Molecular rotors, a group of fluorescent molecules with viscosity-dependent quantum yield, were tested for their suitability to act as fluorescence-based plasma viscometers. The viscosity of samples of human plasma was modified by the addition of pen
The cellular activity of norrisolide (7), a novel Golgi-vesiculating agent, was dissected as function of its chemical structure. This natural product induces irreversible vesiculation of the Golgi membranes and blocks protein transport at the level o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b5d3fd49c8fb8558c254ba167d15aa
https://europepmc.org/articles/PMC2838712/
https://europepmc.org/articles/PMC2838712/
Inspired by the effect of norrisolide on the Golgi complex, we synthesized norrisolide probes that contain: the perhydroindane core of the parent natural product for Golgi localization, a crosslinking unit (aryl azide or epoxide) for covalent binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5c6c455a9b7d543dad0c8adb53d6bc
https://europepmc.org/articles/PMC1853282/
https://europepmc.org/articles/PMC1853282/
Publikováno v:
Journal of the American Chemical Society. 128(13)
The chemical origin of the norrisolide-induced irreversible Golgi vesiculation was studied using a variety of norrisolide probes. This natural product was found to bind to a receptor on the Golgi membranes using the perhydroindane core fragment as th
Autor:
Bo Liang, Adam D. Richardson, James J. La Clair, Thomas P. Brady, Matthew D Alexander, Joel S. Sandler, Santosh J. Gharpure, Alexei Polosukhin, Hai Ren Zhang, Xiaobin Ding, Madeleine M. Joullié, A. Richard Chamberlin, Chris M. Ireland, James B. Aggen, Brian M. Gulledge, Mary Kay Harper, Michael D. Burkart, P. Andrew Evans, Binh G. Vong, William Fenical, Padma Portonovo, Emmanuel A. Theodorakis, Michael S. Leonard, Jian Cui
Publikováno v:
Chembiochem : a European journal of chemical biology. 7(3)
A Central Strategy for Converting Natural Products into Fluorescent Probes Matthew D. Alexander, Michael D. Burkart, Michael S. Leonard, Padma Portonovo, Bo Liang, Xiaobin Ding, Madeleine M. Joulli!, Brian M. Gulledge, James B. Aggen, A. Richard Cham