Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Thomas P Stratton"'
Autor:
Sean Ekins, Daniel Mietchen, Megan Coffee, Thomas P Stratton, Joel S Freundlich, Lucio Freitas-Junior, Eugene Muratov, Jair Siqueira-Neto, Antony J Williams, Carolina Andrade
Publikováno v:
F1000Research, Vol 5 (2016)
The Zika virus (ZIKV) outbreak in the Americas has caused global concern that we may be on the brink of a healthcare crisis. The lack of research on ZIKV in the over 60 years that we have known about it has left us with little in the way of starting
Externí odkaz:
https://doaj.org/article/a25d8021d75548d2a69e93f71fdc0e14
Autor:
Sean Ekins, Peter B Madrid, Malabika Sarker, Shao-Gang Li, Nisha Mittal, Pradeep Kumar, Xin Wang, Thomas P Stratton, Matthew Zimmerman, Carolyn Talcott, Pauline Bourbon, Mike Travers, Maneesh Yadav, Joel S Freundlich
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141076 (2015)
Integrated computational approaches for Mycobacterium tuberculosis (Mtb) are useful to identify new molecules that could lead to future tuberculosis (TB) drugs. Our approach uses information derived from the TBCyc pathway and genome database, the Col
Externí odkaz:
https://doaj.org/article/ba8bcfee67d346ddae5ce987ea3cb3cf
Autor:
Shao-Gang Li, Alexander L. Perryman, Alex Lemenze, Sean Ekins, Steve D. Paget, Pradeep Kumar, Xin Wang, Thomas P. Stratton, Joel S. Freundlich, Arthur J. Olson
Publikováno v:
ACS Infectious Diseases. 5:2148-2163
Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), kills 1.6 million people annually. To bridge the gap between structure- and cell-based drug discovery strategies, we are pionee...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b6e3505194ba3afaeb6a2674ce9ff0e
https://doi.org/10.1021/acsinfecdis.9b00295
https://doi.org/10.1021/acsinfecdis.9b00295
Publikováno v:
Journal of the American Chemical Society. 141:29-32
A simple total synthesis of herqulines B and C is reported, modeled on the reductive biosynthesis reported previously by other researchers. Commencing from tyrosine, these alkaloids were fashioned through a dimerization, macrocyclization, and four co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ff1fe85ad767579b30329c798cfbb2
https://doi.org/10.1021/jacs.8b13029
https://doi.org/10.1021/jacs.8b13029
Autor:
Cody Ross Pitts, Thomas P. Stratton, Kyle S McClymont, Cheng Bi, Phil S. Baran, David S. Peters
Publikováno v:
Acc Chem Res
Total synthesis-the ultimate proving ground for the invention and field-testing of new methods, exploration of disruptive strategies, final structure confirmation, and empowerment of medicinal chemistry on natural products-is one of the oldest and mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78feccb6ad288ed0b6af63fb0783f739
https://europepmc.org/articles/PMC7870344/
https://europepmc.org/articles/PMC7870344/
Autor:
Chi He, Phil S. Baran, Thomas P. Stratton, David Kossler, Hang Chu, Kelly J. Eberle, Dillon T. Flood
Publikováno v:
J Am Chem Soc
The intriguing structure of tagetitoxin (1), a long-standing challenge in natural product synthesis, has been the subject of multiple revisions and has been confirmed through total synthesis. The route commences from a renewable furan starting materi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f37b559face2540628f98d6c6280678
https://europepmc.org/articles/PMC8353664/
https://europepmc.org/articles/PMC8353664/
Autor:
Xin, Wang, Alexander L, Perryman, Shao-Gang, Li, Steve D, Paget, Thomas P, Stratton, Alex, Lemenze, Arthur J, Olson, Sean, Ekins, Pradeep, Kumar, Joel S, Freundlich
Publikováno v:
ACS Infect Dis
Tuberculosis, caused by Mycobacterium tuberculosis (M. tuberculosis), kills 1.6 million people annually. To bridge the gap between structure- and cell-based drug discovery strategies, we are pioneering a computer-aided discovery paradigm that merges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17edbe8f24cd19d28f2b1fff444eb547
https://pubmed.ncbi.nlm.nih.gov/31625383
https://pubmed.ncbi.nlm.nih.gov/31625383
Autor:
Thomas P. Stratton, Patricia Soteropoulos, Joel S. Freundlich, Xin Wang, Hsin Pin Ho, Srinivasan Kandasamy, Seema Hussain, Alejandro Davila-Pagan, Ravindra Jadhav, Daigo Inoyama, Nisha Mittal, Eric Singleton, Sean Ekins, Véronique Dartois, Richard Pottorf, Yong Mo Ahn, Pradeep Kumar, Riccardo Russo, Joseph A. Bilotta, Matthew D. Zimmerman, Courtney Grady, Nancy D. Connell, Thomas J. Kim, Steve D. Paget, Steven Park, Shao-Gang Li
Publikováno v:
Cell Chem Biol
Summary The triazine antitubercular JSF-2019 was of interest due to its in vitro efficacy and the nitro group shared with the clinically relevant delamanid and pretomanid. JSF-2019 undergoes activation requiring F420H2 and one or more nitroreductases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef40c52dd7e436750e1c5e66319649f9
https://doi.org/10.1016/j.chembiol.2019.10.010
https://doi.org/10.1016/j.chembiol.2019.10.010
Autor:
William R. Jacobs, Nancy D. Connell, Sean Ekins, Eric Singleton, Shao-Gang Li, Riccardo Russo, Thomas P. Stratton, Catherine Vilchèze, Alexander L. Perryman, Joel S. Freundlich, Jimmy Patel
Publikováno v:
ACS medicinal chemistry letters. 8(10)
We present the first prospective application of our mouse liver microsomal (MLM) stability Bayesian model. CD117, an antitubercular thienopyrimidine tool compound that suffers from metabolic instability (MLM t1/2 < 1 min), was utilized to assess the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2621e5188865e24e8295d964824f47e4
https://pubmed.ncbi.nlm.nih.gov/29057058
https://pubmed.ncbi.nlm.nih.gov/29057058
Mouse efficacy studies are a critical hurdle to advance translational research of potential therapeutic compounds for many diseases. Although mouse liver microsomal (MLM) stability studies are not a perfect surrogate for in vivo studies of metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298d0d96b5f6d15b50c96c2c9e43c48a
https://europepmc.org/articles/PMC4712113/
https://europepmc.org/articles/PMC4712113/