Výsledky vyhledávání - "Thomas P O'Neil"

Akademický článek

Characterising plasmacytoid and myeloid AXL+ SIGLEC-6+ dendritic cell functions and their interactions with HIV.

Autor: Freja A Warner van Dijk, Orion Tong, Thomas R O'Neil, Kirstie M Bertram, Kevin Hu, Heeva Baharlou, Erica E Vine, Kate Jenns, Martijn P Gosselink, James W Toh, Tim Papadopoulos, Laith Barnouti, Gregory J Jenkins, Gavin Sandercoe, Muzlifah Haniffa, Kerrie J Sandgren, Andrew N Harman, Anthony L Cunningham, Najla Nasr

Publikováno v: PLoS Pathogens, Vol 20, Iss 6, p e1012351 (2024)

AXL+ Siglec-6+ dendritic cells (ASDC) are novel myeloid DCs which can be subdivided into CD11c+ and CD123+ expressing subsets. We showed for the first time that these two ASDC subsets are present in inflamed human anogenital tissues where HIV transmi

Externí odkaz: https://doaj.org/article/1e4028ffe06646b1b34da8e1a361e6ce

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Akademický článek

Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccines

Autor: Erica Elizabeth Vine, Paul Jonathon Austin, Thomas Ray O’Neil, Najla Nasr, Kirstie Melissa Bertram, Anthony Lawrence Cunningham, Andrew Nicholas Harman

Publikováno v: Cell Reports, Vol 43, Iss 4, Pp 113977- (2024)

Summary: Next-generation vaccines may be delivered via the skin and mucosa. The stratified squamous epithelium (SSE) represents the outermost layer of the skin (epidermis) and type II mucosa (epithelium). Langerhans cells (LCs) have been considered t

Externí odkaz: https://doaj.org/article/c0d22c2785c440fcb48fd547a91ce575

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Akademický článek

Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendrit

Externí odkaz: https://doaj.org/article/3840bd9c9273487999b88e2c53427e0d

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Akademický článek

Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype.

Autor: Orion Tong, Gabriel Duette, Thomas R O'Neil, Caroline M Royle, Hafsa Rana, Blake Johnson, Nicole Popovic, Suat Dervish, Michelle A E Brouwer, Heeva Baharlou, Ellis Patrick, Grahame Ctercteko, Sarah Palmer, Eunok Lee, Eric Hunter, Andrew N Harman, Anthony L Cunningham, Najla Nasr

Publikováno v: PLoS Pathogens, Vol 17, Iss 4, p e1009522 (2021)

Although HIV infection inhibits interferon responses in its target cells in vitro, interferon signatures can be detected in vivo soon after sexual transmission, mainly attributed to plasmacytoid dendritic cells (pDCs). In this study, we examined the

Externí odkaz: https://doaj.org/article/ac8d0f3bc05e48a0b188ee8f2bad653c

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Akademický článek

The Role of Tissue Resident Memory CD4 T Cells in Herpes Simplex Viral and HIV Infection

Autor: Thomas R. O’Neil, Kevin Hu, Naomi R. Truong, Sana Arshad, Barbara L. Shacklett, Anthony L. Cunningham, Najla Nasr

Publikováno v: Viruses, Vol 13, Iss 3, p 359 (2021)

Tissue-resident memory T cells (TRM) were first described in 2009. While initially the major focus was on CD8+ TRM, there has recently been increased interest in defining the phenotype and the role of CD4+ TRM in diseases. Circulating CD4+ T cells se

Externí odkaz: https://doaj.org/article/0df9304bb510409fb5bbd48137c6f05a

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