Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thomas P Nicholson"'
Autor:
Carolin Giannini, Alexander Kloß, Sabrina Gohlke, Michele Mishto, Thomas P Nicholson, Paul W Sheppard, Peter-Michael Kloetzel, Burkhardt Dahlmann
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64042 (2013)
Proteostasis is critical for the maintenance of life. In neuronal cells an imbalance between protein synthesis and degradation is thought to be involved in the pathogenesis of neurodegenerative diseases during aging. Partly, this seems to be due to a
Externí odkaz:
https://doaj.org/article/a35a41333648407d91fdc5a9b6e666b6
Akademický článek
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Autor:
Thomas A. Nicholson, Michael Sagmeister, Susanne N. Wijesinghe, Hussein Farah, Rowan S. Hardy, Simon W. Jones
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 237 (2023)
Age-related disorders of the musculoskeletal system including sarcopenia, osteoporosis and arthritis represent some of the most common chronic conditions worldwide, for which there remains a great clinical need to develop safer and more efficacious p
Externí odkaz:
https://doaj.org/article/3c50e07dfebf40e6ad3ecf4a810d2210
Autor:
Mohammed Ahmed, David Breen, Cyrus Daneshvar, William Euan Falconer, Abdul Sibly, Madeleine Hindle, Thomas W Nicholson, Ghanem Aldik, Lilanganee A Telisinghe, Richard D Riordan, Adrian Marchbank
Publikováno v:
BMJ Open Respiratory Research, Vol 6, Iss 1 (2019)
Introduction Central airway obstruction (CAO) is a life-threatening complication of lung cancer. The prevalence of CAO in lung cancer patients is unknown. We audited CAO burden to inform our local cancer service.Methods This is a cohort review of all
Externí odkaz:
https://doaj.org/article/5aacc60578f041c1b4f786d1c3be0e0b
Akademický článek
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Autor:
Jacqueline Gire O’Rourke, Jaclyn R. Gareau, Joseph Ochaba, Wan Song, Tamás Raskó, David Reverter, John Lee, Alex Mas Monteys, Judit Pallos, Lisa Mee, Malini Vashishtha, Barbara L. Apostol, Thomas Peter Nicholson, Katalin Illes, Ya-Zhen Zhu, Mary Dasso, Gillian P. Bates, Marian Difiglia, Beverly Davidson, Erich E. Wanker, J. Lawrence Marsh, Christopher D. Lima, Joan S. Steffan, Leslie M. Thompson
Publikováno v:
Cell Reports, Vol 4, Iss 2, Pp 362-375 (2013)
A key feature in Huntington disease (HD) is the accumulation of mutant Huntingtin (HTT) protein, which may be regulated by posttranslational modifications. Here, we define the primary sites of SUMO modification in the amino-terminal domain of HTT, sh
Externí odkaz:
https://doaj.org/article/2cae4460f6614c9f87bd7c29ab921075
Autor:
Paul W. Sheppard, Lijun Dai, Wayne F. Patton, Dee Shen, Thomas P. Nicholson, Eric Chan, Jack Coleman
Publikováno v:
Cell Biochemistry and Biophysics
Aggresomes and related inclusion bodies appear to serve as storage depots for misfolded and aggregated proteins within cells, which can potentially be degraded by the autophagy pathway. A homogenous fluorescence-based assay was devised to detect aggr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372cc14fb6ec29baab19c12d693ac751
http://europepmc.org/articles/PMC3112480
http://europepmc.org/articles/PMC3112480
Autor:
Hans Häcker, Thomas P. Nicholson, Cliff Guy, Dario A. A. Vignali, Atsushi Matsuzawa, Ping Hui Tseng, Scott A. Brown, Haopeng Wang, Paul W. Sheppard, Karen Forbes, Jingran Zhou, Michael Karin
Publikováno v:
Proceedings of the National Academy of Sciences. 105:20197-20202
Modification of proteins by the addition of lysine (K)-63-linked polyubiquitin (polyUb) chains is suggested to play important roles in a variety of cellular events, including DNA repair, signal transduction, and receptor endocytosis. However, identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a557e757c05d6c7c6c20ee3c066c461e
https://doi.org/10.1073/pnas.0810461105
https://doi.org/10.1073/pnas.0810461105
Autor:
Malgorzata E. Jarzabek, Russell J. Cox, James Westcott, Thomas J. Simpson, Anna E. Szafranska, Michelle A. C. Reed, Florilène Soulas, Oliver Daltrop, John Crosby, Leah H. Smith, Thomas P. Nicholson, Frank Glod
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1644-1649
Streptomyces coelicolor is host to a number of biosynthetic proteins requiring post-translational modification by the addition of phosphopantetheine groups. The S. coelicolor genome, was probed, in silico, with the sequence of Escherichia coliholo-Ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22e33afa4f73bce858b2ff9b8326d487
https://doi.org/10.1039/b204633b
https://doi.org/10.1039/b204633b
Autor:
John Crosby, Thomas J. Simpson, Matthew P. Crump, Michael Schweizer, Michelle A. C. Reed, Russell J. Cox, Thomas P. Nicholson, Anna E. Szafranska, Christopher J. Arthur
Publikováno v:
Organicbiomolecular chemistry. 1(3)
While X-ray and NMR structures are now available for most components of the Type II fatty acid synthase (FAS), there are no structures for Type I FAS domains. A region from the mammalian (rat) FAS, including the putative acyl carrier protein (ACP), h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c440d9e74e82a85249be8feec3149a3
https://pubmed.ncbi.nlm.nih.gov/12926246
https://pubmed.ncbi.nlm.nih.gov/12926246