Zobrazeno 1 - 10
of 465
pro vyhledávání: '"Thomas P Conrads"'
Autor:
Laura E. Johnston, Jamie Randall, Safae Chouraichi, Mary Luu, Allison L. Hunt, Lauren Mauro, Claudius Mueller, Justin B. Davis, Emanuel F. Petricoin, Thomas P. Conrads, Timothy L. Cannon, Jasmine Huynh
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-7 (2024)
Abstract Recent trials have shown the efficacy of trastuzumab deruxtecan (T-DXd) in HER2-negative patients, but there is not yet a way to identify which patients will best respond, especially with the inability of current HER2 IHC and FISH assays to
Externí odkaz:
https://doaj.org/article/62cf1a759ec3482aa0239484568040b5
Autor:
Nicholas W. Bateman, Tamara Abulez, Anthony R. Soltis, Andrew McPherson, Seongmin Choi, Dale W. Garsed, Ahwan Pandey, Chunqiao Tian, Brian L. Hood, Kelly A. Conrads, Pang-ning Teng, Julie Oliver, Glenn Gist, Dave Mitchell, Tracy J. Litzi, Christopher M. Tarney, Barbara A. Crothers, Paulette Mhawech-Fauceglia, Clifton L. Dalgard, Matthew D. Wilkerson, Mariaelena Pierobon, Emanuel F. Petricoin, Chunhua Yan, Daoud Meerzaman, Clara Bodelon, Nicolas Wentzensen, Jerry S. H. Lee, The APOLLO Research Network, David G. Huntsman, Sohrab Shah, Craig D. Shriver, Neil T. Phippen, Kathleen M. Darcy, David D. L. Bowtell, Thomas P. Conrads, G. Larry Maxwell
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-17 (2024)
Abstract We performed a deep proteogenomic analysis of bulk tumor and laser microdissection enriched tumor cell populations from high-grade serous ovarian cancer (HGSOC) tissue specimens spanning a broad spectrum of purity. We identified patients wit
Externí odkaz:
https://doaj.org/article/24fb205468404dc8816ab7d41beb50e4
Autor:
Thomas Buddenkotte, Leonardo Rundo, Ramona Woitek, Lorena Escudero Sanchez, Lucian Beer, Mireia Crispin-Ortuzar, Christian Etmann, Subhadip Mukherjee, Vlad Bura, Cathal McCague, Hilal Sahin, Roxana Pintican, Marta Zerunian, Iris Allajbeu, Naveena Singh, Anju Sahdev, Laura Havrilesky, David E. Cohn, Nicholas W. Bateman, Thomas P. Conrads, Kathleen M. Darcy, G. Larry Maxwell, John B. Freymann, Ozan Öktem, James D. Brenton, Evis Sala, Carola-Bibiane Schönlieb
Publikováno v:
European Radiology Experimental, Vol 7, Iss 1, Pp 1-10 (2023)
Abstract Purpose To determine if pelvic/ovarian and omental lesions of ovarian cancer can be reliably segmented on computed tomography (CT) using fully automated deep learning-based methods. Methods A deep learning model for the two most common disea
Externí odkaz:
https://doaj.org/article/d86351df71064c6098a739ef36b913d9
Autor:
Michelle Barbi de Moura, Garret Vincent, Shelley L Fayewicz, Nicholas W Bateman, Brian L Hood, Mai Sun, Joseph Suhan, Stefan Duensing, Yan Yin, Cindy Sander, John M Kirkwood, Dorothea Becker, Thomas P Conrads, Bennett Van Houten, Stergios J Moschos
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e40690 (2012)
The importance of mitochondria as oxygen sensors as well as producers of ATP and reactive oxygen species (ROS) has recently become a focal point of cancer research. However, in the case of melanoma, little information is available to what extent cell
Externí odkaz:
https://doaj.org/article/72cadaeade94434ba5ad00dba5a37a23
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25056 (2011)
BACKGROUND:Epithelial ovarian cancer (EOC) is the deadliest gynecologic malignancy in the United States. Unfortunately, a validated protein biomarker-screening test to detect early stage disease from peripheral blood has not yet been developed. The p
Externí odkaz:
https://doaj.org/article/9d62d7806db242e1ba4e3b18ebcace84
Autor:
Pang-ning Teng, Joshua P. Schaaf, Tamara Abulez, Brian L. Hood, Katlin N. Wilson, Tracy J. Litzi, David Mitchell, Kelly A. Conrads, Allison L. Hunt, Victoria Olowu, Julie Oliver, Fred S. Park, Marshé Edwards, AiChun Chiang, Matthew D. Wilkerson, Praveen-Kumar Raj-Kumar, Christopher M. Tarney, Kathleen M. Darcy, Neil T. Phippen, G. Larry Maxwell, Thomas P. Conrads, Nicholas W. Bateman
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109198- (2024)
Summary: Numerous multi-omic investigations of cancer tissue have documented varying and poor pairwise transcript:protein quantitative correlations, and most deconvolution tools aiming to predict cell type proportions (cell admixture) have been devel
Externí odkaz:
https://doaj.org/article/87a62e3f792e48a18b676967436cc62a
Autor:
Sara Corvigno, Sunil Badal, Meredith L. Spradlin, Michael Keating, Igor Pereira, Elaine Stur, Emine Bayraktar, Katherine I. Foster, Nicholas W. Bateman, Waleed Barakat, Kathleen M. Darcy, Thomas P. Conrads, G. Larry Maxwell, Philip L. Lorenzi, Susan K. Lutgendorf, Yunfei Wen, Li Zhao, Premal H. Thaker, Michael J. Goodheart, Jinsong Liu, Nicole Fleming, Sanghoon Lee, Livia S. Eberlin, Anil K. Sood
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-26 (2023)
Abstract In this study, we investigated the metabolic alterations associated with clinical response to chemotherapy in patients with ovarian cancer. Pre- and post-neoadjuvant chemotherapy (NACT) tissues from patients with high-grade serous ovarian ca
Externí odkaz:
https://doaj.org/article/6cd6335bee5943da92c6a3557efb08a7
Autor:
John P. McGee, Pei Su, Kenneth R. Durbin, Michael A. R. Hollas, Nicholas W. Bateman, G. Larry Maxwell, Thomas P. Conrads, Ryan T. Fellers, Rafael D. Melani, Jeannie M. Camarillo, Jared O. Kafader, Neil L. Kelleher
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The molecular identification of tissue proteoforms by top-down mass spectrometry (TDMS) is significantly limited by throughput and dynamic range. We introduce AutoPiMS, a single-ion MS based multiplexed workflow for top-down tandem MS (MS2)
Externí odkaz:
https://doaj.org/article/7587327dde1148caba435a60d10f292c
Autor:
Pang-ning Teng, Waleed Barakat, Sophie M. Tran, Zoe M. Tran, Nicholas W. Bateman, Kelly A. Conrads, Katlin N. Wilson, Julie Oliver, Glenn Gist, Brian L. Hood, Ming Zhou, G. Larry Maxwell, Lorenzo Leggio, Thomas P. Conrads, Mary R. Lee
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Alcohol use disorder (AUD) affects transcriptomic, epigenetic and proteomic expression in several organs, including the brain. There has not been a comprehensive analysis of altered protein abundance focusing on the multiple brain regions th
Externí odkaz:
https://doaj.org/article/0e74ad76aab64490aab99de2055aebe9
Autor:
Nicholas W. Bateman, Tamara Abulez, Anthony R. Soltis, Andrew McPherson, Seongmin Choi, Dale W. Garsed, Ahwan Pandey, Chunqiao Tian, Brian L. Hood, Kelly A. Conrads, Pang-ning Teng, Julie Oliver, Glenn Gist, Dave Mitchell, Tracy J. Litzi, Christopher M. Tarney, Barbara A. Crothers, Paulette Mhawech-Fauceglia, Clifton L. Dalgard, Matthew D. Wilkerson, Mariaelena Pierobon, Emanuel F. Petricoin, Chunhua Yan, Daoud Meerzaman, Clara Bodelon, Nicolas Wentzensen, Jerry S. H. Lee, The APOLLO Research Network, David G. Huntsman, Sohrab Shah, Craig D. Shriver, Neil T. Phippen, Kathleen M. Darcy, David D. L. Bowtell, Thomas P. Conrads, G. Larry Maxwell
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/0fd6d7e0522640fb848fd7d8ca72ab88