Zobrazeno 1 - 10
of 383
pro vyhledávání: '"Thomas P, Loughran"'
Autor:
Mireia Casasampere, Johnson Ung, Alejandro Iñáñez, Carine Dufau, Kazuhito Tsuboi, Josefina Casas, Su-Fern Tan, David J. Feith, Nathalie Andrieu-Abadie, Bruno Segui, Thomas P. Loughran, Jr., José Luis Abad, Gemma Fabrias
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 3, Pp 100520- (2024)
Lipid amidases of therapeutic relevance include acid ceramidase (AC), N-acylethanolamine-hydrolyzing acid amidase, and fatty acid amide hydrolase (FAAH). Although fluorogenic substrates have been developed for the three enzymes and high-throughput me
Externí odkaz:
https://doaj.org/article/cbc54b7eb8e74f508add3ca8fe1b0079
Publikováno v:
eJHaem, Vol 3, Iss 3, Pp 919-923 (2022)
Abstract Large granular lymphocyte leukemia is a rare chronic lymphoproliferative disorder of cytotoxic cells. Other hematological malignancies such as CLL and multiple myeloma have been associated with poor vaccination response and markedly increase
Externí odkaz:
https://doaj.org/article/1ad749cb65a5430880773ac363014c38
Autor:
Johnson Ung, Su-Fern Tan, Todd E. Fox, Jeremy J. P. Shaw, Maansi Taori, Bethany J. Horton, Upendarrao Golla, Arati Sharma, Zdzislaw M. Szulc, Hong-Gang Wang, Charles E. Chalfant, Myles C. Cabot, David F. Claxton, Thomas P. Loughran, David J. Feith
Publikováno v:
Cancers, Vol 15, Iss 24, p 5866 (2023)
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy requiring urgent treatment advancements. Ceramide is a cell-death-promoting signaling lipid that plays a central role in therapy-induced cell death. We previously determined that ac
Externí odkaz:
https://doaj.org/article/2b10d02d3df14a2fa425f31c45b24ad7
Autor:
Katharine B. Moosic, Kusuma Ananth, Felipe Andrade, David J. Feith, Erika Darrah, Thomas P. Loughran
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Large granular lymphocyte (LGL) leukemia, a rare hematologic malignancy, has long been associated with rheumatoid arthritis (RA), and the diseases share numerous common features. This review aims to outline the parallels and comparisons between the d
Externí odkaz:
https://doaj.org/article/fade6aad5da94a9ab11790bf7c5bc3ee
Autor:
Kelsey H. Fisher-Wellman, Miki Kassai, James T. Hagen, P. Darrell Neufer, Mark Kester, Thomas P. Loughran, Charles E. Chalfant, David J. Feith, Su-Fern Tan, Todd E. Fox, Johnson Ung, Gemma Fabrias, Jose’ Luis Abad, Arati Sharma, Upendarrao Golla, David F. Claxton, Jeremy J. P. Shaw, Debajit Bhowmick, Myles C. Cabot
Publikováno v:
Cancers, Vol 15, Iss 6, p 1883 (2023)
Acute myelogenous leukemia (AML), the most prevalent acute and aggressive leukemia diagnosed in adults, often recurs as a difficult-to-treat, chemotherapy-resistant disease. Because chemotherapy resistance is a major obstacle to successful treatment,
Externí odkaz:
https://doaj.org/article/ca6bd77bb8654ba79e7f98395933d8b2
Autor:
Kristine C. Olson, Katharine B. Moosic, Marieke K. Jones, Paige M. K. Larkin, Thomas L. Olson, Mariella F. Toro, Todd E. Fox, David J. Feith, Thomas P. Loughran Jr
Publikováno v:
Cancer Medicine, Vol 9, Iss 18, Pp 6533-6549 (2020)
Abstract Large granular lymphocyte (LGL) leukemia is a rare hematological disorder with expansion of the T‐cell or natural killer (NK) cell lineage. Signal transducer and activator of transcription 3 (STAT3) exhibits somatic activating mutations in
Externí odkaz:
https://doaj.org/article/bd39c179e95b40f8a87836e0597e7555
Autor:
Brian M. Barth, Weiyuan Wang, Paul T. Toran, Todd E. Fox, Charyguly Annageldiyev, Regina M. Ondrasik, Nicole R. Keasey, Timothy J. Brown, Viola G. Devine, Emily C. Sullivan, Andrea L. Cote, Vasiliki Papakotsi, Su-Fern Tan, Sriram S. Shanmugavelandy, Tye G. Deering, David B. Needle, Stephan T. Stern, Junjia Zhu, Jason Liao, Aaron D. Viny, David J. Feith, Ross L. Levine, Hong-Gang Wang, Thomas P. Loughran, Jr, Arati Sharma, Mark Kester, David F. Claxton
Publikováno v:
Blood Advances, Vol 3, Iss 17, Pp 2598-2603 (2019)
Externí odkaz:
https://doaj.org/article/c4625d35b02b4dee8bf8588d9b18b16d
Autor:
Li-Pin Kao, Samy A.F. Morad, Traci S. Davis, Matthew R. MacDougall, Miki Kassai, Noha Abdelmageed, Todd E. Fox, Mark Kester, Thomas P. Loughran, Jr., Jose' L. Abad, Gemma Fabrias, Su-Fern Tan, David J. Feith, David F. Claxton, Sarah Spiegel, Kelsey H. Fisher-Wellman, Myles C. Cabot
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 9, Pp 1590-1602 (2019)
The combination of daunorubicin (dnr) and cytarabine (Ara-C) is a cornerstone of treatment for acute myelogenous leukemia (AML); resistance to these drugs is a major cause of treatment failure. Ceramide, a sphingolipid (SL), plays a critical role in
Externí odkaz:
https://doaj.org/article/fd54fe2e27784a42b78f98d42562f8fa
Autor:
Weiling Li, Lei Yang, Robert S. Harris, Lin Lin, Thomas L. Olson, Cait E. Hamele, David J. Feith, Thomas P. Loughran, Mary Poss
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-12 (2019)
Abstract Background Large granular lymphocyte (LGL) leukemia is an uncommon cancer characterized by sustained clonal proliferation of LGL cells. Antibodies reactive to retroviruses have been documented in the serum of patients with LGL leukemia. Cult
Externí odkaz:
https://doaj.org/article/12f89a5535cd4d0294bfaf00b20929b5
Autor:
Su-Fern Tan, Wendy Dunton, Xin Liu, Todd E. Fox, Samy A.F. Morad, Dhimant Desai, Kenichiro Doi, Mark R. Conaway, Shantu Amin, David F. Claxton, Hong-Gang Wang, Mark Kester, Myles C. Cabot, David J. Feith, Thomas P. Loughran, Jr.
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1078-1086 (2019)
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. More than half of older AML patients fail to respond to cytotoxic chemotherapy, and most responders relapse with drug-resistant disease. Failure to achieve complete remission c
Externí odkaz:
https://doaj.org/article/a185154e7e4d47c99c08cbdef0bdcbba