Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Thomas P, Kohler"'
Autor:
Franziska Jennert, Désirée Schaaf, Roland Nau, Thomas P. Kohler, Sven Hammerschmidt, Darius Häusler, Peter Valentin-Weigand, Jana Seele
Publikováno v:
Journal of Innate Immunity, Vol 16, Iss 1, Pp 248-261 (2024)
Introduction: Streptococcus pneumoniae is the most common cause of bacterial meningitis and meningoencephalitis in humans. The bacterium produces numerous virulence determinants; among them, hydrogen peroxide (H2O2) and pneumolysin (Ply) contribute t
Externí odkaz:
https://doaj.org/article/9bb9f169d9a64e7eb04476f51a53d79d
Autor:
Martín Alcorlo, Mohammed R Abdullah, Leif Steil, Francisco Sotomayor, Laura López-de Oro, Sonia de Castro, Sonsoles Velázquez, Thomas P Kohler, Elisabet Jiménez, Ana Medina, Isabel Usón, Lance E Keller, Jessica L Bradshaw, Larry S McDaniel, María-José Camarasa, Uwe Völker, Sven Hammerschmidt, Juan A Hermoso
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1011883 (2024)
ATP-binding cassette (ABC) transport systems are crucial for bacteria to ensure sufficient uptake of nutrients that are not produced de novo or improve the energy balance. The cell surface of the pathobiont Streptococcus pneumoniae (pneumococcus) is
Externí odkaz:
https://doaj.org/article/b962a379033346788836c4582103dd80
Autor:
Simona Serra, Vittorio Iannotti, Margherita Ferrante, Miguel Tofiño-Vian, Joseph Baxendale, Gilad Silberberg, Thomas P. Kohler, Sven Hammerschmidt, Andrew T. Ulijasz, Federico Iovino
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109583- (2024)
Summary: Bacterial meningitis, frequently caused by Streptococcus pneumoniae (pneumococcus), represents a substantial global health threat leading to long-term neurological disorders. This study focused on the cholesterol-binding toxin pneumolysin (P
Externí odkaz:
https://doaj.org/article/71a669239d3543b5b0d6075aebb164bb
Autor:
Max Brendel, Thomas P. Kohler, Janine V. Neufend, Astrid Puppe, Nicolas Gisch, Sven Hammerschmidt
Publikováno v:
Journal of Innate Immunity, Pp 1-1 (2024)
Introduction: The hydrophilic, polymeric chain of the lipoteichoic acid (LTA) of the Gram-positive pathobiont Streptococcus pneumoniae is covalently linked to the glycosylglycerolipid α-d-glucopyranosyl-(1,3)-diacylglycerol by the LTA ligase TacL, l
Externí odkaz:
https://doaj.org/article/c5dedc7fe60c4d86a88960bed12a9f79
Autor:
Juan José Izquierdo Gonzalez, Md Faruq Hossain, Jolanda Neef, Erin E. Zwack, Chih-Ming Tsai, Dina Raafat, Kevin Fechtner, Luise Herzog, Thomas P. Kohler, Rabea Schlüter, Alexander Reder, Silva Holtfreter, George Y. Liu, Sven Hammerschmidt, Uwe Völker, Victor J. Torres, Jan Maarten van Dijl, Christopher H. Lillig, Barbara M. Bröker, Murty N. Darisipudi
Publikováno v:
mBio, Vol 15, Iss 1 (2024)
ABSTRACTThe iron-regulated surface determinant protein B (IsdB) of Staphylococcus aureus is involved in the acquisition of iron from hemoglobin. Moreover, IsdB elicits an adaptive immune response in mice and humans. Here, we show that IsdB also has i
Externí odkaz:
https://doaj.org/article/40712ab5c48b4f21a5ca40becd530a7c
Autor:
Antje-Maria Lapschies, Etienne Aubry, Thomas P. Kohler, Oliver Goldmann, Sven Hammerschmidt, Andreas Nerlich, Inga Eichhorn, Kira van Vorst, Marcus Fulde
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Streptococcus canis is a zoonotic agent that causes severe invasive diseases in domestic animals and humans, but little is known about its pathogenesis and virulence mechanisms so far. SCM, the M-like protein expressed by S. canis, is considered one
Externí odkaz:
https://doaj.org/article/585a2726bf324fe08f46648d9247db91
Autor:
Fabian Cuypers, Alexander Schäfer, Sebastian B. Skorka, Surabhi Surabhi, Lea A. Tölken, Antje D. Paulikat, Thomas P. Kohler, Saskia A. Otto, Thomas C. Mettenleiter, Sven Hammerschmidt, Ulrike Blohm, Nikolai Siemens
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Seasonal Influenza A virus (IAV) infections can promote dissemination of upper respiratory tract commensals such as Streptococcus pneumoniae to the lower respiratory tract resulting in severe life-threatening pneumonia. Here, we aimed to com
Externí odkaz:
https://doaj.org/article/6eb1f76c002d482fafc69b7d4756b108
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
The pathobiont Streptococcus pneumoniae causes life-threatening diseases, including pneumonia, sepsis, meningitis, or non-invasive infections such as otitis media. Serine proteases are enzymes that have been emerged during evolution as one of the mos
Externí odkaz:
https://doaj.org/article/7c76b253676f4a109b111aa180634d50
Autor:
Andreas Nerlich, Antje-Maria Lapschies, Thomas P. Kohler, Ingrid Cornax, Inga Eichhorn, Oliver Goldmann, Petra Krienke, Simone Bergmann, Victor Nizet, Sven Hammerschmidt, Manfred Rohde, Marcus Fulde
Publikováno v:
Virulence, Vol 10, Iss 1, Pp 194-206 (2019)
Streptococcus canis is a zoonotic agent that causes serious invasive diseases in domestic animals and humans, but knowledge about its pathogenic potential and underlying virulence mechanisms is limited. Here, we report on the ability of certain S. ca
Externí odkaz:
https://doaj.org/article/038a15d212a54647b2549311aef80fa5
Autor:
Murtadha Q. Ali, Thomas P. Kohler, Gerhard Burchhardt, Andreas Wüst, Nadin Henck, Robert Bolsmann, Franziska Voß, Sven Hammerschmidt
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2021)
Streptococcus pneumoniae has evolved versatile strategies to colonize the nasopharynx of humans. Colonization is facilitated by direct interactions with host cell receptors or via binding to components of the extracellular matrix. In addition, pneumo
Externí odkaz:
https://doaj.org/article/867fd157c7a846ddb452da20cfc30f6f