Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Thomas P, Keeley"'
Autor:
Karen C. Heathcote, Thomas P. Keeley, Matti Myllykoski, Malin Lundekvam, Nina McTiernan, Salma Akter, Norma Masson, Peter J. Ratcliffe, Thomas Arnesen, Emily Flashman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Oxygen homeostasis is maintained in plants and animals by O2-sensing enzymes initiating adaptive responses to low O2 (hypoxia). Recently, the O2-sensitive enzyme ADO was shown to initiate degradation of target proteins RGS4/5 and IL32 via th
Externí odkaz:
https://doaj.org/article/b131b08f851f4fecb899153290804823
Autor:
Gulsah Sevimli, Matthew J. Smith, Tuba Akgul Caglar, Şükriye Bilir, Melike Secilmis, Hamza Y. Altun, Esra N. Yigit, Fan Yang, Thomas P. Keeley, Roland Malli, Gürkan Öztürk, Giovanni E. Mann, Emrah Eroglu
Publikováno v:
Redox Biology, Vol 54, Iss , Pp 102364- (2022)
Externí odkaz:
https://doaj.org/article/9dcb7807763e4afd81fc61eb67d74876
Autor:
Gulsah Sevimli, Matthew J. Smith, Tuba Akgul Caglar, Şükriye Bilir, Melike Secilmis, Hamza Y. Altun, Esra N. Yigit, Fan Yang, Thomas P. Keeley, Roland Malli, Gürkan Öztürk, Giovanni E. Mann, Emrah Eroglu
Publikováno v:
Redox Biology, Vol 53, Iss , Pp 102319- (2022)
Iron is an essential metal for cellular metabolism and signaling, but it has adverse effects in excess. The physiological consequences of iron deficiency are well established, yet the relationship between iron supplementation and pericellular oxygen
Externí odkaz:
https://doaj.org/article/ae43eb1dd385499690bf5af27e5b1a1b
Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells
Autor:
Peter A.C. Wing, Thomas P. Keeley, Xiaodong Zhuang, Jeffrey Y. Lee, Maria Prange-Barczynska, Senko Tsukuda, Sophie B. Morgan, Adam C. Harding, Isobel L.A. Argles, Samvid Kurlekar, Marko Noerenberg, Craig P. Thompson, Kuan-Ying A. Huang, Peter Balfe, Koichi Watashi, Alfredo Castello, Timothy S.C. Hinks, William James, Peter J. Ratcliffe, Ilan Davis, Emma J. Hodson, Tammie Bishop, Jane A. McKeating
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109020- (2021)
Summary: COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment, and one important factor to consider is oxygen tension,
Externí odkaz:
https://doaj.org/article/0e81e8390d8b4bff8a888f023b7b0038
Autor:
Gabriela Warpsinski, Matthew J. Smith, Salil Srivastava, Thomas P. Keeley, Richard C.M. Siow, Paul A. Fraser, Giovanni E. Mann
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101708- (2020)
Ischemic stroke is associated with a surge in reactive oxygen species generation during reperfusion. The narrow therapeutic window for the delivery of intravenous thrombolysis and endovascular thrombectomy limits therapeutic options for patients. Thu
Externí odkaz:
https://doaj.org/article/047eb14f816f4bad9543c59bb2faf295
Autor:
Samantha Cruz Rivera, Derek G Kyte, Olalekan Lee Aiyegbusi, Thomas J Keeley, Melanie J Calvert
Publikováno v:
PLoS Medicine, Vol 14, Iss 8, p e1002370 (2017)
BackgroundIncreasingly, researchers need to demonstrate the impact of their research to their sponsors, funders, and fellow academics. However, the most appropriate way of measuring the impact of healthcare research is subject to debate. We aimed to
Externí odkaz:
https://doaj.org/article/a0ccf718f466448fbb2beaf0fc7fdfb4
Autor:
Ilan Davis, Peter J. Ratcliffe, Alfredo Castello, William James, Jeffrey Y. Lee, Maria Prange-Barczynska, Marko Noerenberg, Jane A. McKeating, Craig Thompson, Senko Tsukuda, Koichi Watashi, Isobel L.A. Argles, Thomas P. Keeley, Sophie B. Morgan, Peter A C Wing, Samvid Kurlekar, Kuan-Ying A. Huang, Xiaodong Zhuang, Timothy S. C. Hinks, Tammie Bishop, Peter Balfe, Emma J. Hodson, Adam Harding
Publikováno v:
Cell Reports
Cell Reports, Vol 35, Iss 3, Pp 109020-(2021)
Cell Reports, Vol 35, Iss 3, Pp 109020-(2021)
COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment and one important factor to consider is oxygen tension, where hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8e53769facfdeba33434aaf01a539d
http://europepmc.org/articles/PMC8020087
http://europepmc.org/articles/PMC8020087
Autor:
Giovanni E. Mann, Richard C.M. Siow, Matthew J. Smith, Paul A. Fraser, Salil Srivastava, Thomas P. Keeley, Gabriela Warpsinski
Publikováno v:
Redox Biology, Vol 37, Iss, Pp 101708-(2020)
Redox Biology
Redox Biology
Ischemic stroke is associated with a surge in reactive oxygen species generation during reperfusion. The narrow therapeutic window for the delivery of intravenous thrombolysis and endovascular thrombectomy limits therapeutic options for patients. Thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3c37b6ad6b0bcc84f7e1b64ef909a5
http://www.sciencedirect.com/science/article/pii/S2213231720309137
http://www.sciencedirect.com/science/article/pii/S2213231720309137
Hypoxic and Pharmacological Activation of HIF Inhibits SARS-CoV-2 Infection of Lung Epithelial Cells
Autor:
Maria Prange-Barczynska, Senko Tsukuda, William James, Tammie Bishop, Thomas P. Keeley, Koichi Watashi, Xiaodong Zhuang, Ilan Davies, Jane A. McKeating, Peter A C Wing, Emma J. Hodson, Peter J. Ratcliffe, Isobel L.A. Argles, Peter Balfe, Kuan-Ying A. Huang, Samvid Kurlekar, Timothy S. C. Hinks, Sophie B. Morgan, Alfredo Castello Palomares, Craig Thompson, Jeffrey Y. Lee, Marko Noerenberg
Publikováno v:
SSRN Electronic Journal.
COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more than 1 million fatalities to date. Understanding how host factors modify the viral life cycle could inform susceptibility to viral infection and the design of ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e724e4b63caea6df3aaa7e460fad81
https://doi.org/10.2139/ssrn.3720002
https://doi.org/10.2139/ssrn.3720002