Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Thomas P, Brent"'
Publikováno v:
Molecular Cancer Therapeutics. 4:61-69
Transcriptional silencing of the DNA repair gene, O6-methylguanine-DNA methyltransferase (MGMT) in a proportion of transformed cell lines is associated with methylated CpG hotspots in the MGMT 5′ flank. The goal of the study was to evaluate the mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::074e7dbfd2cf96aa3c5e56ae41678187
https://doi.org/10.1158/1535-7163.61.4.1
https://doi.org/10.1158/1535-7163.61.4.1
Autor:
Chunlai Zuo, Lingbao Ai, Pam Ratliff, James Y. Suen, Ehab Hanna, Thomas P. Brent, Chun-Yang Fan
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 13:967-975
Background: Alkylating N-nitroso compounds can interact directly with DNA, forming O6-alkylguanine, a DNA adduct proved to be mutagenic and carcinogenic if not sufficiently repaired. A specific DNA repair enzyme, O6-methylguanine-DNA methyltransferas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a99459fbf6e8755c50236f8d81eafb1
https://doi.org/10.1158/1055-9965.967.13.6
https://doi.org/10.1158/1055-9965.967.13.6
Autor:
Thomas P. Brent, Krishnamurthy Shyam, Raymond P. Baumann, J. S. Remack, Philip G. Penketh, Alan C. Sartorelli
Publikováno v:
Cancer Chemotherapy and Pharmacology. 53:279-287
To investigate the interaction of the electrophilic species generated by the decomposition of the antineoplastic prodrug 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M) on the ability of O(6)-alkylguanine-DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36f9add49e1a6ac3751e9e894d08c7e
https://doi.org/10.1007/s00280-003-0740-7
https://doi.org/10.1007/s00280-003-0740-7
Autor:
Thomas P. Brent, Derek A. Persons, Hideki Hanawa, Nobukuni Sawai, Arthur W. Nienhuis, Phillip W. Hargrove, Esther R. Allay, Brian P. Sorrentino
Publikováno v:
Blood. 102:506-513
Successful gene therapy of β-thalassemia will require replacement of the abnormal erythroid compartment with erythropoiesis derived from genetically corrected, autologous hematopoietic stem cells (HSCs). However, currently attainable gene transfer e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9297d9f2cd8498cd60f2bac3c354831
https://doi.org/10.1182/blood-2003-03-0677
https://doi.org/10.1182/blood-2003-03-0677
Autor:
Samuel A. Wells, Klaus K.-F. Herfarth, Joanna S. Remack, Paul J. Goodfellow, Thomas P. Brent, Ira J. Kodner, Rebecca P. Danam
Publikováno v:
Molecular Carcinogenesis. 24:90-98
The enzyme O6-methylguanine-DNA methyltransferase (MGMT) protects cells from the cytotoxic and mutagenic effects of alkylating agents. Approximately 20% of tumor cell lines lack MGMT activity and are highly sensitive to alkylating agents. In establis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ee59dc66406dead00bcf8bce1b1ff90
https://doi.org/10.1002/(sici)1098-2744(199902)24:2<90::aid-mc3>3.0.co
https://doi.org/10.1002/(sici)1098-2744(199902)24:2<90::aid-mc3>3.0.co
Publikováno v:
Molecular Carcinogenesis. 24:85-89
O6-Methylguanine-DNA methyltransferase (MGMT) is a major determinant of susceptibility to methylating carcinogens and of tumor resistance to anticancer methylating and chloroethylating drugs. The silencing of MGMT expression that occurs in 20–30% o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::424b44abb82e62c361ff0afc55de879c
https://doi.org/10.1002/(sici)1098-2744(199902)24:2<85::aid-mc2>3.0.co
https://doi.org/10.1002/(sici)1098-2744(199902)24:2<85::aid-mc2>3.0.co
Autor:
Anthony E. Pegg, Cynthia Kilborn, Robert F. Struck, Darell D. Bigner, Nancy S. Bullock, M. Eileen Dolan, Susan M. Ludeman, Paul Modrich, Henry S. Friedman, O. Michael Colvin, Robert C. Moschel, Stewart P. Johnson, Thomas P. Brent, Natalia A. Loktionova, Steve Keir, Qing Dong
Publikováno v:
Cancer Chemotherapy and Pharmacology. 43:80-85
Purpose: The human medulloblastoma cell line D283 Med (4-HCR), a line resistant to 4-hydroperoxycyclophosphamide (4-HC), displays enhanced␣repair of DNA interstrand crosslinks induced by phosphoramide mustard. D283 Med (4-HCR) cells are cross-resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ea8d5697f3ef1c4c7b5de46f88aa36
https://doi.org/10.1007/s002800050866
https://doi.org/10.1007/s002800050866
Publikováno v:
Proceedings of the National Academy of Sciences. 94:4348-4353
O 6 -Methylguanine-DNA methyltransferase (MGMT), an enzyme that repairs adducts at O 6 of guanine in DNA, is a major determinant of susceptibility to simple methylating carcinogens or of tumor response to anticancer chloroethylating drugs. To investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17ce05d5ab73d497fa7a5f890ed982c
https://doi.org/10.1073/pnas.94.9.4348
https://doi.org/10.1073/pnas.94.9.4348
Publikováno v:
British Journal of Cancer
Methionine (MET)-dependent cell lines require MET to proliferate, and homocysteine (HCY) does not act as a substitute for this requirement. From six O6-methylguanine-DNA methyltransferase (MGMT)-efficient (mer+) cell lines tested, two medulloblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7eb496a425293df85b3abcf359e5c0
http://europepmc.org/articles/PMC2063394
http://europepmc.org/articles/PMC2063394
Publikováno v:
Blood. 88:2298-2305
Fanconi anemia (FA) cells are hypersensitive to cytotoxicity, cell cycle arrest, and chromosomal aberrations induced by DNA cross-linking agents, such as mitomycin C (MMC) and nitrogen mustard (HN2). Although MMC hypersensitivity is complemented in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5f85065120f3237849bb0385e2d525d
https://doi.org/10.1182/blood.v88.6.2298.bloodjournal8862298
https://doi.org/10.1182/blood.v88.6.2298.bloodjournal8862298