Unlocking the Mechanisms of Cutaneous Adverse Drug Reactions: Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway by EGFR Inhibitors Triggers Keratinocyte Differentiation and Polarization of Epidermal Immune Responses

Autor: Thomas Ondet, Pierre-François Roux, Mario Monshouwer, Georgios N. Stamatas

Publikováno v: JID Innovations, Vol 1, Iss 2, Pp 100009- (2021)

EGFR inhibitors used in oncology therapy modify the keratinocyte differentiation processes, impairing proper skin barrier formation and leading to cutaneous adverse drug reactions. To uncover the molecular signatures associated with cutaneous adverse

Externí odkaz: https://doaj.org/article/19c458bef6b84fc38a63ef0db8e0d9b8

Unlocking the Mechanisms of Cutaneous Adverse Drug Reactions: Activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway by EGFR Inhibitors Triggers Keratinocyte Differentiation and Polarization of Epidermal Immune Responses

Autor: Georgios N. Stamatas, Thomas Ondet, Mario Monshouwer, Pierre-François Roux

Publikováno v: JID Innovations
JID Innovations, Vol 1, Iss 2, Pp 100009-(2021)

EGFR inhibitors used in oncology therapy modify the keratinocyte differentiation processes, impairing proper skin barrier formation and leading to cutaneous adverse drug reactions. To uncover the molecular signatures associated with cutaneous adverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86691b3a1b900b415da33bfa5e7871c9
https://pubmed.ncbi.nlm.nih.gov/34909713

26634 Insights into the mechanisms of EGFRi-induced cutaneous adverse drug reactions from functional phospho-proteomic and transcriptomic data

Autor: Mario Monshouwer, Georgios N. Stamatas, Thomas Ondet

Publikováno v: Journal of the American Academy of Dermatology. 85:AB22

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ba2a5798556fb3079cb7ec7f01363ae
https://doi.org/10.1016/j.jaad.2021.06.115

The release of pro-inflammatory cytokines is mediated via mitogen-activated protein kinases rather than by the inflammasome signalling pathway in keratinocytes

Autor: Béatrice Muscatelli-Groux, Sacha Robert, Jean Alexis Grimaud, Cédric Coulouarn, Thomas Ondet, Thomas Gicquel, Vincent Lagente, Aude Bodin

Publikováno v: Clinical and Experimental Pharmacology and Physiology
Clinical and Experimental Pharmacology and Physiology, Wiley, 2017, 44 (7), pp.827-838. ⟨10.1111/1440-1681.12765⟩
Clinical and Experimental Pharmacology and Physiology, 2017, 44 (7), pp.827-838. ⟨10.1111/1440-1681.12765⟩

International audience; Toll-like receptors (TLRs) are expressed in the skin and airway epithelial tissues, which are the most important sites of host-pathogen interactions. TLRs recognize the 3-D structures of pathogen-associated molecules and are t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32036b757854e17741917b1a14663b1
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01560560/document