Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Thomas O Millner"'
Autor:
Anna Lerner, Kieran Palmer, Tom Campion, Thomas O Millner, Emily Scott, Cressida Lorimer, Dimitrios Paraskevopoulos, Grainne McKenna, Silvia Marino, Rachel Lewis, Nick Plowman
Publikováno v:
Clinical Medicine, Vol 24, Iss 5, Pp 100240- (2024)
Primary brain tumours are rare but carry a significant morbidity and mortality burden. Malignant gliomas are the most common subtype and their incidence is increasing within our ageing population. The diagnosis and treatment of gliomas involves subst
Externí odkaz:
https://doaj.org/article/496e6adea1364cd78ce24f372b35dc1d
Autor:
Claire Vinel, Gabriel Rosser, Loredana Guglielmi, Myrianni Constantinou, Nicola Pomella, Xinyu Zhang, James R. Boot, Tania A. Jones, Thomas O. Millner, Anaelle A. Dumas, Vardhman Rakyan, Jeremy Rees, Jamie L. Thompson, Juho Vuononvirta, Suchita Nadkarni, Tedani El Assan, Natasha Aley, Yung-Yao Lin, Pentao Liu, Sven Nelander, Denise Sheer, Catherine L. R. Merry, Federica Marelli-Berg, Sebastian Brandner, Silvia Marino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The identification of patient-specific disease mechanisms and druggable targets is crucial for precision medicine in glioblastoma. Here, the authors show that comparing patients-matched glioma-initiating cells with neural stem cells enables the disco
Externí odkaz:
https://doaj.org/article/eef727b592d24a7697303fa96e18e608
Autor:
James R. Boot, Denise Sheer, Vardhman K. Rakyan, Catherine L.R. Merry, Claire Vinel, Sebastian Brandner, Sven Nelander, Yung-Yao Lin, Suchita Nadkarni, Tedani El Assan, Juho Vuononvirta, Thomas O Millner, Federica M. Marelli-Berg, Myrianni Constantinou, Loredana Guglielmi, Jamie L. Thompson, Xinyu Zhang, Gabriel Rosser, Tania A. Jones, Pentao Liu, Nicola Pomella, Anaelle A. Dumas, Jeremy Rees, Natasha Aley, Silvia Marino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications
Nature Communications
Epigenetic mechanisms which play an essential role in normal developmental processes, such as self-renewal and fate specification of neural stem cells (NSC) are also responsible for some of the changes in the glioblastoma (GBM) genome. Here we develo
Autor:
Loredana Guglielmi, Barbara Ricci, Nicola Pomella, Erica Cognolato, Michael R. Barnes, Silvia Marino, Sara Badodi, Dario Ceric, Xinyu Zhang, Carolina Gemma, Ying Zhang, Sebastian Brandner, Thomas O Millner
Publikováno v:
Oncogene
Glioblastoma (GBM) is the most common and most aggressive intrinsic brain tumour in adults. Integrated transcriptomic and epigenomic analyses of glioblastoma initiating cells (GIC) in a mouse model uncovered a novel epigenetic regulation of EfnA5. In
Autor:
Thomas O Millner, Eleni Maniati, Anaelle A. Dumas, Maria Victoria Niklison-Chirou, Jun Wang, Nicola Pomella, Verónica Freire-Benéitez, Pedro R. Cutillas, Vinothini Rajeeve, Silvia Marino
Publikováno v:
NAR Cancer
Glioblastoma (GBM) is the most common and aggressive intrinsic brain tumour in adults. Epigenetic mechanisms controlling normal brain development are often dysregulated in GBM. Among these, BMI1, a structural component of the Polycomb Repressive Comp
Autor:
Eleni Maniati, Jun Wang, Nicola Pomella, Maria Victoria Niklison-Chirou, Verónica Freire-Benéitez, Thomas O Millner, Silvia Marino, Vinothini Rajeeve, Anaelle A. Dumas, Pedro R. Cutillas
Publikováno v:
NAR Cancer
Glioblastoma (GBM) is the most common and aggressive intrinsic brain tumour in adults. Epigenetic mechanisms controlling normal brain development are often dysregulated in GBM. Among these, BMI1, a structural component of the Polycomb Repressive Comp
Autor:
Natasha Aley, Anantha Marisetty, Loredana Guglielmi, Sebastian Brandner, Johanna A. Joyce, Denise Sheer, Robert L. Bowman, Nicola Pomella, Jeremy Rees, Silvia Marino, Jun Wei, Amy B. Heimberger, Anaelle A. Dumas, Gabriel Rosser, Thomas O Millner, Claire Vinel
Publikováno v:
The EMBO Journal
The EMBO journal, vol. 39, no. 15, pp. e103790
The EMBO journal, vol. 39, no. 15, pp. e103790
Tumour‐associated microglia/macrophages (TAM) are the most numerous non‐neoplastic populations in the tumour microenvironment in glioblastoma multiforme (GBM), the most common malignant brain tumour in adulthood. The mTOR pathway, an important re
Publikováno v:
Neuro Oncol
Introduction The epigenetic regulator Bmi1 is essential for the self-renewal of neural stem cells (NSC), and highly expressed in glioblastoma (GBM) stem/initiating cells (GIC), where knockdown significantly reduces tumour growth in xenograft models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088e06dad71d42547f888f20800a2215
https://europepmc.org/articles/PMC6789976/
https://europepmc.org/articles/PMC6789976/
Autor:
Giorgia Trevisan, C. Blake Gilks, Lynn Hirschowitz, Asma Faruqi, Thomas O Millner, Reena Merard, Steffen Böhm, Sharanpal Jeetle, Jacqueline McDermott, Jo Vella, Sarah Lam Shang Leen, Ian Said, Naveena Singh, Joanne Beasley, Peter Ellery, Raji Ganesan, W. Glenn McCluggage
Publikováno v:
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 36(2)
A 3-tier histopathologic scoring system, the chemotherapy response score (CRS), was previously devised for reporting the histologic response to neoadjuvant chemotherapy in interval debulking surgery specimens of stage IIIc/IV tuboovarian high-grade s