Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Thomas O, Ronson"'
Publikováno v:
The Journal of Organic Chemistry. 87:2111-2119
An early synthetic step in the synthesis of adavosertib, AZD1775, is the SNAr reaction between 4-fluoronitrobenzene and 1-methylpiperazine in acetonitrile. A simple kinetics-based design of four reaction profiling experiments was used to investigate
Autor:
Lucie Miller-Potucka, Gall Malcolm Allan Young, Ian W. Ashworth, Andrew J. Robbins, Oliver T. Ring, Martin F. Jones, Barry R. Hayter, Rosemary A. Wordsworth, Adam J. Leahy, Lyn Powell, Phillip A. Inglesby, Alex L. Lamacraft, Okky Dwichandra Putra, Janette H. Cherryman, Thomas O. Ronson, Peter R. Hamilton, Simone Tomasi, Lauren R. Agnew, David C. McKinney
Publikováno v:
Organic Process Research & Development. 26:936-948
Autor:
James Morrison, Rachel H. Munday, Thomas O. Ronson, Matthew R. Tatton, Hucheng Zhao, Calum Cook, Daniël de Bruin, Kevin William Leslie, Kuangchu Dai, David Buttar, Catalina Ferrer, James Douglas
Publikováno v:
The Journal of Organic Chemistry. 87:2075-2086
Route design and proof of concept synthesis was conducted on a synthetically challenging atropisomeric KRASG12C inhibitor to support clinical API manufacture. Improvements to the synthesis of a chiral piperazine fragment gave reduced step count and s
Autor:
Alasdair K. Cooper, Megan Greaves, Alan R. Kennedy, William Donohoe, Thomas O. Ronson, David J. Nelson, Paul M. Burton
Publikováno v:
Chemical Science
A nickel/dppf catalyst system was found to successfully achieve the Suzuki–Miyaura cross-coupling reactions of 3- and 4-chloropyridine and of 6-chloroquinoline but not of 2-chloropyridine or of other α-halo-N-heterocycles. Further investigations r
Publikováno v:
Organometallics
[Image: see text] The reactions of dppf-nickel(0) with alkyl halides proceed via three-coordinate nickel(0) intermediates of the form [Ni(dppf)(L)]. The effects of the identity of the added ligand (L) on catalyst speciation and the rates of reactions
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1159-1165 (2014)
Two mild and efficient strategies have been developed for the O-functionalisation of 4-hydroxy-6-alkyl-2-pyrones, by using them as nucleophilic partners in oxa-Michael additions and the Mitsunobu reaction. The reactions proceed in moderate to excelle
Externí odkaz:
https://doaj.org/article/6ce990d8e43840378c8143dbef9b01f0
Autor:
Stephen Sproules, Megan Greaves, David J. Nelson, Guy C. Lloyd-Jones, Feliu Maseras, Thomas O. Ronson
Publikováno v:
Greaves, M E, Ronson, T O, Lloyd-jones, G C, Maseras, F, Sproules, S & Nelson, D J 2020, ' Unexpected Nickel Complex Speciation Unlocks Alternative Pathways for the Reactions of Alkyl Halides with dppf-Nickel(0) ', ACS Catalysis, vol. 10, no. 18, pp. 10717-10725 . https://doi.org/10.1021/acscatal.0c02514
ACS Catalysis
ACS Catalysis
The mechanism of the reactions between dppf-Ni0 complexes and alkyl halides has been investigated using kinetic and mechanistic experiments and DFT calculations. The active species is [Ni(κ2-dppf)(κ1-dppf)], which undergoes a halide abstraction rea
Publikováno v:
The Journal of organic chemistry. 87(4)
An early synthetic step in the synthesis of adavosertib, AZD1775, is the S
The reactions of dppf-nickel(0) with alkyl halides proceed via three-coordinate nickel(0) intermediates of the form [Ni(dppf)(L)]. The effect of the identity of the added ligand (L) on catalyst speciation and the rates of reactions of [Ni(COD)(dppf)]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf79f1549fcfc33c1c7d251dbcf68bf
https://doi.org/10.26434/chemrxiv.14535315.v1
https://doi.org/10.26434/chemrxiv.14535315.v1
Autor:
Bethany A. Jackson, Matthew Charles Evans, Gareth AstraZeneca R D Charnwood Ensor, Adam Clarke, Chris D. Parsons, Mairi M. Littleson, Mark Dow, Danny H. Legg, Thomas O. Ronson, Adam Herring, David J. Klauber, Štefan Moravčík, Rebecca E. Meadows, Andrew D. Campbell, Jackson Lucinda Victoria, Kevin William Leslie, Staffan Karlsson
Publikováno v:
Organic Process Research & Development. 23:1407-1419
The AstraZeneca approach to synthetic Route Design is exemplified through our AZD4635 chemical development program. The identification of possible new route concepts is presented, as well as their ...