Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Thomas O, Joos"'
Autor:
Wael Naboulsi, Hannes Planatscher, Felix F. Schmidt, Andreas Steinhilber, Thomas O. Joos, Adeyemi O. Adedeji, James Eric McDuffie, Oliver Pötz
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 180-197 (2024)
Drug-induced kidney injury (DIKI) is a cause of drug development failure. Dogs represent a common non-rodent animal model in pre-clinical safety studies; however, biomarker assays for detecting nephrotoxicity in dogs are limited. To identify novel pr
Externí odkaz:
https://doaj.org/article/0d5cf4ccd8aa424fa54114b5192b6cf7
Autor:
Stefanie Lerche, Milan Zimmermann, Benjamin Roeben, Isabel Wurster, Franca Laura Fries, Christian Deuschle, Katharina Waniek, Ingolf Lachmann, Meike Jakobi, Thomas O. Joos, Thomas Knorpp, Nicole Schneiderhan-Marra, Kathrin Brockmann
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Inflammation modifies the incidence and progression of Parkinson’s disease (PD). By using 30 inflammatory markers in CSF in 498 people with PD and 67 people with dementia with Lewy bodies (DLB) we show that: (1) levels of ICAM-1, Interleuk
Externí odkaz:
https://doaj.org/article/10293bd7e8d6473fbc25141674fa7271
Autor:
Matthias Becker, Monika Strengert, Daniel Junker, Philipp D. Kaiser, Tobias Kerrinnes, Bjoern Traenkle, Heiko Dinter, Julia Häring, Stéphane Ghozzi, Anne Zeck, Frank Weise, Andreas Peter, Sebastian Hörber, Simon Fink, Felix Ruoff, Alex Dulovic, Tamam Bakchoul, Armin Baillot, Stefan Lohse, Markus Cornberg, Thomas Illig, Jens Gottlieb, Sigrun Smola, André Karch, Klaus Berger, Hans-Georg Rammensee, Katja Schenke-Layland, Annika Nelde, Melanie Märklin, Jonas S. Heitmann, Juliane S. Walz, Markus Templin, Thomas O. Joos, Ulrich Rothbauer, Gérard Krause, Nicole Schneiderhan-Marra
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Serology is an important way to monitor SARS-CoV-2 infection in the population and support vaccine development. Here the authors develop a multiplex immunoassay including spike and nucleocapsid proteins of SARS-CoV-2 and the endemic human coronavirus
Externí odkaz:
https://doaj.org/article/873a2271e3d141e88ecbd175b0df6297
Autor:
Stefanie Lerche, Milan Zimmermann, Isabel Wurster, Benjamin Roeben, Franca Laura Fries, Christian Deuschle, Katharina Waniek, Ingolf Lachmann, Thomas Gasser, Meike Jakobi, Thomas O. Joos, Nicole Schneiderhan-Marra, Kathrin Brockmann
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundAn involvement of the central-nervous and peripheral, innate and adaptive immune system in the pathogenesis of Parkinson's disease (PD) is nowadays well established.ObjectivesWe face several open questions in preparation of clinical trials
Externí odkaz:
https://doaj.org/article/a03fb7f37be348319ac70ec322483f47
Autor:
Michael Ghosh, Hanna Hartmann, Meike Jakobi, Léo März, Leon Bichmann, Lena K. Freudenmann, Lena Mühlenbruch, Sören Segan, Hans-Georg Rammensee, Nicole Schneiderhan-Marra, Christopher Shipp, Stefan Stevanović, Thomas O. Joos
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Biomaterials play an increasing role in clinical applications and regenerative medicine. A perfectly designed biomaterial should restore the function of damaged tissue without triggering an undesirable immune response, initiate self-regeneration of t
Externí odkaz:
https://doaj.org/article/c3f137c9ac3f4f089fbf174528a3f604
Autor:
Rezzak Yilmaz, Antonio P. Strafella, Alice Bernard, Claudia Schulte, Lieneke van den Heuvel, Nicole Schneiderhan-Marra, Thomas Knorpp, Thomas O. Joos, Frank Leypoldt, Johanna Geritz, Clint Hansen, Sebastian Heinzel, Anja Apel, Thomas Gasser, Anthony E. Lang, Daniela Berg, Walter Maetzler, Connie Marras
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Background: Blood levels of immune markers have been proposed to discriminate patients with Parkinson's disease (PD) from controls. However, differences between clinical PD subgroups regarding these markers still need to be identified.Objective: To i
Externí odkaz:
https://doaj.org/article/c5dae86bd09f43129034056a92a4179b
Autor:
Fridolin Treindl, Benjamin Ruprecht, Yvonne Beiter, Silke Schultz, Anette Döttinger, Annette Staebler, Thomas O. Joos, Simon Kling, Oliver Poetz, Tanja Fehm, Hans Neubauer, Bernhard Kuster, Markus F. Templin
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Dissecting cellular signalling requires the analysis of large numbers of proteins. Here the authors describe DigiWest, a high-throughput protein detection method that combines the concept of western and widely-used bead array systems that allows rapi
Externí odkaz:
https://doaj.org/article/cd4dedf92230459d95726b4e2994b33f
Autor:
Oliver Poetz, Thomas O. Joos, Andreas E. Steinhilber, Paula Katavolos, Cornelia Sommersdorf, Hannes Planatscher, Montserrat Carrasco-Triguero, Viktoria Anselm
Publikováno v:
Journal of Proteome Research. 20:4985-4994
Macrophage colony stimulating factor 1 receptor (MCSF1R), osteopontin (OPN), high-mobility group protein B1 (HMGB1), glutamate dehydrogenase (GLDH), keratin 18 (K18), and caspase-cleaved keratin 18 (ccK18) are considered promising mechanistic biomark
Autor:
Ulrich Rothbauer, Anne Zeck, Cornelia Sommersdorf, Markus F. Templin, Oliver Poetz, Sandra Maier, Thomas O. Joos, Ulrich Kratzer, Teresa R Wagner
Publikováno v:
Bioconjugate Chemistry. 32:1960-1965
N-Hydroxysuccinimide esters of small molecules are widely used to modify biomolecules such as antibodies or proteins. Primary amine groups preferably react with the ester to form covalent amide bonds. Currently, protocols strongly recommend replacing
Autor:
Bjoern Traenkle, Annika Nelde, Gérard Krause, Ulrich Rothbauer, Natalia Ruetalo, Aaron Stahl, Frank Weise, Michael Schindler, Andreas Peter, Matthias Becker, Armin Baillot, Sebastian Hörber, Daniel Junker, Thomas O. Joos, Katja Schenke-Layland, Simon Fink, Philipp D. Kaiser, Nicole Schneiderhan-Marra, Markus F. Templin, Juliane S. Walz, Felix Ruoff
Publikováno v:
ACS infectious Diseases
ACS Infectious Diseases
ACS Infectious Diseases
The presence of antibodies against endemic coronaviruses has been linked to disease severity after SARS-CoV-2 infection. Assays capable of concomitantly detecting antibodies against endemic coronaviridae such as OC43, 229E, NL63, and SARS-CoV-2 may h