Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Thomas Niezold"'
Autor:
Vladimir Temchura, Svetlana Kalinin, Ghulam Nabi, Bettina Tippler, Thomas Niezold, Klaus Überla
Publikováno v:
Viruses, Vol 6, Iss 8, Pp 3334-3347 (2014)
A major advantage of virus-like particle (VLP) vaccines against HIV is their structural identity to wild-type viruses, ensuring that antigen-specific B-cells encounter the envelope protein in its natural conformation. For the induction of affinity-ma
Externí odkaz:
https://doaj.org/article/c772cc093c6b4b40b18692f832d3cfeb
Autor:
Viktoria Stab, Sandra Nitsche, Thomas Niezold, Michael Storcksdieck Genannt Bonsmann, Andrea Wiechers, Bettina Tippler, Drew Hannaman, Christina Ehrhardt, Klaus Uberla, Thomas Grunwald, Matthias Tenbusch
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72217 (2013)
The Respiratory Syncytial Virus (RSV) and Influenza A Virus (IAV) are both two major causative agents of severe respiratory tract infections in humans leading to hospitalization and thousands of deaths each year. In this study, we evaluated the immun
Externí odkaz:
https://doaj.org/article/38e7064074b84ad99e8ffe605715cc82
Autor:
M. Anthony Moody, Aaron G. Schmidt, John Misasi, Wing Pui Kong, Bo Wang, Farida Laboune, John R. Mascola, George Georgiou, Chang W. Choi, Alberto Cagigi, Eun Sung Yang, Nancy J. Sullivan, Morgan R. Timm, Kwanyee Leung, Daniel C. Douek, Rui Kong, Julie E. Ledgerwood, Ahmed S. Fahad, Barney S. Graham, David R. Ambrozak, Jonathan R. McDaniel, Elise G. Viox, Erica Normandin, Brandon J. DeKosky, Jiwon Lee, Thomas Niezold, George Delidakis, Amy R. Henry, Aurélie Ploquin, Mark Connors, Leigh Kendra Elizabeth, Andrew D. Ellington, William N. Voss
Publikováno v:
Nature biotechnology
We present a technology to screen millions of B cells for natively paired human antibody repertoires. Libraries of natively paired, variable region heavy and light (VH:VL) amplicons are expressed in a yeast display platform that is optimized for huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e453467d579af11fa5115b52d31bde05
http://europepmc.org/articles/PMC5801115
http://europepmc.org/articles/PMC5801115
Autor:
Thomas Niezold, Nancy J. Sullivan, Yan Zhou, Aurélie Ploquin, John Misasi, Yaroslav Tsybovsky, Alberto Cagigi
Publikováno v:
The Journal of infectious diseases. 218(suppl_5)
The membrane-proximal external regions (MPER) of the human immunodeficiency virus envelope glycoprotein (GP) generate broadly reactive antibody responses and are the focus of vaccine development efforts. The conservation of amino acids within filovir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cbd4825d5300c04bc048ae198a5f96
https://pubmed.ncbi.nlm.nih.gov/30137549
https://pubmed.ncbi.nlm.nih.gov/30137549
Autor:
Franco Pissani, Nana Yaw Osei-Owusu, Katrin Ehrhardt, Eric P. Brown, Hartmut Hengel, Hendrik Streeck, Vladimir Temchura, Ghulam Nabi, Klaus Überla, Drew Hannaman, Michael Storcksdieck genannt Bonsmann, Matthias Tenbusch, Margaret E. Ackerman, Thomas Niezold
Publikováno v:
The Journal of Immunology. 195:4861-4872
The importance of Fc-dependent effector functions of Abs induced by vaccination is increasingly recognized. However, vaccination of mice against HIV envelope (Env) induced a skewed Th cell response leading to Env-specific Abs with reduced effector fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5b4300f21e5cdcc276c17263b2ecb3
https://doi.org/10.4049/jimmunol.1501377
https://doi.org/10.4049/jimmunol.1501377
Autor:
Brandon J. DeKosky, Bo Wang, Morgan Timm, Jiwon Lee, Erica Normandin, John Misasi, Rui Kong, Jonathan R. McDaniel, George Delidakis, Kendra E. Leigh, Thomas Niezold, Aurélie Ploquin, Elise G. Viox, Ahmed Fahad, Alberto Cagigi, Kwanyee Leung, Eun Sung Yang, Wing-Pui Kong, William Voss, Aaron G. Schmidt, M. Anthony Moody, David Ambrozak, Amy R. Henry, Farida Laboune, Julie E. Ledgerwood, Barney S. Graham, Mark Connors, Daniel C. Douek, Nancy Sullivan, Andrew D. Ellington, George Georgiou
Publikováno v:
The Journal of Immunology. 200:174.2-174.2
Next-Generation sequencing has become an essential tool in the analysis of antibody responses in the settings of health, vaccination, and disease. However, immune receptors comprise two chains encoded by separate mRNA strands, and conventional NextGe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bbf67d3591a220db7492219607e3d1d
https://doi.org/10.4049/jimmunol.200.supp.174.2
https://doi.org/10.4049/jimmunol.200.supp.174.2
Autor:
Matthias Tenbusch, Klaus Überla, Thomas Niezold, Drew Hannaman, Thomas Grunwald, S. Norley, M. Storcksdieck genannt Bonsmann
Publikováno v:
Vaccine. 28:3273-3277
DNA electroporation is a powerful vaccine strategy that could be rapidly adapted to address emerging viruses. We therefore compared cellular and humoral immune responses in mice vaccinated with DNA expression plasmids encoding either the wildtype or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc05b1e7d415005bb45e710f3060d7d4
https://doi.org/10.1016/j.vaccine.2010.02.090
https://doi.org/10.1016/j.vaccine.2010.02.090
Autor:
Drew Hannaman, Klaus Überla, Michael Storcksdieck genannt Bonsmann, Matthias Tenbusch, Thomas Niezold
Publikováno v:
Vaccine. 34(15)
Despite more than three decades of intense research, a prophylactic HIV-1 vaccine remains elusive. Four vaccine modalities have been evaluated in clinical efficacy studies, but only one demonstrated at least modest efficacy, which correlated with pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee35c9634901712f975a1119d532fe8
https://pubmed.ncbi.nlm.nih.gov/26945099
https://pubmed.ncbi.nlm.nih.gov/26945099
Autor:
Vladimir Temchura, Thomas Niezold, Matthias Tenbusch, André Maaske, Wiebke Hansen, Klaus Überla, Drew Hannaman, Michael Storcksdieck genannt Bonsmann, Vanessa Heinecke, Jan Buer, Christina Ehrhardt
Targeting of antigens to the endocytic uptake receptor DEC205 resulted in enhanced antigen presentation by dendritic cells (DCs). In combination with adjuvants for DC maturation, proteins coupled to an antibody against DEC205 induced strong pathogen-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f825f69f8562340ec0a1c15b9a89a5f3
https://www.ncbi.nlm.nih.gov/pubmed/25819746
https://www.ncbi.nlm.nih.gov/pubmed/25819746
Autor:
Christina Ehrhardt, Klaus Überla, Bettina Tippler, Sandra Nitsche, Drew Hannaman, Andrea Wiechers, Michael Storcksdieck genannt Bonsmann, Thomas Grunwald, Viktoria Stab, Matthias Tenbusch, Thomas Niezold
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e72217 (2013)
PLoS ONE, Vol 8, Iss 8, p e72217 (2013)
The Respiratory Syncytial Virus (RSV) and Influenza A Virus (IAV) are both two major causative agents of severe respiratory tract infections in humans leading to hospitalization and thousands of deaths each year. In this study, we evaluated the immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288d998a6d2b08e2d08dcecf8eedb815
http://europepmc.org/articles/PMC3743785
http://europepmc.org/articles/PMC3743785