Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Thomas Nicol"'
Autor:
Sandy M. Chu, Lisa C. Heather, Surawee Chuaiphichai, Thomas Nicol, Benjamin Wright, Matthieu Miossec, Jennifer K. Bendall, Gillian Douglas, Mark J. Crabtree, Keith M. Channon
Publikováno v:
Experimental Physiology, Vol 108, Iss 6, Pp 874-890 (2023)
Abstract Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide (NO) synthases in which its production of NO is crucial for cardiac function. However, non‐canonical roles of BH4 have been discovered recently and the cell‐specific rol
Externí odkaz:
https://doaj.org/article/61590d2d50ea48dca07378de1d92d796
Autor:
Youssef Khalil, Sara Carrino, Fujun Lin, Anna Ferlin, Heena V. Lad, Francesca Mazzacuva, Sara Falcone, Natalie Rivers, Gareth Banks, Danilo Concas, Carlos Aguilar, Andrew R. Haynes, Andy Blease, Thomas Nicol, Raya Al-Shawi, Wendy Heywood, Paul Potter, Kevin Mills, Daniel P. Gale, Peter T. Clayton
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 987 (2022)
Peroxisomal fatty acid α-oxidation is an essential pathway for the degradation of β-carbon methylated fatty acids such as phytanic acid. One enzyme in this pathway is 2-hydroxyacyl CoA lyase (HACL1), which is responsible for the cleavage of 2-hydro
Externí odkaz:
https://doaj.org/article/ba28623c2e524abd8d7b6ebf4ad93ca2
Autor:
Jade D. Bailey, Marina Diotallevi, Thomas Nicol, Eileen McNeill, Andrew Shaw, Surawee Chuaiphichai, Ashley Hale, Anna Starr, Manasi Nandi, Elena Stylianou, Helen McShane, Simon Davis, Roman Fischer, Benedikt M. Kessler, James McCullagh, Keith M. Channon, Mark J. Crabtree
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 218-230.e7 (2019)
Summary: Classical activation of macrophages (M(LPS+IFNγ)) elicits the expression of inducible nitric oxide synthase (iNOS), generating large amounts of NO and inhibiting mitochondrial respiration. Upregulation of glycolysis and a disrupted tricarbo
Externí odkaz:
https://doaj.org/article/cc2fff285c5a45c9a7e1583fa7e6da7b
Autor:
Paul K. Potter, Michael R. Bowl, Prashanthini Jeyarajan, Laura Wisby, Andrew Blease, Michelle E. Goldsworthy, Michelle M. Simon, Simon Greenaway, Vincent Michel, Alun Barnard, Carlos Aguilar, Thomas Agnew, Gareth Banks, Andrew Blake, Lauren Chessum, Joanne Dorning, Sara Falcone, Laurence Goosey, Shelley Harris, Andy Haynes, Ines Heise, Rosie Hillier, Tertius Hough, Angela Hoslin, Marie Hutchison, Ruairidh King, Saumya Kumar, Heena V. Lad, Gemma Law, Robert E. MacLaren, Susan Morse, Thomas Nicol, Andrew Parker, Karen Pickford, Siddharth Sethi, Becky Starbuck, Femke Stelma, Michael Cheeseman, Sally H. Cross, Russell G. Foster, Ian J. Jackson, Stuart N. Peirson, Rajesh V. Thakker, Tonia Vincent, Cheryl Scudamore, Sara Wells, Aziz El-Amraoui, Christine Petit, Abraham Acevedo-Arozena, Patrick M. Nolan, Roger Cox, Anne-Marie Mallon, Steve D. M. Brown
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute
Externí odkaz:
https://doaj.org/article/fa97ab87303c498f824c8286a0325379
Autor:
Michael J. Randles, Rachel Lennon, Anton Page, Charles D. Pusey, A Blease, Thomas Nicol, Sara Falcone, Elizabeth M. Angus, Paul Potter, Frederick W.K. Tam
Publikováno v:
Kidney International. 101:527-540
Nephrotic syndrome is characterized by severe proteinuria, hypoalbuminaemia, edema and hyperlipidaemia. Genetic studies of nephrotic syndrome have led to the identification of proteins playing a crucial role in slit diaphragm signaling, regulation of
Autor:
Mark J. Crabtree, Keith M. Channon, Ben Davies, Eileen McNeill, Andrew Shaw, Jade Bailey, Faseeha Ayaz, Thomas Nicol, Marina Diotallevi
Publikováno v:
Journal of Visualized Experiments.
Autor:
Sandy Minyin Chu, Lisa Claire Heather, Surawee Chuaiphichai, Thomas Nicol, Benjamin Wright, Matthieu Miossec, Helen Lockstone, Jennifer K. Bendall, Gillian Douglas, Mark James Crabtree, Keith Channon
Publikováno v:
SSRN Electronic Journal.
Autor:
Sandy Chu, Lisa Heather, Surawee Chuaiphichai, Thomas Nicol, Gillian Douglas, Mark Crabtree, Keith Channon
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:125
Autor:
Thomas, Nicol
Publikováno v:
Analysis (1324-5155). 2019, Issue 22, p105-108. 4p.
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