Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Thomas Nalpathamkalam"'
Autor:
Ada J. S. Chan, Worrawat Engchuan, Miriam S. Reuter, Zhuozhi Wang, Bhooma Thiruvahindrapuram, Brett Trost, Thomas Nalpathamkalam, Carol Negrijn, Sylvia Lamoureux, Giovanna Pellecchia, Rohan V. Patel, Wilson W. L. Sung, Jeffrey R. MacDonald, Jennifer L. Howe, Jacob Vorstman, Neal Sondheimer, Nicole Takahashi, Judith H. Miles, Evdokia Anagnostou, Kristiina Tammimies, Mehdi Zarrei, Daniele Merico, Dimitri J. Stavropoulos, Ryan K. C. Yuen, Bridget A. Fernandez, Stephen W. Scherer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Morphological subtypes of autism spectrum disorder (ASD) may differ in their genetic bases. Chan et al. develop a method for calculating a patient-level, genome-wide rare variant score and find significant differences in rare and common variant assoc
Externí odkaz:
https://doaj.org/article/daff05382e894c1ca9c8df1af30b6dc7
Autor:
Sharon Clouthier, Marek Tomczyk, Tamara Schroeder, Cheryl Klassen, André Dufresne, Eveline Emmenegger, Thomas Nalpathamkalam, Zhuozhi Wang, Bhooma Thiruvahindrapuram
Publikováno v:
Pathogens, Vol 12, Iss 9, p 1115 (2023)
Herpesvirus infections of sturgeon pose a potential threat to sturgeon culture efforts worldwide. A new epitheliotropic herpesvirus named Acipenser herpesvirus 3 (AciHV-3) was detected in hatchery-reared Lake Sturgeon Acipenser fulvescens displaying
Externí odkaz:
https://doaj.org/article/8df8867407ca427584c9998607d4bf66
Autor:
Cathy Boscarino, Thomas Nalpathamkalam, Giovanna Pellecchia, Weili Li, Bhooma Thiruvahindrapuram, Daniele Merico
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 2, Pp 463-471 (2019)
Post-traumatic stress disorder is a concerning psychobehavioral disorder thought to emerge from the complex interaction between genetic and environmental factors. For soldiers exposed to combat, the risk of developing this disorder is twofold and dia
Externí odkaz:
https://doaj.org/article/ac45292a957b41c59ce1a9414cca973d
Autor:
Roozbeh Manshaei, Daniele Merico, Miriam S. Reuter, Worrawat Engchuan, Bahareh A. Mojarad, Rajiv Chaturvedi, Tracy Heung, Giovanna Pellecchia, Mehdi Zarrei, Thomas Nalpathamkalam, Reem Khan, John B. A. Okello, Eriskay Liston, Meredith Curtis, Ryan K. C. Yuen, Christian R. Marshall, Rebekah K. Jobling, Erwin Oechslin, Rachel M. Wald, Candice K. Silversides, Stephen W. Scherer, Raymond H. Kim, Anne S. Bassett
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Recent genome-wide studies of rare genetic variants have begun to implicate novel mechanisms for tetralogy of Fallot (TOF), a severe congenital heart defect (CHD). To provide statistical support for case-only data without parental genomes, we re-anal
Externí odkaz:
https://doaj.org/article/146cab81df634ca49addda31257411e3
Autor:
Graham C. Gilchrist, Allison Tscherner, Thomas Nalpathamkalam, Daniele Merico, Jonathan LaMarre
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 3, p 396 (2016)
Successful fertilization and subsequent embryo development rely on complex molecular processes starting with the development of oocyte competence through maturation. MicroRNAs (miRNAs) are small non-coding RNA molecules that function as gene regulato
Externí odkaz:
https://doaj.org/article/3ad70a68ff4d406198a4215746c5bbce
Autor:
Mehdi Zarrei, Christie L Burton, Worrawat Engchuan, Edward J Higginbotham, John Wei, Sabah Shaikh, Nicole M Roslin, Jeffrey R MacDonald, Giovanna Pellecchia, Thomas Nalpathamkalam, Sylvia Lamoureux, Roozbeh Manshaei, Jennifer Howe, Brett Trost, Bhooma Thiruvahindrapuram, Christian R Marshall, Ryan K C Yuen, Richard F Wintle, Lisa J Strug, Dimitri J Stavropoulos, Jacob A S Vorstman, Paul Arnold, Daniele Merico, Marc Woodbury-Smith, Jennifer Crosbie, Russell J Schachar, Stephen W Scherer
Publikováno v:
Human Molecular Genetics.
We assessed the relationship of gene copy number variation (CNV) in mental health/neurodevelopmental traits and diagnoses, physical health and cognition in a community sample of 7100 unrelated children and youth of European or East Asian ancestry (Sp
Autor:
Maryam Oskoui, Mehdi Zarrei, Worrawat Engchuan, Neal Sondheimer, Bhooma Thiruv, Edward Higginbotham, Ritesh Thapa, Tarannum Behlim, Sabrina Aimola, John Wei, Prakroothi Danthi, Giovanna Pellecchia, Karen Ho, Jill de Rijke, Jennifer Howe, Thomas Nalpathamkalam, Roozbeh Manshaei, Joseph Whitney, Rohan Patel, Omar Hamdan, Rulan Shaath, Shannon Knights, Brett Trost, Dawa Samdup, ANNA MCCORMICK, Carolyn Hunt, Adam Kirton, Anne Kawamura, Ronit Mesterman, Jan Willem Gorter, Nomazulu Dlamini, Daniele Merico, Ryan Yuen, Michael Shevell, Dimitri Stavropoulos, Richard Wintle, Darcy Fehlings, Stephen Scherer
Publikováno v:
Thursday, April 27.
Autor:
Mehdi Zarrei, Christie L. Burton, Worrawat Engchuan, Edward J Higginbotham, John Wei, Sabah Shaikh, Nicole M. Roslin, Jeffrey R. MacDonald, Giovanna Pellecchia, Thomas Nalpathamkalam, Sylvia Lamoureux, Roozbeh Manshaei, Jennifer Howe, Brett Trost, Bhooma Thiruvahindrapuram, Christian R. Marshall, Ryan K.C. Yuen, Richard F. Wintle, Lisa J Strug, Dimitri J. Stavropoulos, Jacob A.S. Vorstman, Paul Arnold, Daniele Merico, Marc Woodbury-Smith, Jennifer Crosbie, Russell Schachar, Stephen W. Scherer
We assessed the relationship of gene copy number variation (CNV) in mental health/neurodevelopmental traits and diagnoses, physical health, and cognitive biomarkers in a community sample of 7,100 unrelated European, and East Asian children and youth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27bad47117de3a4ac65525ca3c63401a
https://doi.org/10.1101/2022.09.12.22279764
https://doi.org/10.1101/2022.09.12.22279764
Genomic architecture of Autism Spectrum Disorder from comprehensive whole-genome sequence annotation
Autor:
Brett Trost, Bhooma Thiruvahindrapuram, Ada J.S. Chan, Worrawat Engchuan, Edward J. Higginbotham, Jennifer L. Howe, Livia O. Loureiro, Miriam S. Reuter, Delnaz Roshandel, Joe Whitney, Mehdi Zarrei, Matthew Bookman, Cherith Somerville, Rulan Shaath, Mona Abdi, Elbay Aliyev, Rohan V. Patel, Thomas Nalpathamkalam, Giovanna Pellecchia, Omar Hamdan, Gaganjot Kaur, Zhuozhi Wang, Jeffrey R. MacDonald, John Wei, Wilson W.L. Sung, Sylvia Lamoureux, Ny Hoang, Thanuja Selvanayagam, Nicole Deflaux, Melissa Geng, Siavash Ghaffari, John Bates, Edwin J. Young, Qiliang Ding, Carole Shum, Lia D’abate, Clarissa A. Bradley, Annabel Rutherford, Vernie Aguda, Beverly Apresto, Nan Chen, Sachin Desai, Xiaoyan Du, Matthew L.Y. Fong, Sanjeev Pullenayegum, Kozue Samler, Ting Wang, Karen Ho, Tara Paton, Sergio L. Pereira, Jo-Anne Herbrick, Richard F. Wintle, Jonathan Fuerth, Juti Noppornpitak, Heather Ward, Patrick Magee, Ayman Al Baz, Usanthan Kajendirarajah, Sharvari Kapadia, Jim Vlasblom, Monica Valluri, Joseph Green, Vicki Seifer, Morgan Quirbach, Olivia Rennie, Elizabeth Kelley, Nina Masjedi, Catherine Lord, Michael J. Szego, Ma’n H. Zawati, Michael Lang, Lisa J. Strug, Christian R. Marshall, Gregory Costain, Kristina Calli, Alana Iaboni, Afiqah Yusuf, Patricia Ambrozewicz, Louise Gallagher, David G. Amaral, Jessica Brian, Mayada Elsabbagh, Stelios Georgiades, Daniel S. Messinger, Sally Ozonoff, Jonathan Sebat, Calvin Sjaarda, Isabel M. Smith, Peter Szatmari, Lonnie Zwaigenbaum, Azadeh Kushki, Thomas W. Frazier, Jacob A.S. Vorstman, Khalid A. Fakhro, Bridget A. Fernandez, M.E. Suzanne Lewis, Rosanna Weksberg, Marc Fiume, Ryan K.C. Yuen, Evdokia Anagnostou, Neal Sondheimer, David Glazer, Dean M. Hartley, Stephen W. Scherer
Fully understanding the genetic factors involved in Autism Spectrum Disorder (ASD) requires whole-genome sequencing (WGS), which theoretically allows the detection of all types of genetic variants. With the aim of generating an unprecedented resource
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b717e0844196ee000bbf7582208abb19
https://doi.org/10.1101/2022.05.05.22274031
https://doi.org/10.1101/2022.05.05.22274031
Autor:
Jacob A. S. Vorstman, Evdokia Anagnostou, Daniele Merico, Jeffrey R. MacDonald, Jennifer L. Howe, Zhuozhi Wang, Ryan K. C. Yuen, Thomas Nalpathamkalam, Judith H. Miles, Carol Negrijn, Miriam S. Reuter, Neal Sondheimer, Bridget A. Fernandez, Stephen W. Scherer, Wilson W L Sung, Kristiina Tammimies, Rohan V. Patel, Worrawat Engchuan, Giovanna Pellecchia, Nicole Takahashi, Mehdi Zarrei, Ada J.S. Chan, Dimitri J. Stavropoulos, Bhooma Thiruvahindrapuram, Sylvia Lamoureux, Brett Trost
Defining different genetic subtypes of autism spectrum disorder (ASD) can enable the prediction of developmental outcomes. Based on minor physical and major congenital anomalies, we categorized 325 Canadian children with ASD into dysmorphic and nondy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7de69aa76112317c617021b391f0c972
https://doi.org/10.1101/2021.10.20.21264950
https://doi.org/10.1101/2021.10.20.21264950