Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Thomas N. Tozer"'
Publikováno v:
Journal of Occupational & Environmental Medicine. 40:230-240
Styrene is a widely used industrial solvent associated with acute neurotoxicity. To investigate the relationships between exposure, blood concentrations, and the appearance of neurotoxic effects, four healthy males were exposed to styrene concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426f284570598c4595b584d3fe64588c
https://doi.org/10.1097/00043764-199803000-00005
https://doi.org/10.1097/00043764-199803000-00005
Publikováno v:
Pharmaceutical Research. 15:98-104
Purpose. Evaluating of the effects of high intrasubject variability in clearance (CL) and volume of distribution (V), on 90% confidence intervals (CIs) for AUC (Area Under the concentration Curve) in single and multiple-dose bioequivalence studies. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3b4a5a67fb26628ef9ad4c5c8513fd2
https://doi.org/10.1023/a:1011961006297
https://doi.org/10.1023/a:1011961006297
Publikováno v:
The American Journal of Clinical Nutrition. 66:1165-1171
Ascorbic acid (vitamin C) is commonly used as a dietary supplement, often in megadoses. However, as the daily oral dose is increased, the concentration of ascorbic acid in the plasma and other body fluids does not increase proportionally, but instead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22940afb6fa9b089f4ce1024dd8bb77
https://doi.org/10.1093/ajcn/66.5.1165
https://doi.org/10.1093/ajcn/66.5.1165
Publikováno v:
Pharmaceutical Research. 13:453-456
Purpose. The goals were to evaluate the usefulness of Cmax/AUClqc, ratio of the maximum plasma drug concentration to the area under the plasma concentration-time curve to the time of the last quantifiable concentration, in bioequivalence testing and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ac79a25b05ab24565ae557c46d19d32
https://doi.org/10.1023/a:1016061013606
https://doi.org/10.1023/a:1016061013606
Publikováno v:
Clinical Research and Regulatory Affairs. 12:249-265
Regulations for approval of new generic pharmaceutical products often involve multiple requirements. for example, most countries include requirements for both total and peak exposures to the drug (AUC and CMAX) to be approved, the new product must sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9d26d1ff04f93d34a49ba61186d3249
https://doi.org/10.3109/10601339509019618
https://doi.org/10.3109/10601339509019618
Publikováno v:
Journal of Pharmaceutical Sciences. 83:1284-1288
Chronic colitis, e.g., ulcerative colitis and Crohn's disease, is presently treated with glucocorticoids and other antiinflammatory agents. Side effects limit chronic glucocorticoid therapy. The dose, and consequently the side effects, may be reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2c457ffcb238729a40e259626aa396
https://doi.org/10.1002/jps.2600830919
https://doi.org/10.1002/jps.2600830919
Autor:
Thomas N. Tozer, Frédéric Y. Bois, Walter W. Hauck, Rabindra Patnaik, Roger L. Williams, Mei-Ling Chen
Publikováno v:
Pharmaceutical Research. 11:966-974
The highest point of the plasma concentration-time profile, Cmax , is currently used by regulatory agencies to assess the rate of drug absorption after single dose administration of oral products. It is, however, quite insensitive, and a number of ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e27da1e89de3c951432d7eed6b8d20cc
https://doi.org/10.1023/a:1018970901116
https://doi.org/10.1023/a:1018970901116
Publikováno v:
International Journal of Pharmaceutics. 92:105-114
Dextran ester prodrugs have been proposed as a means of delivering drug to the colon. In this study, methylprednisolone and dexamethasone were covalently attached to dextran (Mw = 72 600) by the use of a succinate linker. In addition, dexamethasone w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f47e54f81e2acca15e0ed84c20745809
https://doi.org/10.1016/0378-5173(93)90269-l
https://doi.org/10.1016/0378-5173(93)90269-l
Publikováno v:
Human & Experimental Toxicology. 12:215-225
1 Pentachlorophenol (PCP) has been found to be carcinogenic in mice. The objective of this study was to extrapolate to humans the risk of cancer from data obtained in mice using information on disposition, serum protein binding and metabolism of PCP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb38d6c363395b6652a9556e2117a3a
https://doi.org/10.1177/096032719301200304
https://doi.org/10.1177/096032719301200304