Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Thomas N. Thompson"'
Autor:
Eric C. D. Tan, Kylee Harris, Stephen M. Tifft, Darlene Steward, Christopher Kinchin, Thomas N. Thompson
Publikováno v:
Biofuels, Bioproducts and Biorefining. 16:942-961
Autor:
Thomas N. Thompson
Publikováno v:
Australian Journal of International Affairs. 69:357-362
There’s no virtue in cultural ignorance. Yet until recently it’s been easy to view the headlines proclaiming ‘China’s turn to the sea’ as something strikingly different from the image of China that...
Autor:
Thomas L. Horn, David L. McCormick, Thomas N. Thompson, Izet M. Kapetanovic, Levy Kopelovich, Chinthalapally V. Rao, Miguel Muzzio, William D. Johnson, Altaf Mohammed
Publikováno v:
Cancer Chemotherapy and Pharmacology. 69:1301-1306
CP-31398 (N′-[2-[(E)-2-(4-methoxyphenyl)ethenyl]quinazolin-4-yl]-N,N-dimethylpropane-1,3-diamine hydrochloride) is one of the new class of agents that can stabilize the DNA-binding domain of p53 and thereby maintain the activity of p53 as a tumor s
Publikováno v:
Journal of Medicinal Chemistry. 45:304-311
This paper describes a graphical model for simplifying in vitro absorption, metabolism, distribution, and elimination (ADME) data analysis through the estimation of oral bioavailability (%F) of drugs in humans and other species. This model integrates
Autor:
Herbert W. Behlow, Michael L. Avery, Kenneth W. Otis, Dennis O. Scott, Suzanne M. Broward-Partin, Thomas N. Thompson, Dannette K. Hansen
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 45:71-77
Combinatorial synthesis and high-throughput pharmacology screening have greatly increased compound throughput in modern drug-discovery programs. For CNS drugs, it is also important to determine permeability to the blood--brain barrier. Yet, given the
Publikováno v:
Biopharmaceutics & Drug Disposition. 18:743-751
The mass balance of 14C bismuth sucrose octasulfate (BISOS) was investigated in eight male Sprague-Dawley rats after single oral doses of 1.0 g kg-1. Bismuth and radioactivity were monitored in blood, urine, and feces for up to 144 h post-dose, while
Autor:
Julie L. Geary, Melinda A. Correll, J. Chuck Poole, Xiao-Gao Liu, Larry D. Bratton, Fred E. Boyer, Thomas N. Thompson, Teng-Man Chen, Arun K. Mandagere, Bryan K. Jones, Kin-Kai Hwang, Mark E. Webster, Robert W. Knippenberg, Maynard George D, Stephen W. Horgan, Deborah E. Logan, Tieu-Binh Le, Kudlacz Elizabeth M, David L. Wenstrup, Burkholder Timothy P, Raymond S. Gross, David W. Freund
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2531-2536
We recently described the synthesis and characterization of MDL 105,212, a non peptide tachykinin antagonist with high affinity for NK1 and NK2 receptors.1 Here we report the synthesis and structure-activity relationships for a series of analogs of M
Autor:
Thomas N. Thompson
Publikováno v:
Pharmacokinetics in Drug Development ISBN: 9781441979360
The field of drug transporters has exploded over the past 30 years. It is now known that transporters are located in virtually every organ and tissue in the body and are involved in every aspect of drug absorption, distribution, excretion, and even i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63a9929be34eeadb09a67603e6e75922
https://doi.org/10.1007/978-1-4419-7937-7_13
https://doi.org/10.1007/978-1-4419-7937-7_13
Autor:
Judevin Lugar, Kevin P. Quinn, Anna Liao, Darren B. Dressen, Linda Chen, Thomas N. Thompson, Elizabeth J. Holsztynska, Francine S. Farouz, Whitney Dunn, Christopher Vandevert, Ying-Zi Xu, Michael Jefferies, Thorsett Eugene D, Mark Dreyer, Michael A. Pleiss, Ted Yednock, Andrei W. Konradi, Stephen B. Freedman, Linda Mutter, Semko Christopher M
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(6)
A series of N-(pyrimidin-4-yl)-phenylalanine VLA-4 antagonists is described. Optimization of substituents at the 2 and 5 positions of the pyrimidine ring gave 14, a very potent VLA-4 inhibitor which is orally active in a sheep asthma model.
Publikováno v:
Cancer chemotherapy and pharmacology. 68(3)
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a naturally occurring polyphenol with a broad range of possible health benefits, including anti-cancer activity. However, the biological activity of resveratrol may be limited by poor absorption and f