Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Thomas N. Salzmann"'
1
The discovery and synthesis of 2-biphenylcarbapenems active against methicillin resistant staphylococci
Autor: Thomas N. Salzmann, Jean S. Kahan, Frank P. DiNinno, Joann Huber, David A. Muthard, Helmut Kropp
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:945-948
The discovery and synthesis of the arylcarbapenem 2b possessing potent activity against highly resistant strains of methicillin resistant staphylococci are dislosed.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f5a88691499395fd1cb8d0b4d959eb2
https://doi.org/10.1016/0960-894x(95)00149-n
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2
The synthesis and antibacterial activity of 2-para-quarternary ammoniomethylphenyl-carbapenems
Autor: Thomas N. Salzmann, Frank P. DiNinno, David A. Muthard
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:2187-2192
The synthesis and in vitro antibacterial activity of 2-phenylcarbapenems bearing a spacer linked heteroaromatic or heterocyclic quaternized moiety are discussed. In general, this class of antibiotics was found to possess antibacterial activity superi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5af88b85ea0829cd670b34d3cfd914c3
https://doi.org/10.1016/s0960-894x(01)80923-9
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3
ChemInform Abstract: The Discovery and Synthesis of 2-Biphenylcarbapenems Active Against Methicillin Resistant Staphylococci
Autor: Thomas N. Salzmann, Frank P. DiNinno, Helmut Kropp, Joann Huber, David A. Muthard, Jean S. Kahan
Publikováno v: ChemInform. 26
The discovery and synthesis of the arylcarbapenem 2b possessing potent activity against highly resistant strains of methicillin resistant staphylococci are dislosed.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3b925c1defd4c6a99d468b1d05c1b1b
https://doi.org/10.1002/chin.199537276
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4
ChemInform Abstract: 2-Naphthylcarbapenems: Broad Spectrum Antibiotics with Enhanced Potency Against MRSA
Autor: Cynthia Jaworsky, Jeffrey J. Herrmann, Mark L. Greenlee, Frank P. DiNinno, Thomas N. Salzmann, David A. Muthard
Publikováno v: ChemInform. 31
A regioisomeric set of 2-naphthylcarbapenems featuring cationic substituents was synthesized. Optimal placement of the cationic group was found to markedly improve activity against methicillin-resistant staphylococci while maintaining a good spectrum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aae275d8823d694067606b388e109b55
https://doi.org/10.1002/chin.200007211
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5
2-Naphthylcarbapenems: broad spectrum antibiotics with enhanced potency against MRSA
Autor: Thomas N. Salzmann, Jeffrey J. Herrmann, Mark L. Greenlee, David A. Muthard, Frank P. DiNinno, Cynthia Jaworsky
Publikováno v: Bioorganicmedicinal chemistry letters. 9(19)
A regioisomeric set of 2-naphthylcarbapenems featuring cationic substituents was synthesized. Optimal placement of the cationic group was found to markedly improve activity against methicillin-resistant staphylococci while maintaining a good spectrum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5031b0ae3de3870aa0cbb7b0d0a9b1
https://pubmed.ncbi.nlm.nih.gov/10522713
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6
A new approach to the diastereoselective synthesis of aldols:Introduction of the 6α-(1R-hydroxyethyl) side chain of the carbapenem and penem antibiotics
Autor: F.A. Bouffard, Thomas N. Salzmann
Publikováno v: Tetrahedron Letters. 26:6285-6288
The 6 α-(1R-hydroxyethyl) side chain has been introduced via a stereocontrolled aldol reaction with a silyl ketone as a hindered acetaldehyde equivalent. The derived trans-S silyl carbinol undergoes a completely stereospecific rearrangement to the d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::581f9d8238a9d1a652bcb1cedbe82ff6
https://doi.org/10.1016/s0040-4039(01)84578-0
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7
Modification of natural products to improve their biological properties
Autor: M. F. Woods, R. N. Guthikonda, B. G. Christensen, M. Quesada, Thomas N. Salzmann, Lovji D. Cama
Publikováno v: Pure and Applied Chemistry. 59:455-458
Natural products often do not possess the optimal properties for their use in human or animal medicine. The recent history of natural products would indicate that such optimization is likely. 2-Aryl-carbapenems were synthesized in an effort to improv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad459e0f229fceb3fb241e94e9d2a79f
https://doi.org/10.1351/pac198759030455
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10
A novel synthesis of the carbapen-2-em ring system
Autor: B. G. Christensen, Ronald W. Ratcliffe, Thomas N. Salzmann
Publikováno v: Tetrahedron Letters. 21:31-34
A new synthesis of the carbapenem ring system, as found in thienamycin and related natural products, has been developed. The key step involves a highly efficient carbene insertion reaction which produces the bicyclic ring system by forming the N3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a3cfba735345fd301bf9bf90324ec8d
https://doi.org/10.1016/s0040-4039(00)93616-5
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