Výsledky vyhledávání - "Thomas N. Plasterer"

The Art and Practice of Systems Biology in Medicine: Mapping Patterns of Relationships

Autor: Stephen A. Martin, Peter Juhasz, Robert N. McBurney, Aram Adourian, Thomas N. Plasterer, Elwin Verheij, J. van der Greef

Publikováno v: Journal of Proteome Research, 4, 6, 1540-1559

Systems biology has developed in recent years from a technology-driven enterprise to a new strategic tool in Life Sciences, particularly for innovative drug discovery and drug development. Combining the ultimate in systems phenotyping with in-depth i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e8c27b0b8d5d4cae1d0b3ad1ae1962
https://doi.org/10.1021/pr0606530

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Phenotype Characterisation Using Integrated Gene Transcript, Protein and Metabolite Profiling

Autor: Clary B. Clish, Louis M. Havekes, Matej Orešič, Eugene Davidov, Thomas N. Plasterer, Jan van der Greef, Elwin Verheij, Aram Adourian, Stephen Naylor, Eric K. Neumann, Jack T. W. E. Vogels

Publikováno v: Orešič, M, Clish, C B, Davidov, E J, Verheij, E, Vogels, J, Havekes, L M, Neumann, E, Adourian, A, Naylor, S, van der Greef, J & Plasterer, T 2004, ' Phenotype characterisation using integrated gene transcript, protein and metabolite profiling ', Applied Bioinformatics, vol. 3, no. 4, pp. 205-217 . https://doi.org/10.2165/00822942-200403040-00002
Applied Bioinformatics, 4, 3, 205-217

Multifactorial diseases present a significant challenge for functional genomics. Owing to their multiple compartmental effects and complex biomolecular activities, such diseases cannot be adequately characterised by changes in single components, nor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88aa41ec7bf3556b42628617c30f6531
https://doi.org/10.2165/00822942-200403040-00002

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PROTEAN: Protein Sequence Analysis and Prediction

Autor: Thomas N. Plasterer

Publikováno v: Molecular Biotechnology. 16:117-126

The archaeal, bacterial, andeukaryotic genome projects have overwhelmed our ability to experimentally elucidate the function of each novel gene and gene product. To a certain extent, protein functional assignments can be derived via sequence similari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61028cdb9fe183acbfdddfd91245d3f
https://doi.org/10.1385/mb:16:2:117

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Systems Pharmacology, Biomarkers, and Biomolecular Networks

Autor: Jan van der Greef, Pieter Muntendam, Stephen A. Martin, Noubar B. Afeyan, Ezra G. Jennings, Robert N. McBurney, Aram Adourian, Raji Balasubramanian, Shunguang Wang, Thomas N. Plasterer

Publikováno v: Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b8f8d53f0066212fcd7f1619dba7034
https://doi.org/10.1002/9780470431818.ch4

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Correlation network analysis for data integration and biomarker selection

Autor: Ivana Bobeldijk, Thomas N. Plasterer, Ulf Andersson, Wade M. Hines, Kerstin Kenne, Paul Stroobant, Doris Damian, Jan van der Greef, Ina Schuppe-Koistinen, Kerstin Nilsson, Ezra G. Jennings, Elwin Verheij, Clary B. Clish, Robert N. McBurney, Heike Hellmold, Hugh Salter, Johan Lindberg, Aram Adourian, Raji Balasubramanian

Publikováno v: Molecular BioSystems, 3, 4, 249-259

High-throughput biomolecular profiling techniques such as transcriptomics, proteomics and metabolomics are increasingly being used in in vivo studies to recognize and characterize effects of xenobiotics on organs and systems. Of particular interest a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4dd7ff62b7f2130226ef272667c1f53
http://resolver.tudelft.nl/uuid:a01709bc-1ec3-4fa7-8535-0c284a8948e4

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Integrative biological analysis of the APOE*3-leiden transgenic mouse

Publikováno v: Clish, C B, Davidov, E, Orešič, M, Plasterer, T N, Lavine, G, Londo, T, Meys, M, Snell, P, Stochaj, W, Adourian, A, Zhang, X, Morel, N, Neumann, E, Verheij, E, Vogels, J T W E, Havekes, L M, Afeyan, N, Regnier, F, van der Greef, J & Naylor, S 2004, ' Integrative biological analysis of the APOE*3-leiden transgenic mouse ', OMICS: A Journal of Integrative Biology, vol. 8, no. 1, pp. 3-13 . https://doi.org/10.1089/153623104773547453
OMICS A Journal of Integrative Biology, 1, 8, 3-13

Integrative (or systems biology) is a new approach to analyzing biological entities as integrated systems of genetic, genomic, protein, metabolite, cellular, and pathway events that are in flux and interdependent. Here, we demonstrate the application

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21eb7ce8d0801278db4257c2343f33d
https://pubmed.ncbi.nlm.nih.gov/15107233

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Methods for the differential integrative Omic analysis of plasma from a transgenic disease animal model

Publikováno v: Davidov, E, Clish, C B, Orešič, M, Meys, M, Stochaj, W, Snell, P, Lavine, G, Londo, T R, Adourian, A, Zhang, X, Johnston, M, Morel, N, Marple, E W, Plasterer, T N, Neumann, E, Verheij, E, Vogels, J T W E, Havekes, L M, Van Der Greef, J & Naylor, S 2004, ' Methods for the differential integrative Omic analysis of plasma from a transgenic disease animal model ', OMICS: A Journal of Integrative Biology, vol. 8, no. 4, pp. 267-288 . https://doi.org/10.1089/omi.2004.8.267
OMICS A Journal of Integrative Biology, 4, 8, 267-288
Scopus-Elsevier

Multitiered quantitative analysis of biological systems is rapidly becoming the desired approach to study hierarchical functional interactions between proteins and metabolites. We describe here a novel systematic approach to analyze organisms with co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b32ef3ca299e2524a6ee251d106bbbe
https://cris.vtt.fi/en/publications/d2b25dbd-c357-4f00-acd4-97747d53bf89

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