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pro vyhledávání: '"Thomas N. Parks"'
The auditory system has a remarkable ability to adjust to an ever-changing environment. The six review chapters that comprise Plasticity of the Central Auditory System cover a spectrum of issues concerning this ability to adapt, defined by the widely
Publikováno v:
Journal of Neurochemistry. 74:179-191
Motoneurons have been shown to be particularly sensitive to Ca 2+ -dependent glutamate excitotoxicity, mediated via AMPA receptors (AMPARs). To determine the molecular basis for this susceptibility we have used immunocytochemistry, RT-PCR, and electr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc609143445ea491fb6ce2d28dda8135
https://doi.org/10.1046/j.1471-4159.2000.0740179.x
https://doi.org/10.1046/j.1471-4159.2000.0740179.x
Autor:
Thomas N. Parks, Lance Zirpel
Publikováno v:
Journal of the Association for Research in Otolaryngology. 2:180-187
Zinc is widely distributed in the central nervous system (CNS), it functions normally as a synaptic modulator, and it contributes to neuronal death under pathologic conditions. Zinc colocalizes with glutamate in excitatory synapses, and the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2529bbef1c3194504866dfe810682c1a
https://doi.org/10.1007/s101620010082
https://doi.org/10.1007/s101620010082
Autor:
Thomas N. Parks
Publikováno v:
Hearing Research. 147:77-91
The ionotropic glutamate receptor (GluR) subtype known as the AMPA receptor, which mediates rapid excitatory synaptic transmission in many regions of the nervous system, is composed of four different protein subunits, termed GluRs 1-4. The functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d103bef838fb78f82502640389462e88
https://doi.org/10.1016/s0378-5955(00)00122-2
https://doi.org/10.1016/s0378-5955(00)00122-2
Publikováno v:
The Journal of Neuroscience. 20:6267-6275
Although dependence on afferent synaptic activity has been shown for central neurons in every sensory system, the mechanisms of afferent maintenance of target sensory neurons are not understood. Neurons in the cochlear nucleus (CN) require afferent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df92f813c45a20af7cb2e5e8d1e3655
https://doi.org/10.1523/jneurosci.20-16-06267.2000
https://doi.org/10.1523/jneurosci.20-16-06267.2000
Publikováno v:
The Journal of Comparative Neurology. 421:95-106
Neurons of the chick cochlear nucleus, nucleus magnocellularis (NM), require eighth nerve activation of metabotropic glutamate receptors (mGluRs) for maintenance of intracellular calcium homeostasis. Interrupting this activation results in an increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d696b27aa20da97cad8ff00f1c8280af
https://doi.org/10.1002/(sici)1096-9861(20000522)421:1<95::aid-cne6>3.0.co
https://doi.org/10.1002/(sici)1096-9861(20000522)421:1<95::aid-cne6>3.0.co
Autor:
Brian Billups, Peter Guthrie, Elizabeth M. Muir, Thomas N. Parks, Nicola J. Hack, John H. Rogers, S. B. Kater
Publikováno v:
Journal of Neuroscience Methods. 95:177-184
Manipulating the expression of a protein can provide a powerful tool for understanding its function, provided that the protein is expressed at physiologically-significant concentrations. We have developed a simple method to measure (1) the concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c81a713ea06b6d2a1feb9bd5949999
https://doi.org/10.1016/s0165-0270(99)00178-8
https://doi.org/10.1016/s0165-0270(99)00178-8
Publikováno v:
Brain Research Protocols. 3:142-154
Glutamate activates three distinct classes of ionotropic receptors: AMPA, kainate and NMDA. AMPA receptors (AMPARs) are of particular importance as they mediate the majority of fast excitatory synaptic transmission and are implicated in a variety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d924abc35feb02cb589aaba282542c9
https://doi.org/10.1016/s1385-299x(98)00035-x
https://doi.org/10.1016/s1385-299x(98)00035-x
Publikováno v:
Molecular Brain Research. 50:143-153
To identify chick GluR4 isoforms, we used PCR to amplify a C-terminal region that is the site of alternative splicing in rat. We report here the cloning of three novel chick GluR4 isoforms. GluR4c has a 113-bp insert in the C-terminus, is expressed i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f1afc92588dc80f0d99c6f6d692e0d
https://doi.org/10.1016/s0169-328x(97)00179-4
https://doi.org/10.1016/s0169-328x(97)00179-4
Autor:
Lois Winsky, Dwan A. Taylor, Kenneth I. Strauss, Thomas N. Parks, Derek A. Solum, David M. Jacobowitz, Rebecca A Code
Publikováno v:
The Journal of Comparative Neurology. 383:112-121
The expression of the calcium-binding protein calretinin (CR) in the chick brainstem auditory nuclei angularis (NA), laminaris (NL), and magnocelularis (NM) was studied during normal development and after deafening by surgical removal of the otocyst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::681c6bed2be5db8b45a38fe406715c84
https://doi.org/10.1002/(sici)1096-9861(19970623)383:1<112::aid-cne9>3.0.co
https://doi.org/10.1002/(sici)1096-9861(19970623)383:1<112::aid-cne9>3.0.co