Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Thomas N Burn"'
Autor:
Susan N Christo, Keely M McDonald, Thomas N Burn, Nadia Kurd, Jessica Stanfield, Megan M Kaneda, Ruth Seelige, Christopher P Dillon, Timothy S Fisher, Bas Baaten, Laura K Mackay
Publikováno v:
Clinical & Translational Immunology, Vol 13, Iss 11, Pp n/a-n/a (2024)
Abstract Objectives Bispecific antibodies targeting CD47 and PD‐L1 (CD47 × PD‐L1 BisAb) demonstrate efficacy against a range of solid cancers. While dual blockade negates anti‐CD47‐mediated toxicity, the effect of combined innate and adaptiv
Externí odkaz:
https://doaj.org/article/6a8dad7b15e94e2b9af5d8772594ea0f
Autor:
Tamir Diamond, Thomas N Burn, Mailyn A Nishiguchi, Danielle Minichino, Julie Chase, Niansheng Chu, Portia A Kreiger, Edward M Behrens
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269553 (2022)
Interferon gamma (IFN-γ) is the main cytokine driving organ dysfunction in Familial Hemophagocytic Lymphohistiocytosis (FHL). Blockade of IFN-γ pathway ameliorates FHL hepatitis, both in animal models and in humans with FHL. Hepatocytes are known t
Externí odkaz:
https://doaj.org/article/0fcb53d025e74ae28392b294f706d544
Autor:
Cameron G. Williams, Marcela L. Moreira, Takahiro Asatsuma, Hyun Jae Lee, Shihan Li, Thomas N. Burn, Irving Barrera, Evan Murray, Megan S.F. Soon, Jessica A. Engel, David S. Khoury, Shirley Le, Brooke J. Wanrooy, Dominick Schienstock, Yannick O. Alexandre, Oliver P. Skinner, Rainon Joseph, Lynette Beattie, Scott N. Mueller, Fei Chen, Ashraful Haque
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114754- (2024)
Externí odkaz:
https://doaj.org/article/3eeba6fae4804717be2dfc45ba70fa91
Autor:
Raíssa Fonseca, Thomas N. Burn, Luke C. Gandolfo, Sapna Devi, Simone L. Park, Andreas Obers, Maximilien Evrard, Susan N. Christo, Frank A. Buquicchio, Caleb A. Lareau, Keely M. McDonald, Sarah K. Sandford, Natasha M. Zamudio, Nagela G. Zanluqui, Ali Zaid, Terence P. Speed, Ansuman T. Satpathy, Scott N. Mueller, Francis R. Carbone, Laura K. Mackay
Publikováno v:
Nature Immunology. 23:1236-1245
This is the accepted manuscript version of the work published in its final form as Fonseca, R., Burn, T. N., Gandolfo, L. C., Devi, S., Park, S. L., Obers, A., Evrard, M., Christo, S. N., Buquicchio, F. A., Lareau, C. A., McDonald, K. M., Sandford, S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe8853720abec5b4ac94e8693e2893f
https://doi.org/10.1038/s41590-022-01273-4
https://doi.org/10.1038/s41590-022-01273-4
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Danger signals mediated through ST2, the interleukin-33 (IL-33) receptor, amplify CD8+ T cell-mediated inflammation in the murine model of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), and blockade of ST2 provides a potential therapeutic
Externí odkaz:
https://doaj.org/article/6fb84064881544798bdadba38f3e88f8
Autor:
Axel Kallies, William R. Heath, Dane M. Newman, Nicholas D. Huntington, Thomas N. Burn, Andrew Lucas, Francis R. Carbone, Luke C. Gandolfo, Simone L Park, Terence P. Speed, Michaela Lucas, Natasha Zamudio, Fernando Souza-Fonseca-Guimaraes, Laura K. Mackay, Gabrielle T. Belz, Maximilien Evrard, Nicholas Collins, Laurent Bartholin, Wei Shi, Daniel G. Pellicci, Yannick O. Alexandre, Raissa Fonseca, Scott N. Mueller, David Chisanga, Florent Ginhoux, Susan N Christo
Publikováno v:
Nature Immunology. 22:1140-1151
Tissue-resident memory T (TRM) cells are non-recirculating cells that exist throughout the body. Although TRM cells in various organs rely on common transcriptional networks to establish tissue residency, location-specific factors adapt these cells t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b4be269bb56ae64479bd424fdaaa3b8
https://doi.org/10.1038/s41590-021-01004-1
https://doi.org/10.1038/s41590-021-01004-1
Autor:
George Kannourakis, Susan N Christo, Sapna Devi, Stuart P. Berzins, Erica Wynne-Jones, Daniel G. Pellicci, William R. Heath, Thomas N. Burn, Raissa Fonseca, Simone L Park, Scott N. Mueller, Jerold Chun, Laura K. Mackay, Changwei Peng, Maximilien Evrard, Stephen C. Jameson, Yu Kato, Maleika Osman
Publikováno v:
The Journal of Experimental Medicine
S1PR5 impairs TRM cell differentiation by limiting T cell entry and promoting T cell egress from peripheral tissues. Local TGF-β signaling coordinates suppression of the T-bet–ZEB2–S1PR5 emigration axis, thus enforcing tissue residency.
Tis
Tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64691341c4f5e2ca5127ca40b041abf5
https://doi.org/10.1084/jem.20210116
https://doi.org/10.1084/jem.20210116
Autor:
Scott M. Gordon, Charline Miot, Tamir Diamond, Craig H. Bassing, Erica Culberson, Ed Behrens, Thomas N. Burn, Katharina E. Hayer, Portia A. Kreiger, Anamika Bhattacharyya, Jessica M. Jones
RAG1/RAG2 (RAG) endonuclease-mediated assembly of diverse lymphocyte antigen receptor genes by V(D)J recombination is critical for the development and immune function of T and B cells. However, this process creates highly self-reactive cells that mus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9668323ec2af95ae2d305e6d2b32ea26
https://doi.org/10.1101/2021.01.04.425211
https://doi.org/10.1101/2021.01.04.425211
Autor:
Thomas N. Burn, Charline Miot, Scott M. Gordon, Erica J. Culberson, Tamir Diamond, Portia A. Kreiger, Katharina E. Hayer, Anamika Bhattacharyya, Jessica M. Jones, Craig H. Bassing, Edward M. Behrens
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 209(5)
RAG1/RAG2 (RAG) endonuclease-mediated assembly of diverse lymphocyte Ag receptor genes by V(D)J recombination is critical for the development and immune function of T and B cells. The RAG1 protein contains a ubiquitin ligase domain that stabilizes RA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae6b7198f23831ad82a10e51a7837d2
https://pubmed.ncbi.nlm.nih.gov/35948399
https://pubmed.ncbi.nlm.nih.gov/35948399
Autor:
Thomas N. Burn, Craig H. Bassing, Megan R. Fisher, Kyutae D. Lee, Noor Dawany, Tanner F. Robertson, Edward M. Behrens
Publikováno v:
ImmunoHorizons. 4(3)
The RAG1 and RAG2 proteins are essential for the assembly of Ag receptor genes in the process known as VDJ recombination, allowing for an immense diversity of lymphocyte Ag receptors. Congruent with their importance, RAG1 and RAG2 have been a focus o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c71db4001c3fe6b6d262826e8ea5e9
https://pubmed.ncbi.nlm.nih.gov/32144186
https://pubmed.ncbi.nlm.nih.gov/32144186