Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent

Autor: Daniel L. Minor, Paul Bessette, Thomas Mikita, Marco Lolicato, Kate L Lowe, Yun Cheol Kim, Jorge L. Garcia, Shaun R. Coughlin, Tovo David, Lauren Kate Ely, Dharmaraj Samuel

Publikováno v: Structure (London, England : 1993), vol 26, iss 2
Ely, Lauren K; Lolicato, Marco; David, Tovo; Lowe, Kate; Kim, Yun Cheol; Samuel, Dharmaraj; et al.(2018). Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent. STRUCTURE, 26(2), 187-+. doi: 10.1016/j.str.2017.12.010. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/7mk8c84v

Coagulation factor XIa is a candidate target for anticoagulants that better separate antithrombotic efficacy from bleeding risk. We report a co-crystal structure of the FXIa protease domain with DEF, a human monoclonal antibody that blocks FXIa funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46947f6b6305f22c5b0e05fbfd5ae245
https://doi.org/10.1016/j.str.2017.12.010

Synergistic Activation of the Germline ε Promoter Mediated by Stat6 and C/EBPβ

Autor: Thomas Mikita, Masae Kurama, Ulrike Schindler

Publikováno v: The Journal of Immunology. 161:1822-1828

Transcription of the Ig H chain germline transcripts is a prerequisite for class switching. Expression of the ε germline transcript is induced by IL-4 and requires the integrity of a composite IL-4 response element. The element is bound by the IL-4-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b2eb085e815648962443238ba6b4424
https://doi.org/10.4049/jimmunol.161.4.1822

Requirements for Interleukin-4-Induced Gene Expression and Functional Characterization of Stat6

Autor: K Williamson, Thomas Mikita, Ulrike Schindler, D Campbell, Pengguang Wu

Publikováno v: Molecular and Cellular Biology. 16:5811-5820

Interleukin-4 (IL-4) stimulation leads to the activation of the signal transducer and activator of transcription 6 (Stat6). In this study, we present data relating to the functional properties of Stat6. Human embryonic kidney 293 cells were shown to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8535a8921fcf53e75aa83d361d587f9b
https://doi.org/10.1128/mcb.16.10.5811

Oxidized low density lipoprotein exposure alters the transcriptional response of macrophages to inflammatory stimulus

Autor: Thomas Mikita, Gordon Porter, Dov Shiffman, Richard M. Lawn

Publikováno v: The Journal of biological chemistry. 276(49)

Macrophage-derived foam cells in atherosclerotic lesions are generally thought to play a major role in the pathology of the disease. Because macrophages play a central role in the inflammatory response, and the atherosclerotic lesion has features ass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::298d8323514602be36400c91e9b1f856
https://pubmed.ncbi.nlm.nih.gov/11577090

Effects of arabinosylcytosine-substituted DNA on DNA/RNA hybrid stability and transcription by T7 RNA polymerase

Autor: Thomas Mikita, Beardsley Gp

Publikováno v: Biochemistry. 33(31)

Cytosine arabinoside (araC) is a potent antileukemic agent which interferes with DNA replication both as a dNTP competitive inhibitor as well as after its misincorporation into DNA. We previously developed a chemical methodology for the synthesis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadde198446dddb7eed671de6c09a9e9
https://pubmed.ncbi.nlm.nih.gov/7519442