Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks

Autor: Jean Lesne, Marie Locard-Paulet, Julien Parra, Dušan Zivković, Thomas Menneteau, Marie-Pierre Bousquet, Odile Burlet-Schiltz, Julien Marcoux

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

Immune cells express immunoproteasomes (i20S), which bind to specialized regulators, contain different catalytic subunits and generate immunogenic peptides. HDX-MS—based assessment of the differences between the conformational dynamics of standard

Externí odkaz: https://doaj.org/article/ed5d484ebb094784a4e9cc4583e3d0aa

Comparison of label-free quantification methods for the determination of protein complexes subunits stoichiometry

Autor: Bertrand Fabre, Thomas Lambour, David Bouyssié, Thomas Menneteau, Bernard Monsarrat, Odile Burlet-Schiltz, Marie-Pierre Bousquet-Dubouch

Publikováno v: EuPA Open Proteomics, Vol 4, Iss C, Pp 82-86 (2014)

Protein complexes are the main molecular machines that support all major cellular pathways and their in-depth characterization are essential to understand their functions. Determining the stoichiometry of the different subunits of a protein complex s

Externí odkaz: https://doaj.org/article/9bc5fa69dc2c4335862f40452110f3d5

Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis

Autor: Sandrine Lise, Adrien Schahl, Christine Kervarrec, Paula C. A. da Fonseca, Charles Pineau, Matthieu Chavent, Angelique Sanchez Dafun, Marie-Pierre Bousquet, Julien Marcoux, Odile Burlet-Schiltz, Thomas Menneteau, Dušan Živković, Ana Toste Rêgo

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (15), pp.e2116826119. ⟨10.1073/pnas.2116826119⟩

During spermatogenesis, spermatogonia undergo a series of mitotic and meiotic divisions on their path to spermatozoa. To achieve this, a succession of complex processes requiring high proteolytic activity are in part orchestrated by the proteasome. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae01513020df7bfdc6674833f2badda7
https://hal.science/hal-03396712

C02 FAN1 controls cag repeat expansion in huntington’s disease by dual functions, MLH1 retention and nuclease activity

Autor: Hilary Wilkinson, Konstantinos Thalassinos, Emma L. Bunting, Gillian P. Bates, Antonio Porro, Thomas Menneteau, Jose R. Vicente, Robert Goold, Michael Flower, Joseph Hamilton, Alessandro A. Sartori, Gabriel Balmus, Sarah Aldous, Sarah J. Tabrizi, Nicholas D. Allen

Publikováno v: C: Genetic modifiers.

Background Human genetic studies have shown that, after CAG repeat length, DNA maintenance is the main process influencing Huntington’s disease (HD) pathogenesis. This likely acts via somatic expansion - a process in which the pathogenic CAG repeat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12845b7a37deff33fa310b5b5cb4111d
https://doi.org/10.1136/jnnp-2021-ehdn.26

Software Requirements for the Analysis and Interpretation of Native Ion Mobility Mass Spectrometry Data

Autor: Frank Sobott, Perdita E. Barran, Argyris Politis, Thomas Menneteau, Sarah Cianférani, Valérie Gabelica, Rita Grandori, Justin L. P. Benesch, Lukasz G. Migas, Matteo T. Degiacomi, Konstantinos Thalassinos, Michal Sharon, Timothy M. Allison, Erik G. Marklund

Publikováno v: Analytical chemistry, 2020, Vol.92(16), pp.10881-10890 [Peer Reviewed Journal]
Analytical chemistry
Analytical Chemistry
Analytical Chemistry, American Chemical Society, 2020, 92 (16), pp.10881-10890. ⟨10.1021/acs.analchem.9b05792⟩
Allison, T M, Barran, P, Benesch, J L P, Cianferani, S, Degiacomi, M T, Gabelica, V, Grandori, R, Marklund, E G, Menneteau, T, Migas, L G, Politis, A, Sharon, M, Sobott, F & Thalassinos, K 2020, ' Software Requirements for the Analysis and Interpretation of Native Ion Mobility Mass Spectrometry Data ', Analytical Chemistry, vol. 92, no. 16, pp. 10881-10890 . https://doi.org/10.1021/acs.analchem.9b05792

The past few years have seen a dramatic increase in applications of native mass and ion mobility spectrometry, especially for the study of proteins and protein complexes. This increase has been catalyzed by the availability of commercial instrumentat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbfadd05375b4b68467935ac22876a1
https://pubmed.ncbi.nlm.nih.gov/32649184