Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Thomas Melendy"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4540 (2024)
Polyomavirus (PyV) Large T-antigen (LT) is the major viral regulatory protein that targets numerous cellular pathways for cellular transformation and viral replication. LT directly recruits the cellular replication factors involved in initiation of v
Externí odkaz:
https://doaj.org/article/4572d874e74841b5a6b653735ce5efc0
Autor:
Jeffrey C. Martin, Jennie R. Sims, Ajay Gupta, Tamara J. Hagoel, Lingqiu Gao, Miranda L. Lynch, Anna Woloszynska, Thomas Melendy, Jeremy F. Kane, Joseph Kuechle, Joyce E. Ohm
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Ewing sarcoma is the second most common bone malignancy in children and adolescents. In recent years, a large body of evidence has emerged that suggests Ewing tumors harbor large amounts of replication stress (RS). CDC7, also known as DDK (D
Externí odkaz:
https://doaj.org/article/2a7eb0001dd44a14a8ad4db3dab0f299
Autor:
Justin Zonneville, Moyi Wang, Mohammed M. Alruwaili, Brandon Smith, Megan Melnick, Kevin H. Eng, Thomas Melendy, Ben Ho Park, Renuka Iyer, Christos Fountzilas, Andrei V. Bakin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Zonneville et al. show that p53 mutant cancers express high levels of the Base Excision Repair (BER) pathway and that deoxyuridine analogues induce DNA damage in p53-mutant TNBC cells. They exploit this genetic liability for therapeutic purposes usin
Externí odkaz:
https://doaj.org/article/82a83cc457434b04a6a0abf6527d94ee
Autor:
Amogh Gopinathan Nair, Nick Rabas, Sara Lejon, Caleb Homiski, Michael J. Osborne, Normand Cyr, Aleksandr Sverzhinsky, Thomas Melendy, John M. Pascal, Ernest D. Laue, Katherine L. B. Borden, James G. Omichinski, Alain Verreault
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11099 (2022)
The eukaryotic DNA replication fork is a hub of enzymes that continuously act to synthesize DNA, propagate DNA methylation and other epigenetic marks, perform quality control, repair nascent DNA, and package this DNA into chromatin. Many of the enzym
Externí odkaz:
https://doaj.org/article/2e59bc152815426e9ca923121e0e3f23
Autor:
Mohammed Alruwaili, Justin Zonneville, Hannah Serio, Thomas Melendy, Robert Straubinger, Bryan Gillard, Barbara A. Foster, Priyanka Rajan, Sarah Chatley, Renuka Iyer, Christos Fountzilas, Andrei V. Bakin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdc8318377c26c811fa9df87b92659b4
https://doi.org/10.2139/ssrn.4412635
https://doi.org/10.2139/ssrn.4412635
Autor:
Michaelle Chojnacki, Thomas Melendy
Publikováno v:
Viruses, Vol 10, Iss 6, p 321 (2018)
The papillomavirus (PV) protein E2 is one of only two proteins required for viral DNA replication. E2 is the viral transcriptional regulator/activation protein as well as the initiator of viral DNA replication. E2 is known to interact with various ce
Externí odkaz:
https://doaj.org/article/422420e2e72a4865a9399f8702e1689f
Autor:
Tamara J. Hagoel, Jeremy Kane, Anna Woloszynska, Thomas Melendy, Joyce E. Ohm, Jeffrey C Martin, Lingui Gao, Joseph Kuechle, Ajay Gupta, Miranda L. Lynch
Ewing sarcoma is the second most common bone malignancy in children and adolescents. Patients with upfront metastatic or recurrent disease have poor outcomes with 5-year survival rates of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50b378d08796f6e6e1915d1cc08fbf5f
https://doi.org/10.1101/2021.11.02.466939
https://doi.org/10.1101/2021.11.02.466939
Publikováno v:
Drug Discovery Today
ChemRxiv
ChemRxiv
In this manuscript we highlight consensus between the list of drugs currently in clinical trials to treat COVID-19, the worldwide pandemic caused by severe acute respiratory coronavirus 2 (SARS-CoV-2), and the list of predictions made using our shotg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1061ef1504452edcbd1121b35e17b2
https://doi.org/10.1016/j.drudis.2020.05.002
https://doi.org/10.1016/j.drudis.2020.05.002
Autor:
Thomas Melendy, Justin Zonneville, Andrei V. Bakin, Christos Fountzilas, Kevin H. Eng, Moyi Wang, Ben Ho Park, Mohammed M. Alruwaili, Renuka Iyer
Publikováno v:
Cancer Research. 81:1180-1180
Breast carcinomas commonly carry mutations in the tumor suppressor p53, while therapeutic efforts to target mutant p53 were largely unfruitful. Here we present preclinical data supporting a novel combination therapy strategy for treatment of p53-defi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::146b07af24abb6d5ad384b3d5ab898d6
https://doi.org/10.1158/1538-7445.am2021-1180
https://doi.org/10.1158/1538-7445.am2021-1180
Autor:
Mohammed M. Alruwaili, Moyi Wang, Thomas Melendy, Renuka Iyer, Kevin H. Eng, Justin Zonneville, Megan Melnick, Ben Ho Park, Brandon E. Smith, Christos Fountzilas, Andrei V. Bakin
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Breast carcinomas commonly carry mutations in the tumor suppressor p53, although therapeutic efforts to target mutant p53 have previously been unfruitful. Here we report a selective combination therapy strategy for treatment of p53 mutant cancers. Ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89218a5d4fba77e03d9ddf4fdee583ca
https://pubmed.ncbi.nlm.nih.gov/34253820
https://pubmed.ncbi.nlm.nih.gov/34253820