Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Thomas McDonnell"'
Autor:
Thomas McDonnell, Joshua Storrar, Rajkumar Chinnadurai, Calvin Heal, Constantina Chrysochou, James Ritchie, Francesco Rainone, Dimitrios Poulikakos, Philip Kalra, Smeeta Sinha
Publikováno v:
BMC Nephrology, Vol 24, Iss 1, Pp 1-10 (2023)
Abstract Introduction Focal segmental glomerulosclerosis (FSGS) is one of the leading causes of nephrotic syndrome in adults. This epidemiological study describes a renal centre’s 20-year experience of primary FSGS. Methods Patients were identified
Externí odkaz:
https://doaj.org/article/70f6e802c85c49eaa88d8c104c56d2dc
Autor:
Barry Shaw, Thomas McDonnell, Elizabeth Radley, Brian Thomas, Lynn Smith, Carol A.L. Davenport, Silvia Gonzalez, Anisur Rahman, Rob Layfield
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107575- (2023)
Summary: Archaeological remains can preserve some proteins into deep time, offering remarkable opportunities for probing past events in human history. Recovering functional proteins from skeletal tissues could uncover a molecular memory related to th
Externí odkaz:
https://doaj.org/article/d1e8ba3c540f4d5ebc737782fd9b8f1c
Autor:
Thomas McDonnell, John Hartemink, Omar Ragy, Kathrine Parker, Meshaal Shukkur, Jecko Thachil, Durga Kanigicherla
Publikováno v:
Glomerular Diseases, Pp 1-1 (2023)
Introduction Thromboembolic events (TEEs) are a serious and potentially fatal complication of nephrotic syndrome (NS). Despite this there is a lack of evidence examining the benefits of prophylactic anticoagulation (PAC) in NS. It was our objective t
Externí odkaz:
https://doaj.org/article/42d12bce607a41069dff9b5e4aaad2c8
Autor:
Anisur Rahman, Ian Giles, Chris Wincup, Bahar Artim-Esen, Thomas McDonnell, Charis Pericleous, Raj Amarnani, Ian Mackie, Carina Spicer, Hajar Jbari, Valentina A Spiteri
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss 1 (2022)
Objectives The significance of antibodies directed against activated factor X (FXa) and thrombin (Thr) in patients with SLE and/or antiphospholipid syndrome (APS) is unknown. FXa and Thr are coregulated by antithrombin (AT) and activate complement. T
Externí odkaz:
https://doaj.org/article/785035e9ebeb4c33b2e29ad930994361
Autor:
Ina Buchholz, Thomas McDonnell, Peter Nestler, Sudarat Tharad, Martin Kulke, Anna Radziszewska, Vera M. Ripoll, Frank Schmidt, Elke Hammer, Jose L. Toca-Herrera, Anisur Rahman, Mihaela Delcea
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Beta-2-glycoprotein I (β2GPI) is a blood protein and the major antigen in the autoimmune disorder antiphospholipid syndrome (APS). β2GPI exists mainly in closed or open conformations and comprises of 11 disulfides distributed across five d
Externí odkaz:
https://doaj.org/article/ab52dc10ebec4e0c9e466f4231064c67
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1153 (2023)
The number of people living with chronic kidney disease (CKD) is growing as our global population continues to expand. With aging, diabetes, and cardiovascular disease being major harbingers of kidney disease, the number of people diagnosed with diab
Externí odkaz:
https://doaj.org/article/0c3f54a13803487f9735acfb7fe39e1d
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 926 (2023)
There is an increased incidence of elderly adults diagnosed with kidney failure as our global aging population continues to expand. Hence, the number of elderly adults indicated for kidney replacement therapy is also increasing simultaneously. Haemod
Externí odkaz:
https://doaj.org/article/ad22b32cf64f4ca98a9b681b364c4550
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Chronic inflammatory placental disorders are a group of rare but devastating gestational syndromes associated with adverse pregnancy outcome. This review focuses on three related conditions: villitis of unknown etiology (VUE), chronic histiocytic int
Externí odkaz:
https://doaj.org/article/602cdda6e93544a4bd18ebd6bf3a3f50
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Immunological adaptations in pregnancy allow maternal tolerance of the semi-allogeneic fetus but also increase maternal susceptibility to infection. At implantation, the endometrial stroma, glands, arteries and immune cells undergo anatomical and fun
Externí odkaz:
https://doaj.org/article/8fd6dad1c492485fb14d7d2dcb50338d
Autor:
Thomas McDonnell, Bahar Artim-Esen, Chris Wincup, Vera M. Ripoll, David Isenberg, Ian P. Giles, Anisur Rahman, Charis Pericleous
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Antiphospholipid antibodies (aPL), the serological hallmark of antiphospholipid syndrome (APS), are a heterogeneous group of autoantibodies raised against circulating blood proteins. Of these proteins, the phospholipid-binding b2-glycoprotein I (β2G
Externí odkaz:
https://doaj.org/article/0ece953eefd0478c872233844c9d1904