Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Thomas Martinson"'
Autor:
Blandine Franke-Fayard, Catherin Marin-Mogollon, Fiona J. A. Geurten, Séverine Chevalley-Maurel, Jai Ramesar, Hans Kroeze, Els Baalbergen, Els Wessels, Ludivine Baron, Valérie Soulard, Thomas Martinson, Maya Aleshnick, Antonius T. G. Huijs, Amit K. Subudhi, Yukiko Miyazaki, Ahmad Syibli Othman, Surendra Kumar Kolli, Olivia A. C. Lamers, Magali Roques, Rebecca R. Stanway, Sean C. Murphy, Lander Foquet, Diana Moita, António M. Mendes, Miguel Prudêncio, Koen J. Dechering, Volker T. Heussler, Arnab Pain, Brandon K. Wilder, Meta Roestenberg, Chris J. Janse
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-17 (2022)
Abstract Whole-sporozoite (WSp) malaria vaccines induce protective immune responses in animal malaria models and in humans. A recent clinical trial with a WSp vaccine comprising genetically attenuated parasites (GAP) which arrest growth early in the
Externí odkaz:
https://doaj.org/article/588f50a437454e409cd5b77f93854c95
Autor:
Erika L. Flannery, Niwat Kangwanrangsan, Vorada Chuenchob, Wanlapa Roobsoong, Matthew Fishbaugher, Kevin Zhou, Zachary P. Billman, Thomas Martinson, Tayla M. Olsen, Carola Schäfer, Brice Campo, Sean C. Murphy, Sebastian A. Mikolajczak, Stefan H.I. Kappe, Jetsumon Sattabongkot
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 427-440 (2022)
Plasmodium vivax is a malaria-causing pathogen that establishes a dormant form in the liver (the hypnozoite), which can activate weeks, months, or years after the primary infection to cause a relapse, characterized by secondary blood-stage infection.
Externí odkaz:
https://doaj.org/article/3f99df60d3ce4a3b823a1cfa275feab1
Autor:
Nana K. Minkah, Brandon K. Wilder, Amina A. Sheikh, Thomas Martinson, Lisa Wegmair, Ashley M. Vaughan, Stefan H. I. Kappe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Here, Minkah et al. show that, while immunization with replication-competent Plasmodium parasites can confer sterile protection against infection, it also induces a type I interferon response that adversely affects anti-malaria immunity by affecting
Externí odkaz:
https://doaj.org/article/4803ab594660449eb646c58a1da8b3d4
Autor:
Martin J. Smilkstein, Sovitj Pou, Alina Krollenbrock, Lisa A. Bleyle, Rozalia A. Dodean, Lisa Frueh, David J. Hinrichs, Yuexin Li, Thomas Martinson, Myrna Y. Munar, Rolf W. Winter, Igor Bruzual, Samantha Whiteside, Aaron Nilsen, Dennis R. Koop, Jane X. Kelly, Stefan H. I. Kappe, Brandon K. Wilder, Michael K. Riscoe
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-17 (2019)
Abstract Background The potential benefits of long-acting injectable chemoprotection (LAI-C) against malaria have been recently recognized, prompting a call for suitable candidate drugs to help meet this need. On the basis of its known pharmacodynami
Externí odkaz:
https://doaj.org/article/630a94e7fc5a4c469f0ed0eacdad2650
Autor:
Silvia A. Arredondo, Kristian E. Swearingen, Thomas Martinson, Ryan Steel, Dorender A. Dankwa, Anke Harupa, Nelly Camargo, William Betz, Vladimir Vigdorovich, Brian G. Oliver, Niwat Kangwanrangsan, Tomoko Ishino, Noah Sather, Sebastian Mikolajczak, Ashley M. Vaughan, Motomi Torii, Robert L. Moritz, Stefan H. I. Kappe
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Within the liver, Plasmodium sporozoites traverse cells searching for a “suitable” hepatocyte, invading these cells through a process that results in the formation of a parasitophorous vacuole (PV), within which the parasite undergoes intracellul
Externí odkaz:
https://doaj.org/article/4398165573ac4b7799ec59cf796a37f9
Publikováno v:
Molecular Therapy. 30:1810-1821
Monoclonal antibodies are highly specific proteins that are cloned from a single B cell and bind to a single epitope on a pathogen. These laboratory-made molecules can serve as prophylactics or therapeutics for infectious diseases and have an impress
Autor:
Lisa Wegmair, Nana K. Minkah, Thomas Martinson, Stefan H. I. Kappe, Amina A. Sheikh, Brandon K. Wilder, Ashley M. Vaughan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Immunization with attenuated whole Plasmodium sporozoites constitutes a promising vaccination strategy. Compared to replication-deficient parasites, immunization with replication-competent parasites confers better protection and also induces a type I
Publikováno v:
Veterinary Microbiology. 230:273-277
Mycoplasma hyorhinis (Mhr) is a pathogen of pigs causing polyserositis and polyarthritis. The most susceptible population are nursery pigs of approximately 7 weeks of age, although we have shown that clinical signs can persist into finishing aged ani
Autor:
Brandon Keith Wilder, Luna de Lacerda, Camila R. R. Barbosa, Maya Aleshnick, Thomas Martinson, David Morrow, Zeshou Zhao, Gaurav Gaiha, Caroline Junqueira
Publikováno v:
The Journal of Immunology. 208:170.27-170.27
CD8 T cells have long been known to target infected hepatocytes during the intracellular liver stages of Plasmodium—the causative agent of malaria. Current T cell vaccine strategies are limited by the inability to obtain sufficient amounts of Plasm
Autor:
Aaron Nilsen, Thomas Martinson, Alina Krollenbrock, Lisa Frueh, Lisa Bleyle, Rozalia Dodean, Samantha Whiteside, Igor Bruzual, David J. Hinrichs, Dennis R. Koop, Stefan H. I. Kappe, Sovitj Pou, Michael K. Riscoe, Jane Xu Kelly, Martin J. Smilkstein, Myrna Y. Munar, Rolf W. Winter, Yuexin Li, Brandon K. Wilder
Publikováno v:
Malaria Journal
Malaria Journal, Vol 18, Iss 1, Pp 1-17 (2019)
Malaria Journal, Vol 18, Iss 1, Pp 1-17 (2019)
BackgroundThe potential benefits of long-acting injectable chemoprotection (LAI-C) against malaria have been recently recognized, prompting a call for suitable candidate drugs to help meet this need. On the basis of its known pharmacodynamic and phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e9df3dea5dabbdc535615107019ec2