Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Thomas Martin Krulle"'
The synthesis of d -mannuronolactone acetonide 1 is described from alginic acid and provides an efficient route for the manipulation at C-5 of mannose. Reduction gives a new acetonide of mannose, 1,2-O- isopropylidene-β- d -mannofuranose which, on f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920a9eef442f4f16b480795f186e530f
https://ora.ox.ac.uk/objects/uuid:c4e724e8-08ec-4290-a933-85c9a0bba1e7
https://ora.ox.ac.uk/objects/uuid:c4e724e8-08ec-4290-a933-85c9a0bba1e7
Autor:
Mary Gregoriou, Carmen de la Fuente, Katerina E. Tsitsanou, Louise N. Johnson, Nikos G. Oikonomakos, K.A. Watson, Thomas Martin Krulle, George W. J. Fleet, Spyros E. Zographos
Publikováno v:
Synlett 2(Feb1997):211-213
Journal URL: http://www.thieme-connect.com/ejournals/toc/synlett
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad68b061b0a97a76ae66ffe44728b72
https://ora.ox.ac.uk/objects/uuid:f14027a0-3507-465d-8027-631f3c47a4b7
https://ora.ox.ac.uk/objects/uuid:f14027a0-3507-465d-8027-631f3c47a4b7
Autor:
David A. Scott, Terry D. Butters, Ana L. Winters, Robert J. Nash, Thomas Martin Krulle, Malcolm Finn, Naoki Asano, George W. J. Fleet
Reductive amination of dihydroxyacetone by ammonium salts with sodium cyanoborohydride gives bis(1,3-dihydroxy-isopropyl)amine [BDI] in good yield and high purity. BDI and its diacetonide are hindered nucleophiles but may be further reductively alkyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d359e24bdda4f57050a841541d697c7
https://ora.ox.ac.uk/objects/uuid:0483cd63-b5de-4e01-b8b4-9e2db99b4268
https://ora.ox.ac.uk/objects/uuid:0483cd63-b5de-4e01-b8b4-9e2db99b4268
Autor:
George W. J. Fleet, David R. Brown, Helen Ardron, Thomas Martin Krulle, Benjamin L. Davis, Neil A. Hindle, Daniel G. Marquess, Daniel D. Long, Alexandra L. Lane, Colin Smith, David J. Watkin
Displacement of α-triflates of 2,3,4-all cis-substituted γ-lactones by sodium azide in DMF gives kinetically an azide with inversion of configuration at the C-2 of the lactone; under the reaction conditions, the initially formed azide epimerises to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7bc39733cd0fa1b2dcadbfade593f7
https://doi.org/10.1039/cc9960001271
https://doi.org/10.1039/cc9960001271
Autor:
George W. J. Fleet, Thomas Martin Krulle, Naoki Asano, Raymond A. Dwek, Dirk Gretzke, Yves Blériot, Robert J. Nash, Terry D. Butters
1,6-Dideoxygalactostatin, the mirror image of 1-deoxy-L-fuconojirimycin, was efficiently prepared from 2,3-O-isopropylidene-L-lyxonolactone in four steps and evaluated as a glycosidase inhibitor. © 2005 Elsevier Ltd. All rights reserved.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f181d4a43bb60a29c7b854f5494de1f
https://doi.org/10.1016/j.carres.2005.10.002
https://doi.org/10.1016/j.carres.2005.10.002
Autor:
Adam J. Babbs, Daniel Provost, James G. McCormack, Rosemary E. Chatfield, Thomas Martin Krulle, Peter S. Widdowson, Gerard Hugh Thomas
Publikováno v:
Obesity. 17:467-473
The noradrenaline (NA) and serotonin reuptake inhibitor, sibutramine, gives effective weight loss, but full efficacy cannot be attained at approved doses due to cardiovascular side effects. We assessed in rats the contributions of NA and serotonin tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9345e09c6ebe436cd27bfe88f19a209c
https://doi.org/10.1038/oby.2008.550
https://doi.org/10.1038/oby.2008.550
Publikováno v:
Tetrahedron Letters. 41:3959-3962
Bis(1,3-dihydroxy-isopropyl)amine (BDI)1, a symmetrical AB4 dendritic building block, is developed into two diamine linkers in which the nitrogen is more nucleophilic. The four primary alcohols in BDI undergo Michael reactions with t-butyl acrylate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d64e96e40bfcf2cb1312e8547a5777
https://doi.org/10.1016/s0040-4039(00)00487-1
https://doi.org/10.1016/s0040-4039(00)00487-1
Autor:
Mary Gregoriou, George W. J. Fleet, Kimberly A. Watson, Louise N. Johnson, Elspeth F. Garman, Martin E.M. Noble, N.G. Oikonomakos, Thomas Martin Krulle, C. De La Fuente
Publikováno v:
Protein Science. 7:915-927
A glucopyranose spirohydantoin (a pyranose analogue of the potent herbicide, hydantocidin) has been identified as the highest affinity glucose analogue inhibitor of glycogen phosphorylase b (GPb). In order to elucidate the structural features that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07154ea10519e83936f8182acd5455d0
https://doi.org/10.1002/pro.5560070409
https://doi.org/10.1002/pro.5560070409
Publikováno v:
Organic letters. 12(12)
An efficient total synthesis of the novel botryococcene-related hydrocarbon 7,11-cyclobotryococca-5,12,26-triene is reported that uses, as a key step, an oxidative radical cyclization of a 4-pentenyl malonate for the synthesis of a [3.3.0]-bicyclic g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3761e48e5864516cbb617d9dd0041c
https://pubmed.ncbi.nlm.nih.gov/20481483
https://pubmed.ncbi.nlm.nih.gov/20481483
Autor:
Rhodri C. Griffiths, Carmen de la Fuente, Spyros E. Zographos, Katerina E. Tsitsanou, Nikos G. Oikonomakos, George W. J. Fleet, Thomas Martin Krulle, Robert J. Nash, Lea Pickering, Robin T. Aplin
Publikováno v:
Tetrahedron: Asymmetry 8:22(Nov1997):3807-3820
Scopus-Elsevier
Scopus-Elsevier
Triazole-carboxylic acids related to d -glucose and d -galactose may be prepared by intramolecular [1,3]-dipolar cycloadditions of azides to unsaturated esters, followed by bromine oxidation of the resulting triazoline. Such materials may provide a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e57544f94787ff056d328091e20be3
http://helios-eie.ekt.gr/EIE/handle/10442/2945
http://helios-eie.ekt.gr/EIE/handle/10442/2945