Výsledky vyhledávání - "Thomas Mariannino"

UHPLC–MS/MS bioanalysis of human plasma coproporphyrins as potential biomarkers for organic anion-transporting polypeptide-mediated drug interactions

Autor: Rasa Santockyte, Thomas Mariannino, Richard Burrrell, Hamza Kandoussi, Patricia Paterson, Pathanjali Kadiyala, Hong Shen, Jianing Zeng, Kumar Shah, Yan Zhang, Punit Marathe, Petia Shipkova, Renuka Pillutla, Yurong Lai, John A. Easter, Robert Langish

Publikováno v: Bioanalysis. 10:633-644

Aim: Coproporphyrins (CP-I and CP-III) have been identified as possible biomarkers to predict human hepatic organic anion-transporting polypeptides-mediated-drug-interactions for a new drug entering clinical development. Results: The method is applic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c0e3a11a3e78851f3e18021f180eb2
https://doi.org/10.4155/bio-2017-0246

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Liquid chromatography and tandem mass spectrometry for the quantitative determination of ixabepilone (BMS-247550, Ixempra™) in human plasma: Method validation, overcoming curve splitting issues and eliminating chromatographic interferences from degradants

Autor: William Mylott, James Waltrip, Lisa Iacono, Jianing Zeng, Xiaohui Xu, Thomas Mariannino, Bruce Stouffer, Mark E. Arnold

Publikováno v: Journal of Chromatography B. 878:525-537

A sensitive method was developed and validated for the measurement of ixabepilone (BMS-247550, Ixempra) using a demethylated analogue of ixabepilone (BMS-212188) as an internal standard. A 0.050 mL portion of each plasma sample was extracted with 0.4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaffc8c67e9e6589c17a001ee3b2f0f1
https://doi.org/10.1016/j.jchromb.2009.12.014

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A validated HPLC-MS/MS assay for quantifying unstable pharmacologically active metabolites of clopidogrel in human plasma: application to a clinical pharmacokinetic study

Autor: Thomas Mariannino, Ishani Savant, William Mylott, Michael T. Furlong, Mark E. Arnold, Laura Scott, Vikram Roongta, Pathanjali Kadiyala, Moucun Yuan

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 926

Clopidogrel is prescribed for the treatment of Acute Coronary Syndrome and recent myocardial infarction, recent stroke, or established peripheral arterial disease. A sensitive and reliable high performance liquid chromatography-tandem mass spectromet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7551d34326536581327d4dd426dbfe4
https://pubmed.ncbi.nlm.nih.gov/23542721

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A validated enantioselective LC-MS/MS assay for the simultaneous determination of carvedilol and its pharmacologically active 4'-hydroxyphenyl metabolite in human plasma: application to a clinical pharmacokinetic study

Autor: Thomas Mariannino, Michael T. Furlong, Bruce Stouffer, Song Zhao, William Mylott, Jim X Shen, Bing He

Publikováno v: Journal of pharmaceutical and biomedical analysis. 70

Carvedilol is widely prescribed for the treatment of hypertension, heart failure and left ventricular dysfunction following myocardial infarction. A sensitive and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay was developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f53aef247ec9528d2ca138c169e6358
https://pubmed.ncbi.nlm.nih.gov/22709607

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