Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Thomas Maciag"'
Autor:
Maria F. Duarte, Joseph M. Verdi, Igor Prudovsky, George N. Nikopoulos, Thomas Maciag, Robert Friesel, Chris J. Kubu, Stephen Bellum
Publikováno v:
Stem Cells. 25:3133-3142
The activation of Notch signaling in neural crest stem cells (NCSCs) results in the rapid loss of neurogenic potential and differentiation into glia. We now show that the attenuation of endogenous Notch signaling within expanding NCSC clones by the N
Autor:
Michael Simons, Dmitri V. Baklanov, Karen L Moodie, F. Redican, Zhen W. Zhuang, Volkhard Lindner, Anna Mandinova, E D de Muinck, Thomas Maciag, Lazar Mandinov
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 291:H2692-H2697
Stress-induced release of IL-1α and fibroblast growth factor-1 is dependent on intracellular copper and is a major driver of neointimal hyperplasia. Therefore, we assessed the effect of tetrathiomolybdate (TTM), a clinically proven copper chelator,
Autor:
Vihren Kolev, Igor Prudovsky, Robert Friesel, Maria F. Duarte, Thomas Maciag, Silvia Marta Oliveira, Irene Graziani, Doreen Kacer, Alexander Kirov, Raffaella Soldi
Publikováno v:
Biochemical and Biophysical Research Communications. 350:604-609
Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release fr
Autor:
Thomas Maciag, Vihren Kolev, Olga Sideleva, Igor Prudovsky, Irene Graziani, Barry W. Larman, Doreen Kacer, Radianna Trifonova, Maria F. Duarte, Raffaella Soldi, Deena Small
Publikováno v:
FEBS Letters. 579:5798-5802
Notch signaling involves proteolytic cleavage of the transmembrane Notch receptor after binding to its transmembrane ligands, Delta or Jagged; and the resultant soluble intracellular domain of Notch stimulates a cascade of transcriptional events. The
Autor:
Dimitry Kovalenko, Raffaella Soldi, Vihren Kolev, Deena Small, Radianna Trifonova, Anna Mandinova, Lucy Liaw, Doreen Kacer, Thomas Maciag, Igor Prudovsky
Publikováno v:
Journal of Biological Chemistry. 279:13285-13288
The interactions between Notch (N) receptors and their transmembrane ligands, Jagged1 (JI) and Delta1 (Dl1), mediate signaling events between neighboring cells that are crucial during embryonal development and in adults. Since the non-transmembrane e
Autor:
Igor Prudovsky, Francesca Tarantini, Cinzia Bagalà, Thomas Maciag, Irene Graziani, Anna Mandinova, Raffaella Soldi, Stephen Bellum, Maria F. Duarte, Matteo Landriscina, Holly Doherty
Publikováno v:
Journal of Cell Science. 116:4871-4881
Non-classical protein release independent of the ER-Golgi pathway has been reported for an increasing number of proteins lacking an N-terminal signal sequence. The export of FGF1 and IL-1α, two pro-angiogenic polypeptides, provides two such examples
Autor:
Igor Prudovsky, Stephen Bellum, Francesca Tarantini, Cinzia Bagalà, Anna Mandinova, Thomas Maciag, Raffaella Soldi
Publikováno v:
The Journal of Cell Biology
The release of signal peptideless proteins occurs through nonclassical export pathways and the release of fibroblast growth factor (FGF)1 in response to cellular stress is well documented. Although biochemical evidence suggests that the formation of
Publikováno v:
The American Journal of Pathology. 159:875-883
The Jagged/Notch signaling pathways control cell fate determination and differentiation, and their dysfunction is associated with human pathologies involving cardiovascular abnormalities. To determine the presence of these genes during vascular respo
Autor:
Francesca Tarantini, Thomas Maciag, Isabella Micucci, Igor Prudovsky, Stephen Bellum, Matteo Landriscina, Susan Garfinkel
Publikováno v:
Journal of Biological Chemistry. 276:5147-5151
Interleukin (IL)1alpha mediates proinflammatory events through its extracellular interaction with the IL1 type I receptor. However, IL1alpha does not contain a conventional signal peptide sequence that provides access to the endoplasmic reticulum-Gol
Autor:
Thomas Maciag, Robert Friesel
Publikováno v:
Thrombosis and Haemostasis. 82:748-754
A Brief Introduction to the Fibroblast Growth Factor Gene Family The fibroblast growth factor (FGF) family of genes presently comprise 18 members, including the two prototypes, FGF-1 (acidic) and FGF-2 (basic). Although the FGF prototypes are well de