Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Thomas M. Vondriska"'
Autor:
Matthew A. Fischer, Adrian Arrieta, Marina Angelini, Elizabeth Soehalim, Douglas J. Chapski, Richard J. Shemin, Thomas M. Vondriska, Riccardo Olcese
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 12 (2024)
Externí odkaz:
https://doaj.org/article/7f4568f566094fb393f70bdb11fe5182
Autor:
Yang Cao, Laurent Vergnes, Yu-Chen Wang, Calvin Pan, Karthickeyan Chella Krishnan, Timothy M. Moore, Manuel Rosa-Garrido, Todd H. Kimball, Zhiqiang Zhou, Sarada Charugundla, Christoph D. Rau, Marcus M. Seldin, Jessica Wang, Yibin Wang, Thomas M. Vondriska, Karen Reue, Aldons J. Lusis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
In this paper, the authors show that sex differences in mitochondrial DNA levels and function in the heart contribute to sex biases in functions relevant to heart failure, identifying Acsl6 as a mitochondrial sex-biased regulator of diastolic functio
Externí odkaz:
https://doaj.org/article/89de6b77175046a88778990393d83932
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 3 (2023)
How chromatin accessibility and structure endow highly specialized cells with their unique phenotypes is an area of intense investigation. In the mammalian heart, an exclusive subset of cardiac cells comprise the conduction system. Many molecular com
Externí odkaz:
https://doaj.org/article/01b3adaad7d24b81b9cf4df78aa1b008
Autor:
Adrian Arrieta, Thomas M. Vondriska
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Maintenance of protein folding homeostasis, or proteostasis is critical for cell survival as well as for execution of cell type specific biological processes such as muscle cell contractility, neuronal synapse and memory formation, and cell transitio
Externí odkaz:
https://doaj.org/article/6f97887851af4a41acaa3dc496f9870e
Autor:
Adam D. Langenbacher, Fei Lu, Lauren Crisman, Zi Yi Stephanie Huang, Douglas J. Chapski, Thomas M. Vondriska, Yibin Wang, Chen Gao, Jau-Nian Chen
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 10, Iss 5, p 221 (2023)
The PAF1 complex component Rtf1 is an RNA Polymerase II-interacting transcription regulatory protein that promotes transcription elongation and the co-transcriptional monoubiquitination of histone 2B. Rtf1 plays an essential role in the specification
Externí odkaz:
https://doaj.org/article/2247b419ebec41f88a84da7d1beec553
Publikováno v:
Frontiers in Bioinformatics, Vol 2 (2022)
Recent advances in epigenomics measurements have resulted in a preponderance of genomic sequencing datasets that require focused analyses to discover mechanisms governing biological processes. In addition, multiple epigenomics experiments are typical
Externí odkaz:
https://doaj.org/article/1a8eb3bafe3c4532910499037ea50b3a
Autor:
Matthew A. Fischer, Aman Mahajan, Maximilian Cabaj, Todd H. Kimball, Marco Morselli, Elizabeth Soehalim, Douglas J. Chapski, Dennis Montoya, Colin P. Farrell, Jennifer Scovotti, Claudia T. Bueno, Naomi A. Mimila, Richard J. Shemin, David Elashoff, Matteo Pellegrini, Emma Monte, Thomas M. Vondriska
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia and post-operative atrial fibrillation (POAF) is a major healthcare burden, contributing to an increased risk of stroke, kidney failure, heart attack and death. Geneti
Externí odkaz:
https://doaj.org/article/d7d7b22b25d5424c99cc55fb3dc5f4de
Autor:
Arash Pezhouman, Ngoc B. Nguyen, Alexander J. Sercel, Thang L. Nguyen, Ali Daraei, Shan Sabri, Douglas J. Chapski, Melton Zheng, Alexander N. Patananan, Jason Ernst, Kathrin Plath, Thomas M. Vondriska, Michael A. Teitell, Reza Ardehali
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Background: Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) can be used as a source for cell delivery to remuscularize the heart after myocardial infarction. Despite their therapeutic potential, the emergence of ventricular arrhythmias ha
Externí odkaz:
https://doaj.org/article/b15067c9d27942a09f1c72c4d61693ac
Autor:
Noemí Cabré, Fedra Luciano-Mateo, Douglas J. Chapski, Gerard Baiges-Gaya, Salvador Fernández-Arroyo, Anna Hernández-Aguilera, Helena Castañé, Elisabet Rodríguez-Tomàs, Marta París, Fàtima Sabench, Daniel Del Castillo, Josep M. del Bas, Mercedes Tomé, Clément Bodineau, Alejandro Sola-García, José López-Miranda, Alejandro Martín-Montalvo, Raúl V. Durán, Thomas M. Vondriska, Manuel Rosa-Garrido, Jordi Camps, Javier A. Menéndez, Jorge Joven
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7830 (2022)
The surgically induced remission of liver disease represents a model to investigate the signalling processes that trigger the development of nonalcoholic steatohepatitis with the aim of identifying novel therapeutic targets. We recruited patients wit
Externí odkaz:
https://doaj.org/article/98b8b7e9308e419daf0a83b1afd3442c
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2019)
Packaging of the genome in the nucleus is a non-random process that is thought to directly contribute to cell type-specific transcriptomes, although this hypothesis remains untested. Epigenome architecture, as assayed by chromatin conformation captur
Externí odkaz:
https://doaj.org/article/5ccc51d259fd464a8f622895287fe280