Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Thomas M. Scherer"'
Autor:
Junyan A Ji, Y John Wang, Kai Zheng, Justin K Y Hong, Diya Ren, Wayne Lilyestrom, Thomas M. Scherer
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3952, p 3952 (2021)
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3952, p 3952 (2021)
Oxidation is an important degradation pathway of protein drugs. The susceptibility to oxidation is a common concern for therapeutic proteins as it may impact product efficacy and patient safety. In this work, we used 2,2′-azobis (2-amidinopropane)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d2d69f2f72850333e44c5e3c419abd
https://pubmed.ncbi.nlm.nih.gov/33921206
https://pubmed.ncbi.nlm.nih.gov/33921206
Publikováno v:
The Journal of Physical Chemistry B. 122:2138-2154
The question of how nonspecific reversible intermolecular protein interactions affect solution rheology at high concentrations is fundamentally rooted in the translation of nanometer-scale interactions into macroscopic properties. Well-defined soluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9dcd64869154982ee213f4bc389bf4
https://doi.org/10.1021/acs.jpcb.7b10728
https://doi.org/10.1021/acs.jpcb.7b10728
Autor:
Thomas M. Scherer
Publikováno v:
The Journal of Physical Chemistry B. 119:13027-13038
The solution thermodynamics and interactions of a reversibly self-associating monoclonal IgG1 antibody (mAb1) have been investigated as a function of cosolute type (NaCl, NaSCN, Arginine-HCl) and cosolute concentration over a wide range of protein co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9ec14ed4dfe57d8e2613f8d3bf093a
https://doi.org/10.1021/acs.jpcb.5b07568
https://doi.org/10.1021/acs.jpcb.5b07568
Autor:
Yun Liu, Eric J. Yearley, Thomas M. Scherer, Yatin R. Gokarn, Isidro E. Zarraga, Steven J. Shire, Norman J. Wagner
Publikováno v:
Biophysical Journal. 105(3):720-731
Small-angle neutron scattering (SANS) is used to probe the solution structure of two protein therapeutics (monoclonal antibodies 1 and 2 (MAb1 and MAb2)) and their protein-protein interaction (PPI) at high concentrations. These MAbs differ by small s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d7facbe3a26e50156f78918143e421
Autor:
Thomas M. Scherer, James Andya, Yatin R. Gokarn, Barthélemy Demeule, Sonoko Kanai, Sandeep Yadav, Steven J. Shire, Jun Liu
Publikováno v:
Biophysical Reviews. 5:121-136
Early development of protein biotherapeutics using recombinant DNA technology involved progress in the areas of cloning, screening, expression and recovery/purification. As the biotechnology industry matured, resulting in marketed products, a greater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1083b4459742be33a09046cf269ec649
https://doi.org/10.1007/s12551-013-0109-z
https://doi.org/10.1007/s12551-013-0109-z
Publikováno v:
The Journal of Physical Chemistry B. 116:9611-9618
Small-angle X-ray scattering experiments of two monoclonal antibodies (mAbs) were performed as a function of Hofmeister salt type and concentration including 100 mM Na(2)SO(4), 100-600 mM of NaSCN, or 100-600 mM arginine chloride at pH 6.0 to yield i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d4e476e0bccd37e9aa18bbdbaf859d
https://doi.org/10.1021/jp303839t
https://doi.org/10.1021/jp303839t
Publikováno v:
The AAPS Journal. 14:236-243
The analysis of particulates has been a longstanding challenge in biopharmaceutical drug product development and quality control because the active constituents themselves may form particulate matter as a degradation product that may be difficult to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8326cd907a1acd126677c89174e22bb
https://doi.org/10.1208/s12248-012-9335-8
https://doi.org/10.1208/s12248-012-9335-8
Autor:
Thomas M. Scherer, Boyan Zhang, Liangyi Zhang, Charlene Li, Wayne Lilyestrom, Robert van Reis
Publikováno v:
Analytical Chemistry. 83:8501-8508
During purification process development and analytical characterization, a recombinant human monoclonal antibody, referred to as rmAb1, showed an anomalous charge heterogeneity profile by cation-exchange chromatography (CIEC), characterized by extrem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25d49f5f03bfa1c73d499238d20f7d5
https://doi.org/10.1021/ac2016129
https://doi.org/10.1021/ac2016129
Publikováno v:
Analytical Biochemistry. 411:292-296
The present work discusses an alternative procedure to obtain static light scattering (SLS) parameters in a dilute and semidilute concentration regime from a dynamic light scattering (DLS) instrument that uses an avalanche photodiode (APD) for record
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8167089269a4aa9f1b4d579d8b64ccbc
https://doi.org/10.1016/j.ab.2010.12.014
https://doi.org/10.1016/j.ab.2010.12.014
Autor:
Thomas M. Scherer, Steven J. Shire
Publikováno v:
Mucosal Delivery of Biopharmaceuticals ISBN: 9781461495239
This review summarizes the development of rhDNase as a pharmaceutical for pulmonary delivery including development and stability assessment of a formulation, compatibility with jet nebulization, characterization of the aerosols produced by jet nebuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d4822179b88503f24db689dd69d2806
https://doi.org/10.1007/978-1-4614-9524-6_20
https://doi.org/10.1007/978-1-4614-9524-6_20
