Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Thomas M. Sanderson"'
Autor:
Yana Van Den Herrewegen, Thomas M. Sanderson, Surajit Sahu, Dimitri De Bundel, Zuner A. Bortolotto, Ilse Smolders
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-13 (2021)
Abstract Astrocytes express a plethora of G protein-coupled receptors (GPCRs) that are crucial for shaping synaptic activity. Upon GPCR activation, astrocytes can respond with transient variations in intracellular Ca2+. In addition, Ca2+-dependent an
Externí odkaz:
https://doaj.org/article/592e5c0c67f54706bd93f6726c129092
Autor:
Pojeong Park, John Georgiou, Thomas M. Sanderson, Kwang-Hee Ko, Heather Kang, Ji-il Kim, Clarrisa A. Bradley, Zuner A. Bortolotto, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conducta
Externí odkaz:
https://doaj.org/article/6bc2d2a14d284ff78483650a8ff577eb
Autor:
Thomas M. Sanderson, Liam T. Ralph, Mascia Amici, Ai Na Ng, Bong-Kiun Kaang, Min Zhuo, Sang Jeong Kim, John Georgiou, Graham L. Collingridge
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
In area CA1 of the hippocampus, long-term depression (LTD) can be induced by activating group I metabotropic glutamate receptors (mGluRs), with the selective agonist DHPG. There is evidence that mGluR-LTD can be expressed by either a decrease in the
Externí odkaz:
https://doaj.org/article/eacebaceb61d422c8659256a3053ba26
Autor:
Yeseul Lee, Zuner A. Bortolotto, Clarrisa A. Bradley, Thomas M. Sanderson, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
Glycogen synthase kinase 3 (GSK-3) is a Ser/Thr protein kinase that regulates many cellular processes, including synaptic plasticity. Previously, we reported that inhibition of GSK-3 prevents the induction of one of the major forms of synaptic plasti
Externí odkaz:
https://doaj.org/article/024d741368fa46b09ccbb6a0f17508d3
Autor:
Pojeong Park, Thomas M. Sanderson, Zuner A. Bortolotto, John Georgiou, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-5 (2019)
Abstract Theta-burst stimulation (TBS) induces short-term potentiation (STP) plus two types of transcriptionally-independent forms of long-term potentiation (LTP), termed LTP1 and LTP2. We have compared the susceptibility of these three types of syna
Externí odkaz:
https://doaj.org/article/b37950e94b1343fd95b24658078690e9
Publikováno v:
Frontiers in Neural Circuits, Vol 14 (2020)
Excitatory synapses in the mammalian cortex are highly diverse, both in terms of their structure and function. However, relationships between synaptic features indicate they are highly coordinated entities. Imaging techniques, that enable physiology
Externí odkaz:
https://doaj.org/article/2834a051351144fab2e686fbbb621c7d
Autor:
Pojeong Park, Heather Kang, Thomas M. Sanderson, Zuner A. Bortolotto, John Georgiou, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 11 (2019)
Classically, long-term potentiation (LTP) at hippocampal CA1 synapses is triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP)-AMPARs can also trigger synaptic plasticity at thes
Externí odkaz:
https://doaj.org/article/685fbc6002314c12ba217e1cfcd995bc
Autor:
Thomas M. Sanderson, Clarrisa A. Bradley, John Georgiou, Yun Hwa Hong, Ai Na Ng, Yeseul Lee, Hee-Dae Kim, Doyeon Kim, Mascia Amici, Gi Hoon Son, Min Zhuo, Kyungjin Kim, Bong-Kiun Kaang, Sang Jeong Kim, Graham L. Collingridge
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3631-3646.e3 (2018)
Summary: A major mechanism contributing to synaptic plasticity involves alterations in the number of AMPA receptors (AMPARs) expressed at synapses. Hippocampal CA1 synapses, where this process has been most extensively studied, are highly heterogeneo
Externí odkaz:
https://doaj.org/article/d290921b5af4434592a52c654baf45fc
Autor:
Pojeong Park, Heather Kang, Thomas M. Sanderson, Zuner A. Bortolotto, John Georgiou, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 10 (2018)
Long-term potentiation (LTP) at hippocampal CA1 synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors (AMPARs) can also trigger synaptic pl
Externí odkaz:
https://doaj.org/article/12475fd51ff74683a9d13db8676e4cd5
Publikováno v:
Cell Reports, Vol 28, Iss 5, Pp 1117-1118 (2019)
Nam et al. (2019) genetically modulate the expression of astrocytic μ-opioid receptors to reveal they are necessary for drug-induced conditioned place preference. These receptors trigger a mechanism involving metabotropic glutamate receptors to enha
Externí odkaz:
https://doaj.org/article/62a31e6af05d47c0b9c7086c5c5fbef4