Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Thomas M. Piers"'
Autor:
Katharina Cosker, Anna Mallach, Janhavi Limaye, Thomas M. Piers, James Staddon, Stephen J. Neame, John Hardy, Jennifer M. Pocock
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The R47H variant of the microglial membrane receptor TREM2 is linked to increased risk of late onset Alzheimer’s disease. Human induced pluripotent stem cell derived microglia (iPS-Mg) from patient iPSC lines expressing the AD-linked R47Hh
Externí odkaz:
https://doaj.org/article/21e1387021654817b07d89b643d58caa
Autor:
Xianyuan Xiang, Thomas M. Piers, Benedikt Wefers, Kaichuan Zhu, Anna Mallach, Bettina Brunner, Gernot Kleinberger, Wilbur Song, Marco Colonna, Jochen Herms, Wolfgang Wurst, Jennifer M. Pocock, Christian Haass
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-14 (2018)
Abstract Background The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2) significantly increases the risk for late onset Alzheimer’s disease. Mouse models accurately reproducing phenotypes observed in Alzheimer’ diseas
Externí odkaz:
https://doaj.org/article/84de6ae08e39439aa1de48d1143e1efb
Autor:
Anna Mallach, Johan Gobom, Charles Arber, Thomas M. Piers, John Hardy, Selina Wray, Henrik Zetterberg, Jennifer Pocock
Publikováno v:
Cells, Vol 10, Iss 11, p 2866 (2021)
Microglial exosomes are an emerging communication pathway, implicated in fulfilling homeostatic microglial functions and transmitting neurodegenerative signals. Gene variants of triggering receptor expressed on myeloid cells-2 (TREM2) are associated
Externí odkaz:
https://doaj.org/article/e5f7dfff72ee4e26a9361a11d732053f
Autor:
Thomas M. Piers, Emma East, Claudio Villegas-Llerena, Ioanna G. Sevastou, Mar Matarin, John Hardy, Jennifer M. Pocock
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Aberrant or chronic microglial activation is strongly implicated in neurodegeneration, where prolonged induction of classical inflammatory pathways may lead to a compromised blood-brain barrier (BBB) or vasculature, features of many neurodegenerative
Externí odkaz:
https://doaj.org/article/e9640ae60e9a49349b1b9f355430b1d8
Autor:
Alma S. Popescu, Claire A. Butler, David H. Allendorf, Thomas M. Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M. Pocock, Peter Thornton, Guy C. Brown
Publikováno v:
Glia. 71:974-990
Triggering receptor on myeloid cells 2 (TREM2) is an innate immune receptor, upregulated on the surface of microglia associated with amyloid plaques in Alzheimer's disease (AD). Individuals heterozygous for the R47H variant of TREM2 have greatly incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::949ea3333e1a15fbbee9497eb807be3f
https://doi.org/10.1002/glia.24318
https://doi.org/10.1002/glia.24318
SummaryNeuronal circuits evolve as a precisely patterned network. In this context, a growing neuron must locate the appropriate target area on a neurite of a neighbouring cell with which to connect. Controlled target selection involves dendritic filo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f81ee1a042d784e2711a46961aa529db
https://doi.org/10.1101/2023.02.17.528927
https://doi.org/10.1101/2023.02.17.528927
Publikováno v:
GliaREFERENCES.
One form of early life stress, prenatal exposure to glucocorticoids (GCs), confers a higher risk of psychiatric and neurodevelopmental disorders in later life. Increasingly, the importance of microglia in these disorders is recognized. Studies on GCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7dc57254c89d6971f4a09b9eb930c48
https://pubmed.ncbi.nlm.nih.gov/36571248
https://pubmed.ncbi.nlm.nih.gov/36571248
Autor:
Umran Yaman, Jennifer M. Pocock, Tamar Guetta-Baranes, Mina Ryten, John Hardy, Juan A. Botía, Valentina Escott-Price, Dimitra Sokolova, Eftychia Bellou, Naciye Magusali, Maryam Shoai, Thomas M. Piers, Andrew Graham, Regina H. Reynolds, Dervis A. Salih, Carlo Sala Frigerio, Keeley J. Brookes, Pantila Panichnantakul, Kevin Morgan, Sevinc Bayram
Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of Alzheimer’s disease, by its enrichment in transcriptional networks expressed by microglia. However, the function of OAS1 within microglia was not known. Using genot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5042787f0ef7de02303ec3f7b68c2cc6
https://orca.cardiff.ac.uk/id/eprint/148985/1/awab337.pdf
https://orca.cardiff.ac.uk/id/eprint/148985/1/awab337.pdf
Autor:
Jee-Hyun Yi, Chinedu Udeh-Momoh, Stafford L. Lightman, Eleanor Waite, Becky L. Conway-Campbell, Daniel J. Whitcomb, Thomas M. Piers, Garry Whitehead, Kwangwook Cho
Experience-dependent synaptic plasticity is important for learning and memory and regulated by the functions of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors. Glucocorticoids have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e2acd10599a559494c86d03ac38521
https://doi.org/10.21203/rs.3.rs-923210/v1
https://doi.org/10.21203/rs.3.rs-923210/v1
Autor:
Stephen J. Neame, Janhavi Limaye, John Hardy, Katharina Cosker, Jennifer M. Pocock, Thomas M. Piers, James M. Staddon, Anna Mallach
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
The R47H variant of the microglial membrane receptor TREM2 is linked to increased risk of late onset Alzheimer’s disease. Human induced pluripotent stem cell derived microglia (iPS-Mg) from patient iPSC lines expressing the AD-linked R47Hhet TREM2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1e6a1ef081eb7a32250ff1f0046e30
https://doi.org/10.1038/s41598-021-91207-1
https://doi.org/10.1038/s41598-021-91207-1