Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Thomas M. Mariano"'
Autor:
Christophe D, Guillon, Yi-Hua, Jan, Natalie, Foster, Mridula, Choudhuri, Jaya, Saxena, Thomas M, Mariano, Diane E, Heck, Jeffrey D, Laskin, Ned D, Heindel
Publikováno v:
Heterocycl Lett
The natural product 8-methoxypsoralen (methoxsalen or 8-MOP) in combination with long wavelength ultraviolet light (UVA, 320–400 nm), also referred to as PUVA therapy, is used for the treatment of cutaneous proliferative disorders including psorias
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11f5dc07a21a9b35589525645d6888cf
https://pubmed.ncbi.nlm.nih.gov/33575202
https://pubmed.ncbi.nlm.nih.gov/33575202
Autor:
Guohua Yi, Mauro Lapelosa, Rachel Bradley, Thomas M Mariano, Denise Elsasser Dietz, Scott Hughes, Terri Wrin, Chris Petropoulos, Emilio Gallicchio, Ronald M Levy, Eddy Arnold, Gail Ferstandig Arnold
Publikováno v:
PLoS ONE, Vol 8, Iss 9 (2013)
[This corrects the article on p. e72205 in vol. 8.].
Externí odkaz:
https://doaj.org/article/b6c95d785ec0409589b2888b78b7cdbe
Autor:
Guohua Yi, Mauro Lapelosa, Rachel Bradley, Thomas M Mariano, Denise Elsasser Dietz, Scott Hughes, Terri Wrin, Chris Petropoulos, Emilio Gallicchio, Ronald M Levy, Eddy Arnold, Gail Ferstandig Arnold
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72205 (2013)
The development of an effective AIDS vaccine has been a formidable task, but remains a critical necessity. The well conserved membrane-proximal external region (MPER) of the HIV-1 gp41 glycoprotein is one of the crucial targets for AIDS vaccine devel
Externí odkaz:
https://doaj.org/article/55c131554fbf455ea6d06d098223cba8
Identification of a Pyranocoumarin Photosensitizer that is a Potent Inhibitor of Keratinocyte Growth
Autor:
Jeffrey D. Laskin, Michele M. Jetter, Diane E. Heck, Christophe Guillon, Yi-Hua Jan, Ned D. Heindel, Thomas M. Mariano
Publikováno v:
Photochemistry and Photobiology. 94:577-582
Photosensitizers are used in the treatment of epidermal proliferation and differentiation disorders such as psoriasis and vitiligo. In these studies, a ring-expanded carbon homolog of the linear psoralen (furo[3,2-g]benzopyran-7-one) class of photose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b9c5961c8f7ab6133e1135af2e103b
https://doi.org/10.1111/php.12882
https://doi.org/10.1111/php.12882
Autor:
Keith Kardos, Christophe Guillon, Ned D. Heindel, Ivan Jabin, Michele M. Jetter, Thomas M. Mariano, Whittemore Marilyn S, Robert D. Rapp, Diane E. Heck, Yi Hua Jan, Jeffrey D. Laskin, Eric K. Akyea
Publikováno v:
Bioorg Chem
Bioorganic chemistry, 89
Bioorganic chemistry, 89
Seventy-one 7-oxycoumarins, 66 synthesized and 5 commercially sourced, were tested for their ability to inhibit growth in murine PAM212 keratinocytes. Forty-nine compounds from the library demonstrated light-induced lethality. None was toxic in the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de815f662141389c6adf1caf0dbac130
https://pubmed.ncbi.nlm.nih.gov/31170642
https://pubmed.ncbi.nlm.nih.gov/31170642
Autor:
Ned D. Heindel, Christine A. Martey, Debra L. Laskin, Whittemore Marilyn S, Jeffrey D. Laskin, Diane E. Heck, Thomas M. Mariano, Anna M. Vetrano
Publikováno v:
Biochemical Pharmacology. 70:1726-1734
Psoralens and ultraviolet light A (PUVA) are used in the treatment of a variety of epidermal proliferative and inflammatory disorders. These compounds are known to intercalate and photo crosslink DNA. Specific receptor proteins for psoralens have als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ae1b2e75576346ae0d03fdcd3a7dec
https://doi.org/10.1016/j.bcp.2005.10.001
https://doi.org/10.1016/j.bcp.2005.10.001
Autor:
Debra L. Laskin, Jeffrey D. Laskin, Anna M. Vetrano, Vladimir Mishin, Diane E. Heck, Thomas M. Mariano
Publikováno v:
Journal of Biological Chemistry. 280:35372-35381
Catalase is a highly conserved heme-containing antioxidant enzyme known for its ability to degrade hydrogen peroxide into water and oxygen. In low concentrations of hydrogen peroxide, the enzyme also exhibits peroxidase activity. We report that mamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565f38bb1afbf4e75b20461561f6f2c4
https://doi.org/10.1074/jbc.m503991200
https://doi.org/10.1074/jbc.m503991200
Publikováno v:
Journal of Biological Chemistry. 278:22432-22436
In keratinocytes, UVB light stimulates the production of reactive oxygen species (ROS). Lysates of these cells were found to possess a non-dialyzable, trypsin- and heat-sensitive material capable of generating ROS in response to UVB light. Using ion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92441b4aba0fab3fed1b2b0d28de673c
https://doi.org/10.1074/jbc.c300048200
https://doi.org/10.1074/jbc.c300048200
Publikováno v:
Biochemical Pharmacology. 64:1469-1481
Nitric oxide is an important mediator of excessive cell growth and inflammation associated with many epidermal proliferative disorders. It is a highly reactive oxidant generated in keratinocytes and macrophages via the inducible form of the enzyme ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684d54d07c980365dd62075e29f96263
https://doi.org/10.1016/s0006-2952(02)01419-3
https://doi.org/10.1016/s0006-2952(02)01419-3
Publikováno v:
Toxicology and Applied Pharmacology. 184:19-26
Bathing in chlorinated drinking water causes significant exposure to potentially toxic disinfection by-products (DBPs). In the present studies, we measured the permeation coefficients (K(p)) of three important classes of DBPs, trihalomethanes (THMs),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31cf1dc02ea94006845137f5ccbee616
https://doi.org/10.1006/taap.2002.9494
https://doi.org/10.1006/taap.2002.9494