Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Thomas M. Lancaster"'
Autor:
David G. Alleva, Eline A. Feitsma, Yester F. Janssen, Hendrikus H. Boersma, Thomas M. Lancaster, Thillainaygam Sathiyaseelan, Sylaja Murikipudi, Andrea R. Delpero, Melanie M. Scully, Ramya Ragupathy, Sravya Kotha, Jeffrey R. Haworth, Nishit J. Shah, Vidhya Rao, Shashikant Nagre, Shannon E. Ronca, Freedom M. Green, Stephen A. Shaw, Ari Aminetzah, Schelto Kruijff, Maarten Brom, Gooitzen M. van Dam, Todd C. Zion
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract AKS-452, a subunit vaccine comprising an Fc fusion of the ancestral wild-type (WT) SARS-CoV-2 virus spike protein receptor binding domain (SP/RBD), was evaluated without adjuvant in a single cohort, non-randomized, open-labelled phase II stu
Externí odkaz:
https://doaj.org/article/3e169ceb8cc4445682f02ab1847c3f9e
Autor:
David G. Alleva, Andrea R. Delpero, Thillainaygam Sathiyaseelan, Sylaja Murikipudi, Thomas M. Lancaster, Mark A. Atkinson, Clive H. Wasserfall, Liping Yu, Ramya Ragupathy, Rachel H. Bonami, Todd C. Zion
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe antigen-presenting cell function of insulin-reactive B cells promotes type 1 diabetes (T1D) in non-obese diabetic (NOD) mice by stimulating pathogenic T cells leading to destruction of insulin-producing β-cells of pancreatic islets.M
Externí odkaz:
https://doaj.org/article/b3f0b85106cd4df6a579f9f468414ba7
Autor:
Rikki Lissaman, Thomas M. Lancaster, Greg D. Parker, Kim S. Graham, Andrew D. Lawrence, Carl J. Hodgetts
Publikováno v:
Neuroimage: Reports, Vol 2, Iss 4, Pp 100126- (2022)
The parahippocampal cingulum bundle (PHCB) interconnects regions known to be vulnerable to early Alzheimer's disease (AD) pathology, including posteromedial cortex and medial temporal lobe. While AD-related pathology has been robustly associated with
Externí odkaz:
https://doaj.org/article/d8c56349dfa7432fa66252c22639646e
Autor:
Samuel C. Berry, Andrew D. Lawrence, Thomas M. Lancaster, Chiara Casella, John P. Aggleton, Mark Postans
Publikováno v:
NeuroImage, Vol 253, Iss , Pp 119096- (2022)
Invasive tract-tracing studies in rodents implicate a direct connection between the subiculum and bed nucleus of the stria terminalis (BNST) as a key component of neural pathways mediating hippocampal regulation of the Hypothalamic-Pituitary-Adrenal
Externí odkaz:
https://doaj.org/article/9dd44b0f88a24d0b863940acf0389985
Autor:
Stefanie C. Linden, Cameron J. Watson, Jacqueline Smith, Samuel J. R. A. Chawner, Thomas M. Lancaster, Ffion Evans, Nigel Williams, David Skuse, F. Lucy Raymond, Jeremy Hall, Michael J. Owen, David E. J. Linden, LeeAnne Green-Snyder, Wendy K. Chung, Anne M. Maillard, Sébastien Jacquemont, Marianne B. M. van den Bree
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Copy number variants are amongst the most highly penetrant risk factors for psychopathology and neurodevelopmental deficits, but little information about the detailed clinical phenotype associated with particular variants is available. We pr
Externí odkaz:
https://doaj.org/article/54da75375fc94e1e9cfee638da8b6e65
Autor:
Thomas M. Lancaster
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 368-373 (2019)
Abstract Introduction Recent exome sequencing studies have identified three novel risk variants associated with Alzheimer's disease (AD). However, the mechanisms by which these variants confer risk are largely unknown. Methods In the present study, t
Externí odkaz:
https://doaj.org/article/00fe0bb9527e49a1bb4d4814be8298eb
Autor:
Tamsin H. Sharp, Nancy S. McBride, Amy E. Howell, C. John Evans, Derek K. Jones, Gavin Perry, Stavros I. Dimitriadis, Thomas M. Lancaster, Luisa Zuccolo, Caroline Relton, Sarah M. Matthews, Thomas Breeze, Anthony S. David, Mark Drakesmith, David E. J. Linden, Tomas Paus, Esther Walton
Publikováno v:
Wellcome Open Research, Vol 5 (2020)
Neuroimaging offers a valuable insight into human brain development by allowing in vivo assessment of structure, connectivity and function. Multimodal neuroimaging data have been obtained as part of three sub-studies within the Avon Longitudinal Stud
Externí odkaz:
https://doaj.org/article/549896ca42b0487c9cc13bdda77fe848
Autor:
Stefanie C. Linden, Cameron J. Watson, Jacqueline Smith, Samuel J. R. A. Chawner, Thomas M. Lancaster, Ffion Evans, Nigel Williams, David Skuse, F. Lucy Raymond, Jeremy Hall, Michael J. Owen, David E. J. Linden, LeeAnne Green-Snyder, Wendy K. Chung, Anne M. Maillard, Sébastien Jacquemont, Marianne B. M. van den Bree
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/70c8d703a2c54c389267bed84f61ee90
Autor:
Viola Oertel-Knöchel, Thomas M. Lancaster, Christian Knöchel, Michael Stäblein, Helena Storchak, Britta Reinke, Alina Jurcoane, Jonathan Kniep, David Prvulovic, Kiran Mantripragada, Katherine E. Tansey, Michael C. O’Donovan, Michael J. Owen, David E.J. Linden
Publikováno v:
NeuroImage: Clinical, Vol 7, Iss C, Pp 764-770 (2015)
Polygenic risk scores, based on risk variants identified in genome-wide-association-studies (GWAS), explain a considerable portion of the heritability for schizophrenia (SZ) and bipolar disorder (BD). However, little is known about the combined effec
Externí odkaz:
https://doaj.org/article/8ce0e7377d7141ee8ad9fc0abe229e8c
Autor:
Stavros I. Dimitriadis, Krish D. Singh, Michael Conlon O'Donovan, Derek K. Jones, David Edmund Johannes Linden, Thomas M. Lancaster, George Davey Smith, Michael John Owen, Jeremy Hall, Stanley Zammit, Katherine E. Tansey, Gavin Perry
Publikováno v:
Biol Psychiatry Cogn Neurosci Neuroimaging
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(12), 1176-1184. Elsevier
Dimitriadis, S I, Lancaster, T, Perry, G, Tansey, K, Jones, D K, Singh, K D, Zammit, S, Davey Smith, G, Hall, J, O'Donovan, M C, Owen, M J & Linden, D E 2021, ' Global Brain Flexibility During Working Memory is reduced in a High Genetic Risk Group for Schizophrenia ', Biological Psychiatry, vol. 6, no. 12, pp. 1176-1184 . https://doi.org/10.1016/j.bpsc.2021.01.007
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(12), 1176-1184. Elsevier
Dimitriadis, S I, Lancaster, T, Perry, G, Tansey, K, Jones, D K, Singh, K D, Zammit, S, Davey Smith, G, Hall, J, O'Donovan, M C, Owen, M J & Linden, D E 2021, ' Global Brain Flexibility During Working Memory is reduced in a High Genetic Risk Group for Schizophrenia ', Biological Psychiatry, vol. 6, no. 12, pp. 1176-1184 . https://doi.org/10.1016/j.bpsc.2021.01.007
BACKGROUND: Altered functional brain connectivity has been proposed as an intermediate phenotype between genetic risk loci and clinical expression of schizophrenia. Genetic high-risk groups of healthy subjects are particularly suited for the investig