Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Thomas M. Koenig"'
Autor:
Neil J. Kallman, Bradley M. Campbell, David Mitchell, Declan Hurley, Jim Cashman, Thomas M. Koenig, Michael R. Heller, Richard D. Miller, Christopher S. Polster, Olivia Gowran, Scott A. May, Kenneth Desmond, Paul E. Sheehan, Robert Moylan, Paul Desmond, Martin D. Johnson, David P. Myers, Jennifer McClary Groh, Joseph L. Phillips, William D. Diseroad, John R. Howell, Timothy D. White, Christopher L. Burcham, Myers Steven Scott, Kevin P. Cole, Richard D. Spencer
Publikováno v:
Science. 356:1144-1150
Advances in drug potency and tailored therapeutics are promoting pharmaceutical manufacturing to transition from a traditional batch paradigm to more flexible continuous processing. Here we report the development of a multistep continuous-flow CGMP (
Autor:
Tony Y. Zhang, Hannah Yu, John R. Rizzo, Jeffrey A. Ward, Thomas M. Koenig, Rachel N. Richey, David Mitchell, Marvin M. Hansen, Neil J. Kallman, Ryan J. Linder
Publikováno v:
Organic Process Research & Development. 21:208-217
A practical pilot plant convergent synthesis of MR antagonist LY2623091 was established. For synthesis convergence, a vinyl bromide geometric isomer and chiral alaninol derivative were required building blocks. Key to the synthesis route development
Autor:
Jonas Y. Buser, David Mitchell, Thomas M. Koenig, LuAnne M. McNulty, Neil J. Kallman, Adam D. McFarland, Kevin P. Cole
Publikováno v:
Synthesis. 48:3537-3543
A single-step method and a two-step method for the synthesis of aminopyrazoles from isoxazoles are presented and compared. Based on in situ NMR monitoring, both processes proceed through a ketonitrile. In the single-step process, hydrazine serves to
Autor:
Thomas M. Koenig, Hossam Moursy, Norma Scully, Utpal K. Singh, Neil J. Kallman, Jonas Y. Buser, Jeremy M. Merritt, Alison N. Campbell, Jared W. Fennell, Mark A. Pietz
Publikováno v:
Organic Process Research & Development. 18:246-256
A mechanistic approach was undertaken to understand the oxygen sensitivity of a Pd-catalyzed amination reaction used in the synthesis of an active pharmaceutical ingredient. FlowNMR and dissolved oxygen probes were used as process analytical technolo
Publikováno v:
Organic Process Research & Development. 13:268-275
An efficient, scalable synthesis of the multipotent eicosanoid pathway modulator 2-[3-[3[[5-ethyl-4′-fluoro-2-hydroxyl[1,1′-biphenyl]-4-yl]oxy]-propoxy]2-propoxylphenoxy]benzoic acid (1) is described. The process consists of nine chemical steps w
Autor:
Thomas M. Koenig, James E. Audia, Mcdaniel Stacey L, Lynne A. Hay, Nissen Jeffrey S, David Mitchell
Publikováno v:
Tetrahedron: Asymmetry. 16:3814-3819
Two efficient production processes of enantioenriched 1-amino-3-methyl-1,3,4,5-tetrahydro-benzo[d]azepin-2-one 1 were achieved using the readily available starting materials. A key step in the methodologies is a classical resolution or a dynamic reso
Publikováno v:
Organic Process Research & Development. 4:513-519
Fluoxetine HCl was prepared by seven different synthetic routes, all previously reported. The major impurities in each route were identified by GC/MS, HPLC/MS, and gradient HPLC analysis. Impurities were classified as being derived from impurities in
Publikováno v:
The Journal of Organic Chemistry. 63:5050-5058
A general regio- and stereoselective synthesis of 3,3-diarylacrylamides is reported. Palladium-catalyzed coupling reactions of propiolamides with aryl halides provide arylpropiolamides. A subsequent hydroarylation reaction of these arylpropiolamides
Publikováno v:
The Physician and Sportsmedicine. 23:22-81
Autor:
Thomas M. Koenig, David Mitchell
Publikováno v:
Synthetic Communications. 25:1231-1238
A facile, high yield synthesis of R—or S—fluoxetine and norfluoxetine is described. This synthetic route utilizes readily available starting materials.